September 2016 Technology News
The latest equipment, instruments, and system introductions to the laboratory market.
Analytical
Triple Quadruple ICP-MS System
8900
- The controlled-reaction chemistry of this inductively coupled plasma/mass spectrometry system delivers the lowest detection limits for previously difficult elements, such as sulfur, silicon, and phosphorus
- Includes a fast detector that sets a new benchmark for single nanoparticle applications
- Features ICP-MS MassHunter software
Agilent www.agilent.com
Self-Cleaning Ion Source
JetClean
- The first commercially available ion source that cleans itself
- Designed to keep Agilent quadrupole gas chromatography/mass spectrometry systems free of matrix deposits that would otherwise build up over time and degrade instrument performance
- Using a carefully controlled hydrogen flow, JetClean technology greatly reduces—or even eliminates—the need for source cleaning on Agilent single and triple quadrupole GC-MS systems
Agilent www.agilent.com
Spectrophotometers
Novaspec III+ and Novaspec Pro
- Compact, lightweight, and ergonomically designed • Include a large display that is easy to read and a simple user interface for rapid set up and analysis
- Novaspec III+ is an entry level visible spectrophotometer for labs performing basic spectroscopy measurements
- Novaspec Pro includes the same abilities as the III+, but adds multi-wavelength measurements and life science methods
Biochrom www.biochromspectros.com
Ultra-High Throughput Mass Spectrometer
rapifleX™ MALDI PharmaPulse™
- Can dramatically lower the cost of ultra-high throughput screening (uHTS) with further improved results
- Offers the speed, specificity, and robustness of mass spectrometry for large primary screens
- Compared to existing LC/SPE-MS HTS solutions, the system is 100-1000x faster and uses about 100x less solvent, without the need for LC columns and other LC consumables
Bruker www.bruker.com
Mass Spectrometer
timsTOF™
- Combines very high ion mobility resolution greater than 200, using Bruker’s proprietary Trapped Ion Mobility Spectrometry (TIMS), with Bruker’s ultra-high performance ESI-QTOF mass spectrometry
- A flexible, research-grade instrument for optimal separation and analysis of unresolved compounds and conformations
- Allows separation of isomeric compounds, accurate determination of collisional cross sections and gas-phase protein structure and aggregation studies
Bruker www.bruker.com
Sample Pretreatment Module for LC-MS
CLAM-2000
- Automatically performs all of the processes necessary for analyzing blood and other biological samples, from scanning in information from the blood collection tubes to sample pretreatment and LC-MS analysis
- First truly integrated sample preparation system for LC-MS that allows users to process samples in an instrument that is directly attached to the LC-MS system
- Helps to facilitate a safe working environment
Shimadzu www.ssi.shimadzu.com
MS-MS Hybrid Quadropole- Orbitrap Mass Spectrometer
Q Exactive BioPharma
- Enables three powerful workflows (denatured and native MS intact analysis, subunit and top/ middle-down analysis, and peptide mapping) for the complete characterization of biotherapeutics
- Encompasses all of Thermo Scientific’s leading technologies into one system
- Features a new High Mass Range (HMR) mode
Thermo Fisher Scientific www.thermofisher.com
Basic Lab
Discrete Analyzer
Smartchem 600
- Can perform up to 600 tests/hour
- Utilizes washable cuvettes with an integrated wash and control station, which guarantee a lower running cost and reduced risk of contamination
- Offers automated system quality control in addition to automated analysis
- Provides reduced hazardous waste management cost, reduced volume of waste, and low energy and water consumption
AMS Alliance www.amsalliance.com
Vortex Mixer
Stuart SA6
- Robust, with die cast construction
- Features a sophisticated inbuilt counterbalance system as well as suction cup feet to prevent any walking issues, which are often associated with budget vortex mixers
- Mixing speed ranges from 2500 to 4500 rpm, making the mixer suitable for a range of applications
Bibby Scientific www.bibby-scientific.com
Canopy Hoods
- Designed to collect and exhaust corrosive vapors, heat, steam, and odors
- Available in 36”, 48”, 72,” and 96” widths, in wall or island models
- Also available in either molded, chemical-resistant, flame retardant, one-piece composite resin, or fabricated of welded type 304 stainless steel
