November 2016 Technology News

In this issue we highlight companies that will be exhibiting at the American Society for Cell Biology’s (ascb) Annual Meeting (cell biology 2016). This event, which focuses on the latest advances in cell biology such as CRISPR, will run Dec. 3-7 in San Francisco, CA. Please note that the specific technologies featured here may not necessarily be at the show, but their manufacturers and distributors will be on hand to answer any questions you may have.

Analytical

Triple Quadrupole GC/MS Instruments

7000D and 7010B

Include enhancements that not only improve analytical performance but make them easier to use than any previous triple quad GC/MS system
Agilent’s single quad GC/MS installed customer base, who want to run samples on their triple quad, can open existing single quad GC/MS methods with a single mouse click using Agilent MassHunter software
7010B includes Agilent’s exclusive high-efficiency ion source

Agilent www.agilent.com

EBSD Detectors for Scanning Electron Microscopes

e-FlashFS & e-FlashHD
Booth 501

Designed for electron backscatter diffraction (EBSD) analysis on scanning electron microscopes
Optimally cover all EBSD applications from everyday characterization of minerals and alloys to advanced analysis of nano and functional materials
e-FlashFS provides an increase in sensitivity by a factor of three compared to its predecessor, the e-Flash1000
The e-FlashHD detector features a CCD camera resolution of 1,600 x 1,200 pixels and state-of-the-art camera optics

Bruker www.bruker.com

Spectrophotometer Systems

Flame-CHEM

These systems combine a high performance, compact Flame UV-Vis (200-850 nm) or Vis-NIR (350-1000 nm) spectrometer, with an all-in-one direct-attach light source and cuvette holder, into a single affordable package
Suited for regular absorbance and transmission measurements in teaching labs and research facilities
Can easily be customized, providing flexibility as measurement needs change

Ocean Optics www.OceanOptics.com

Thermal Field Flow Fractionation System

TF2000

Provides a highly efficient method of separating and characterising complex polymer samples from approximately 10 kDa up to 100 MDa and more in organic and aqueous solvents
Uses a temperature gradient as the driving force for its separation of polymers and particles
Does not require sample treatment as samples can be injected without pre-filtration

Postnova www.postnova.com/tf2000-overview.html

BioEthanol Analyzer

Based on the Prominence-i integrated HPLC platform
Provides an advanced tool for real-time monitoring of the fermentation process in bioethanol production
Remote monitoring of the BioEthanol Analyzer via the i-Series web interface or LabSolutions Direct provides instrument status and chromatogram information from anywhere using any smart device or PC • Built-in ECO mode reduces power consumption and mobile phase usage

Shimadzu www.ssi.shimadzu.com

Binary UHPLC System

Vanquish Flex
Booth 815

Adds a binary solvent delivery option in the 1000 bar (15,000 psi) performance range
Built for high-speed, fast gradient applications and the Vanquish platform’s inherent outstanding retention time reproducibility
Features a binary high-pressure gradient pump with 2 x 3 solvent channels and low gradient delay volume capable of delivering high flow rates of up to 8 mL/min

Thermo Fisher Scientific www.thermoscientific.com/vanquish

Benchtop Mass Spectrometer

Xevo® TQ-XS

Enabled by the newly designed StepWave™ XS ion guide
Features a unique combination of ion optics, detection and ionization technologies resulting in levels of sensitivity not previously seen
Refined design allows the system to quantify challenging compounds at trace levels—even if they are labile or show poor transmission efficiency

Waters www.waters.com/xevotqxs

Basic Lab

Reaction Inserts for Heating Blocks

Designed for Asynt’s DrySyn range of heating blocks
Enable scientists to now conduct precisely controlled heated/stirred experiments in three dram vials, 20ml scintillation vials, and 2ml HPLC sample vials
New multi position blocks, when combined with a DrySyn base unit, allow up to 27 experiments to be performed in parallel

Asynt www.asynt.com

UV Fiber Optic System

Opt-Diss 410

In-situ system is designed for dissolution testing
Measures directly in the vessel, eliminating problematic filters, tubing, and pumps used in conventional sampling
Patented ARCH probes designed specifically for dissolution eliminate bubbles and trapped particles that plague other fiber systems
New multicomponent analysis allows quantifying two components at once, without the need for separation

Distek www.distekinc.com

High-Speed 5MP Camera

IL5

Easily mounted on users’ microscopes, enabling them to record high-speed video of microscopic events
Feature four models to choose from and crisp, clean video from 2560 x 2080 @ 230fps to 800 x 600 @ 1650fps
All models record over 3200 fps at VGA resolution and more than 18,000 fps at smaller resolutions

Fastec Imaging www.fastecimaging.com

Pump for Liquid Chromatography

Intelligent Pump UI-12

Features ultimate low pulsation as well as an innovative suction and discharge system
Makes it possible to keep a constant flow rate even with trapped air bubbles and allows for reliable intake from containers placed below the pump
Includes a dual identical plunger assembly, with each plunger being completely controlled by software
Comes in two plunger type varieties: 3.2mm analytical or 9.5mm semi-prep

JM Science www.jmscience.com

Benchtop Nitrogen Gas Generator System

Solaris

Developed to offer a compact and convenient gas source for labs using ELSD (evaporative light scattering detector) instruments and compact mass spectrometers
Provides a consistent source of nitrogen gas for these applications, typically requiring lower flow rates and specific purity
Capable of delivering up to 10L/min and at purity levels of up to 99.5% (at lower flow rates)

