Allis Chien, Ph.D. Allis Chien. Ph.D., is director of the Vincent Coates Foundation Mass Spectrometry Laboratory, Stanford University’s mass spectrometry shared core resource facility (http://mass-spec.stanford.edu). The laboratory
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Everyone understands the maxim “garbage in, garbage out.” For most analytical methods, sample preparation is a given, an inextricable workflow component. The more careful the sample preparation, the greater the chance that the instrument will return a result that, if not exactly the desired one, is at least true.
In this month’s edition of INSIGHTS our panel of four experts discusses the types of MS analyses and experiments they run and the top factors they consider when buying MS instrumentation. We also explore the trend of the shrinking mass spectrometer in a Q & A sidebar with 1st Detect president and CTO Dave Rafferty.
MS originated as a stand-alone technique for volatile compounds. Next came the ability to volatilize high molecular weight materials through heating. The emergence of electron-impact ionization MS was a natural, as GC analysis requires volatilization. Find out what the future of MS holds.
Because modern mass spectrometers are based on solid-state electronics, they do not suffer from the mechanical and electronic problems of yesterday’s instruments. According to one expert, the top service-related issue today is an unintended consequence of instrument sensitivity and stability.
Sample preparation reduces sample complexity and renders samples into a format amenable to downstream analysis. Sample prep is most necessary for complex, multicomponent samples containing substances that interfere either with the MS (e.g., through ion suppression) or, in GC/LC-MS, the chromatography.
Q&A with Dave Rafferty, President and CTO at 1st Detect (Houston, TX)
Pharmaceutical and biotechnology companies have become leading MS customers. Because they work with human and test animal biological fluids and low-dose drugs, sample preparation takes center stage. Many of these workflows are automated for both sample and standards preparation.
One trend evident in science generally, and for laboratories in particular, is the desire to do things faster, more reliably and economically, at a higher level of hardware and method robustness, and all with a less-specialized workforce. This is especially true of mass spectrometry, where users no longer need a Ph.D. to operate MS systems.
Webinar: Overcoming Key Technological Challenges in Mass Spectrometry (MS)
Event Date: March 7 2013
Our panel of technical experts will provide details and data showing how mass spectrometry can be effectively used for diverse applications such as, compound analysis, protein characterization, biomarker discovery, and metabolite profiling.
Stephen Barnes, Ph.D., Professor of Pharmacology & Toxicology and Director f the Targeted Metabolomics and Proteomics Laboratory at the University of Alabama at Birmingham (UAB), talks about the changes taking place in the field of mass spectrometry (MS) as it migrates from the research lab to a clinical environment, for analysis of small molecules as well as large molecules like proteins and lipids. He also discusses some of the challenges facing MS users, particularly with data analysis and storage, when working with large amounts of MS data.
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Mass spectrometry (MS) involves the ionization of chemical samples to generate charged molecules or molecular fragments and measuring their mass-tocharge ratio.
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Mass spectrometry (MS) is the art of measuring atoms and molecules to determine their molecular weight. MS involves the ionization of chemical samples to generate charged molecules or molecular fragments and measuring their mass-to-charge ratio.
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TSQ 8000
- Now includes negative and positive ion chemical ionization (CI) capabilities
- Makes it easy for users to address further the chemical diversity they face in their most challenging analyses
- New direct insertion and direct exposure probe options further enhance the user’s ability to analyze samples
Thermo Fisher Scientific
www.thermoscientific.com
PHOTONIS MALDI TOF Detector
- Improves the detection efficiency of very high mass ions with significantly less complexity when compared to other high-mass MALDI-TOF detection solutions
- Features a large 250 mm2 collection area
- Provides high sensitivity detection for masses in excess of 100 kDa
PHOTONIS
www.photonis.com
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Webinar: Overcoming Key Technological Challenges in Mass Spectrometry (MS)
Event Date: March 7 2013
Our panel of technical experts will provide details and data showing how mass spectrometry can be effectively used for diverse applications such as, compound analysis, protein characterization, biomarker discovery, and metabolite profiling.
Webinar: The Latest In Sample Prep Techniques for Mass Spectrometry
Event Date: August 9 2012
In this free, educational webinar brought to you by Lab Manager Magazine a panel of technical experts representing leading vendors will discuss some of the trends and improvements in dealing with sample preparation for MS.
Webinar: The Utility of Mass Spectrometry for Food Safety Testing
Event Date: April 5 2012
In this webinar our panel of experts will provide input and case studies on how mass spectrometry can be effectively used for food testing and safety.
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Detection of carbendazim residue at concentrations below 10 PPB is possible without sample preparation or pre-concentration
Thermo Fisher Scientific Inc., the world leader in serving science, is proud to announce a selective and sensitive method for direct analysis of trace levels of fluoroacetate (FA, compound 1080) in environmental water samples.
Vitamin D status has been associated with a variety of disease states including cancer, cardiovascular disease, diabetes, multiple sclerosis, osteoporosis, rheumatoid arthritis, and chronic pain.
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| EST Analytical | GBC Scientific | Hitachi | JEOL |
| Kratos | LECO | PerkinElmer | Shimadzu |
| Syagen | Thermo Fisher Scientific | Varian | Waters |
| Zoex |
GC/MS Manufacturers
| Agilent | Bruker | LECO | PerkinElmer |
| Shimadzu | Thermo Fisher Scientific |
MS-TOF System Manufacturers
| AB Sciex | ALMSCO | DANI Instruments | LECO |
| Waters | Thermo Fisher Scientific |
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Problem: Accurate, high resolution mass spectrometry has grown ever more important in qualitative and quantitative analyses. Extreme systems such as Fourier Transform instruments (FTICR; FTMS) and magnetic sector instruments have addressed a substant
Problem: Mass spectrometry (MS) has become an indispensible technology for the analysis of compounds of biological interest, is widely available and offers rapid and accurate detection with broad applicability.
Design for atmospheric pressure ionization sources came of age in the late 1980s to provide a powerful analytical tool. The motivating force behind such invention has always been the need to answer questions better and faster with tools that
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Ocean Optics, inventors of the world’s first miniature spectrometer, introduces the latest additions to its portfolio of miniature photonics products. Our small-footprint UV to NIR spectrometers are easily customized for thousands of absorbance
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