- Wall canopy hoods include a wall mounting kit
HEMCO www.HEMCOcorp.com/canopy.html
8- and 12-Channel Manual Pipettes
EVOLVE
- Pipette range now includes 8- and 12-channel versions
- Unlike traditional pipettes which utilize a single rotating plunger to set volumes, the EVOLVE features three adjustable dials for setting each individual volume digit
- Cover a volume range of 1 – 200 μl
- Able to enhance productivity and comfort even during prolonged pipetting sessions
INTEGRA www.integra-biosciences.com
Heating Stage
HS1500
- Can control sample temperatures up to 1500°C whilst maintaining a clear optical path for observing any changes in its characteristics
- Incorporates a large window that can be rotated to move a clear area into the optical path
- Features a ceramic heating cup which when used in conjunction with the ceramic cover creates a micro oven around the sample and heats at a rate of up to 200°C/min
Linkam www.linkam.co.uk
Tube Selector
- Offers the convenience of single-handed operation and the possibility to manually pick individual tubes from any tube storage rack without the necessity of lifting them
- Enables 'hands-free' manual picking and placing for labs looking to reduce contamination
- Easy-wipe-clean surface further reduces the chances of sample contamination
- Available as a low cost stand-alone product or as part of a starter pack
Micronic www.micronic.com/product/tube-selector
Peristaltic Pumps
Perimax 12 and Perimax 16
- Differ only in the number of rollers (12/16) in the pump head and the continuously adjustable flow rates they can achieve (0.0017 mL/min to 20 mL/min against 0.0034 mL/min to 40 mL/min)
- 16-roller pump produces no measurable pulsation
- Easy to use—the tube is guided around the pump head and its two ends are fixed to a special mechanism
Spetec www.spetec.de
Tempered Glass Modular Cleanroom
BioSafe®
- This free-standing, hardwall room is made of transparent glass panels attached to a stainless steel frame • Meets cleanliness ratings down to ISO 5
- Is non-sloughing, non-outgassing, and chemical-resistant, making it ideal for aseptic processes and frequent decontamination
- Ceiling grid supports electrical modules including LED or fluorescent lights, and HEPA or ULPA fan/filter units
Terra Universal www.TerraUniversal.com
Cell Culture
Research Tools for PD-1 Checkpoint Inhibitors
- New cell lines and controls for programmed cell death protein 1 (PD-1) research, and to test inhibitors of the PD-1 / PD-L1 pathway, are now available
- A PD-1 / NFAT Reporter - Jurkat cell line is for applications including screening for activators or inhibitors of PD-1 signaling in a cellular context
- The TCR activator / PD-L1 - CHO recombinant cell line is purpose-designed for screening for activators or inhibitors of PD-1 signaling, and more
AMSBIO www.amsbio.com/immunotherapy.aspx
Benchtop Scale Fermentation Systems
proSET
- Designed to provide an optimized cell cultivation solution for applications including growth of sensitive and fragile mammalian and insect cells
- Incorporate a large, color touchscreen panel with an intuitive software interface for ease of use
- Heating system allows operators to use any fermentation vessel type up to 20 liters, enabling a wide range of applications to be undertaken
Cleaver Scientific www.cleaverscientific.com
Cell Culture Vessel
CELLdisc
- Offers large growth surfaces on a small footprint and facilitates the scale-up of mass cell cultures
- Compact, robust, and cylindrical design means CELLdisc is just as suited to smaller test series as it is for automation and the quantifiable scale-up of mass cell cultures in sizes of between 1,000 and 10,000 square centimetres
- Ergonomic design simplifies the cultivation of mammalian cells
Greiner Bio-One www.greinerbioone.com
Cell Culture Media Filter
Virosart® Media
- Offers a fast and cost-effective solution for manufacturers to reduce the risk of virus contamination resulting from raw materials, such as chemically defined media, during fermentation
- This single-use filter provides a high level of safety for customers’ upstream processes as it is qualified for > 4 log10 reduction of small, non-enveloped viruses (e.g., MVM) and as a mycoplasma and leptospira retentive filter
Sartorius Stedim Biotech www.sartorius.com/virosart-media
96-Well Cell Culture Plate
Nunc Edge
- Designed to virtually eliminate the edge effect during lengthy incubation
- Even after long incubation periods of up to four days, the overall plate evaporation rate is reduced to less than 2 percent
- Allows all samples per plate to be analyzed, increasing assay performance with potentially less cost and related product waste
- Eliminates well-to-well variability
Thermo Fisher Scientific thermofisher.com/edgeplate
Chemicals, Kits, and Reagents
CRISPR gRNA Lentivector Cloning Kits
- Provide scientists with a targeted and precise genomic gene editing methodology
- Include the standalone premade Cas9 expression lentivirus, and the gRNA lentivector cloning kits from which users can construct their desired target gRNA lentivectors
- Enable rapid, precisely directional cloning of user’s DNA duplex encoded gRNA structure at efficiencies of greater than 95%
AMSBIO www.amsbio.com/lentivirus.aspx
Residual DNA Quantification Kits
ddPCR™ CHO & ddPCR™ E. coli
- Simplify the quantification of host-cell DNA (HCD) in process development, quality control, and biomanufacturing processes
- Allow for direct quantification of host-cell DNA impurities in biopharmaceuticals purified from bacteria (E. coli) or mammalian cells (Chinese hamster ovary) without the need for upfront nucleic acid purification steps
- Designed for use with Bio-Rad’s Droplet Digital™ PCR systems
Bio-Rad www.bio-rad.com/RDQKits
cDNA Synthesis Kit
RTScript™
- Allows users to produce robust cDNA yields in as little as 30 minutes
- Is a modified version of M-MLV Reverse Transcriptase with RNase H activity deactivated and increased thermal stability
- Sensitive, specific, and capable of synthesizing highly structured and long cDNA fragments
- Optimized to offer high reproducibility and efficiency for a broad range of primers and templates
Empirical Bioscience empiricalbioscience.com
Tris SDS PAGE Running Buffer
Fisher BioReagents FastRun
- Designed for use at higher voltages than traditional buffers, providing gradient-like electrophoretic separations of protein samples in nearly one-third less time
- Provides comparable or better resolution and an increased molecular weight separation range of proteins when compared to traditional Tris-Glycine-SDS buffer
- Reduces the number of Tris-Glycine polyacrylamide gel compositions required to resolve a protein, saving researchers time and money
Thermo Fisher Scientific www.fishersci.com/fastrunsdsbuffer
Informatics
Automated Metabolite Identification Platform
MetaSense
- Combines comprehensive metabolic transformation prediction with efficient analysis of LC-MS analytical measurements to identify, visualize, and report chemical biotransformations
- Will yield faster, easier, and more accurate detection and identification of predicted and unexpected metabolites
- Built on the ACD/Spectrus platform and offers knowledge management capabilities that allow the information gained in metabolite studies to be applied in other areas of R&D
ACD/Labs www.acdlabs.com
Chromatography System Software
ChromLab™ Software Version 4.0
- When used with Bio-Rad’s NGC chromatography system, the software version enables researchers to purify their proteins with ease
- Scouting wizard allows researchers to easily automate method optimization
- Enables control of multiple NGC systems from a single computer, further reducing the system’s footprint
- Allows simpler purification, quick onboarding of new users, and easier data analysis
Bio-Rad www.bio-rad.com/proteinpurificationsolutions
Web-Based Chemistry ELN
E-WorkBook for Chemistry Module
- Designed to support synthetic organic workflows in discovery chemistry
- Strengthens IDBS’ existing web capabilities, and follows on from a strategic technology partnership with ChemAxon announced in 2015
- Intuitive working environment covers all aspects of chemists’ workflow, including support for reaction planning, stoichiometry, molecule naming, semi-automated procedure write-ups, inventory lookup, and compound registration
IDBS www.idbs.com
LIS Solution
LimitLIS®
- Includes secure, sharp, and easily understood client/patient portals to modernize the laboratory’s web presence
- Features paperless e-requisitions, allowing clients to submit test orders online directly to the user’s lab, complete with patient information, billing details, and point of care tests
- Offers bidirectional and unidirectional integration with analyzers and seamless integration with EHR and billing providers
RURO limitlis.cloud
Dynamic Fielding Feature for Image Capture Software
- Now included in GeneSys image capture software
- Autocorrects for edge effects caused by all lens and lighting in image analyzers, providing a consistent image for scientists to accurately quantify DNA and proteins on their gels
- Saves scientists the time and effort of re-running gels to check their protein and DNA quantification results
Syngene www.syngene.com
PCR Set-Up Software
- Designed for Tecan’s D300e digital dispenser
- Offers new functionality and extends the D300e’s flexibility for genomics workflows
- Features a PCR Wizard that guides the user through qPCR set-up
- The D300e provides picoliter to microliter non-contact dispensing of liquids directly into assay plates and offers accurate and reproducible plate generation
Tecan www.tecan.com/d300e
LC-MS Data Analysis Software
Symphony Software
- Allows users to easily link tasks into a sequence to build the data processing pipelines that they need for their laboratories
- Provides time savings in data processing and automated analysis for out-of-hours working
- Minimizes user errors in repetitive tasks and is future proof, allowing use of the latest algorithms
- Helps maximize the return from LC-MS instrumentation
Waters www.waters.com
Lab Automation
Cartridge Extractor
SmartPrep Cartridge Extractor II
- Designed for method development and automation of previously developed manual methods
- Positive pressure consistently delivers the sample and solvents, yielding reproducible unattended results
- Cartridges of 1, 3, and 6-mL size from most manufacturers can be used in the system, easing the transition to automation
- Designed for special environmental applications
Horizon Technology www.horizontechinc.com
Robotic Gripper
The Gripster
- This patented electro servo gripper is used in a wide range of robotic systems
- Handles microwell plates without dropping, crushing, or otherwise mishandling them
- Detects the presence of an object, such as a microwell, based on force rather than a sensor; once force is detected, power is held constant, eliminating the risk of crushing
- Only a small amount of current is required
Let’s Go Robotics www.letsgorobotics.com
Nitrogen Blowdown Evaporator
Ultravap Levante
- Comes with an RS232 connection and a remote command set enabling it to connect to and be operated from most commercially available robotic liquid handling systems
- Features full-color touchscreen graphic displays, an integrated auto-ranging power supply, and built-in solvent fume venting
- Also offers multi-step ramped programming with full alphanumeric program naming
Porvair Sciences www.porvair-sciences.com
Automatic, High Throughput Viscometer
VROC® initium
- Equipped with automatic sample loading and sample cleaning
- Measures absolute viscosity as a function of shear rate across a wide temperature range, allowing unique viscosity fingerprinting of the samples
- Enables samples in 96-well plates as well as 40-vial racks to be tested automatically with intuitive software
- Also measures viscosity for sample volumes as little as 10 microliters
RheoSense www.rheosense.com
Life Science
Slide Hybridizer
RapidFISH
- Designed to simplify fluorescent in-situ hybridization (FISH) procedures for FFPE (formalin fixed paraffin embedded tissue) samples, cell suspensions, and other tissue preparation procedures
- Features a self-clamping slide tray design that maintains the required humidity
- Microscope slides in the RapidFISH do not require coverslips to be glued because the removable tray of the slide incubator traps moisture in the system
Boekel Scientific www.boekelsci.com
Single-Use Vessels
BioBLU®3f
- Developed specifically for microbial bioprocessing in working volumes of 1.25 to 3.75 L, extending the full range of operation for single-use fermentation from 60 mL to 3.75 L
- Address the demands of high cell density fermentation of bacteria, yeasts, and fungi
- Robust magnetic overhead drives featuring Rushton-type impellers support agitation rates up to 1200 rpm and provide high-performance mass transfer
Eppendorf www.eppendorf.com/BioBLUf
Transfection Unit
4D-Nucleofector™ LV
- Expands the proven 4D-Nucleofector™ system to closed, larger-scale transfection of up to 1x109 cells
- Transfection protocols can be established in smaller scale using the 4D-Nucleofector™ X unit and smoothly transferred to larger scale without the need for re-optimization
- With this new addition, small- and large-scale transfection applications are now united in one system based on the Nucleofector™ technology
Lonza www.lonza.com
FISH Probes
Cytocell Aquarius®
- Nine new probes now available: ETV6 Proximal Probe Green, ETV6 Distal Probe Red, MPO Probe Red, TP53 Probe Green, NUP214 Probe Red, DEK Probe Green, TAS2R1 (5p15.31) Probe Green, Chromosome 9 Satellite III Probe Aqua, and Chromosome 15 Alpha Satellite Probe Red
- Produce specific, high-intensity signals with excellent contrast and minimal background
- Optimized for use on common sample types
Oxford Gene Technology www.cytocell.com
Bioreactor System
ambr® 250 modular
- This benchtop mini bioreactor system is designed for parallel fermentation or cell culture
- Combines a unique single-use bioreactor vessel and expandable system design to offer bioprocess scientists access to advanced benchtop bioreactor technology for process development
- Consists of a workstation with 2, 4, 6, or 8 single-use bioreactors, with a working volume range of 100 to 250 mL
Sartorius www.sartorius.com
Supplies and Consumables
On-Line SPE Cartridges
ISOLUTE® ENV+
- Designed for use primarily in integrated SPE-HPLC-(MS-MS) systems
- Contain either EVOLUTE® EXPRESS ABN or ISOLUTE® ENV+ sorbents and consist of a stainless steel cartridge with standard HPLC compatible end fittings
- Allow sample preparation to be fully integrated into an automated analytical workflow
- Aimed primarily at the environmental market for extraction of trace organic analytes from water samples
Biotage www.biotage.com
Bottletop Dispensers
BRAND Dispensette® S
- Feature improved safety valves, faster priming, easier volume selection, and even lower operation forces
- All seals have been eliminated to have even less wearing parts to replace over time
- A large variety of bottle adapters and accessories adapt the Dispensette® S to virtually any unpressurized application
- Models are available for general purpose dispensing, organics and concentrated acids, and trace analysis
BrandTech Scientific www.brandtech.com
Super Precision Vessels for Dissolution Testers
SPV™
- Designed for Hanson’s Vision G2™ series of dissolution testers
- With its closer conformance to an ideal vessel shape, these vessels provide more consistent vessel-to-vessel dissolution test results in USP Apparatus 2
- Resolves issues relating to routine calibration of dissolution testing equipment
- Available in 1-liter vessel capacities, clear or amber, for the SR8-Plus, Vision G2 Classic 6, and Vision G2 Elite 8 dissolution testers
Hanson Research hansonresearch.com
Amber-Tinted Polypropylene Storage Tubes
- Now available in 0.75ml and 1.40ml volumes
- When used in conjunction with a secure screw cap or push cap, these tubes ensure the integrity of light sensitive biological samples even over long-term storage periods
- Available in non-coded and laser encrypted 2D coded formats
- Supplied in a 96-position sample tube storage rack that meets the ANSI / SLAS standard footprint
Micronic www.micronic.com
β-Glucuronidase Removal Tubes & 96-Well Plates
β-Gone
- Designed for the cleanup of hydrolyzed urine samples in less than one minute
- Offers a simple, rapid solution for β-glucuronidase removal that improves assay performance and column lifetime, and reduces mass spec maintenance
- Also offers a better alternative to the “dilute-and-shoot” method in which sensitivity and accuracy are compromised when the sample is diluted
Phenomenex www.phenomenex.com
Septa
Thermolite Plus
- Ultra-low bleed characteristic of these new septa minimizes the background signal, and the plasma coating prevents the septa from sticking in the injection port
- Precision molding ensures a consistent, accurate fit
- Select septa feature a CenterGuide design to minimize coring
- Usable up to 350°C and come preconditioned and ready to use
Restek www.restek.com/ThermolitePlus
Black and White ELISA Plates
- Provide medium binding surfaces for hydrophobic interactions and high binding surfaces for more hydrophilic interactions
- Inclusion of white and black ELISA plates in the Sarstedt product line provides greater flexibility for use with a variety of ELISA detection methods
- New white plates are especially recommended for performing luminescence measurements, and the black ELISA plates are recommended for performing fluorescence measurements
Sarstedt www.sarstedt.com