Peak Scientific www.peakscientific.com/solaris

Microscope Stage

H112
Booth 615

Offers a travel range of over 300 x 300 mm
Suited for accurate and precise scanning of semiconductor wafers, photo masks, flat panel displays, and printed circuit boards
Fully compatible with a wide range of microscopes
Can easily accommodate wafers up to 12-inches (300mm) in diameter, or samples up to 25kg in weight, and works with many robot arm wafer loaders

Prior Scientific www.prior.com

Wireless Integrated Sensors

Pressure Scout

Consist of a pressure sensor integrated with a wireless node and internal battery
Support pressure monitoring and alarm reporting as part of the SignalFire remote sensing system
Provides a low-cost alternative to conduit-wired or other wireless pressure monitoring solutions
Suited for well tubing and casing pressure monitoring, tank level monitoring, and compressor station status monitoring

SignalFire Wireless Telemetry www.signal-fire.com

UV-Blue Light Converter Screens

Can quickly and simply change harmful UV into blue light
Offer a safe, affordable way of using the UV transilluminator in Syngene imaging systems to visualize DNA and protein gels labeled with many commercial fluorescent dyes
Come in two sizes (21cm x 26cm and 25cm x 30cm) and are made of scratch-resistant plastic

Syngene www.syngene.com/uv-blue-light-converter

Motorized Shoe Cleaner

Designed for labs, cleanrooms, and gowning rooms
Automatically brushes and vacuums shoes with the simple push of a lever
Inside the housing, five brushes placed at various angles are activated to clean all surfaces of the shoe
On-off lever is an easy-reach, waist-high handle, also serving to help workers balance during the cleaning cycles

Terra Universal www.TerraUniversal.com

Chemicals, Kits, and Reagants

Immunotherapy Research Products

Booth 1211

New range of TIGIT receptor products includes a Jurkat cell line, homogeneous assay kits, and recombinant proteins for immunotherapy research
The TIGIT homogeneous assay kits, include a CD112 kit to measure the inhibition of TIGIT binding to CD112 (PVRL2/Nectin-2) and a CD155 kit designed to measure the inhibition of TIGIT binding to CD155

AMSBIO www.amsbio.com/immunotherapy.aspx

Kit for Extraction of Genomic DNA from Plant Tissue

MagSi-DNA Vegetal
Booth 1211

Brings the convenience and cost effectiveness of magnetic bead technology to the world of plant genomics
Flexible protocols can be adjusted to optimize the researcher’s specific plant extraction protocol requirements
System is fully compatible with high-throughput robotic liquid handling systems, as well as smaller-scale plant genomics projects

AMSBIO www.amsbio.com/magnetic-beads.aspx

DNA Blood Kit

(IVD) Arcis

This kit is for preparation of DNA from blood using a novel three-minute, two-step system, designed for in vitro diagnostic use
Sold in a ready-to-use format, and enables users to stabilize and extract nucleic acid from fresh or frozen whole blood samples in just three minutes, without the need for prior sample preparation steps
Non-hazardous, and ships and stores at room temperature for ease of handling

Arcis Biotechnology www.arcisbio.com

Magnetic Purification System

AbPure™

Based on Protein A magnetic beads, which have a high affinity for IgG molecules and allow scientists to purify small quantities of antibody from complex mixtures
Contains novel buffer compositions that are compatible with every conceivable approach to conjugation, including Innova’s Lightning-Link®, Thunder-Link®, InnovaCoat® GOLD, and LATEX conjugation kits
Will save researchers time, improve antibody yields, and facilitate the production of conjugates

Innova Biosciences www.innovabiosciences.com

Residual Protein A Detection Kit

Ready BLI

Designed for Octet® systems
Gives users a fast and simple way to test for the presence and concentration of Protein A or MabSelectSure™ bioprocessing samples
Does not require the manual sample prep steps like heating, centrifuging, and washing typically needed with ELISA
Provides results in two hours when paired with the Octet HTX system

Pall ForteBio www.fortebio.com

Cas9 Nuclease

XactEdit™

This highly active, purified recombinant Streptococcus pyogenes Cas9 protein mediates site-specific double-stranded DNA cleavage when complexed with a guide RNA
Available as a kit or a standalone enzyme (1mg/mL or 10mg/mL)
Delivers consistent and robust performance
Especially suited for in vitro assays or for introduction into cells by electroporation or transfection

SGI-DNA sgidna.com/xactedit-cas9-nuclease.html

Informatics

Spectroscopy Software & Databases

KnowItAll® 2017
Booth 1109

Offers an additional 976,000 reference spectra in the KnowItAll Spectral Library including Bio-Rad’s Sadtler™ spectra as well as spectra from John Wiley & Sons, Inc.
Database collection now includes over 2.3 million spectra
Allows users to save time by automatically importing structures and properties directly from PubChem to enhance user-built databases

Bio-Rad www.knowitall.com/whatsnew

Microscopy Stage Software

LINK

Delivers a practical and intuitive system experience to users of temperature controlled microscopy stages
Allows users to control and monitor the different physical parameters for Linkam stages from one central interface
Can be programmed with up to 100 ramps, making it easy for even complex experiments to be run

Linkam www.linkam.co.uk

Instrument Utilization Dashboard

TetraScience Utilization

Provides a dynamic dashboard of instrument usage data and analytics
Shows trends in instrument use so labs can make data-driven decisions around which capital expenditures to invest in, where to adjust service contracts and preventive maintenance, when to redeploy or resell depreciating equipment, how to optimize instrument scheduling, and where to eliminate bottlenecks during high growth periods

TetraScience www.tetrascience.com

Software for Small Molecule Research

Compound Discoverer™ 2.0
Booth 815

Offers a full suite of powerful tools to address mass spectrometry-based small molecule differential analysis, identification, and pathway mapping
Provides simplified data processing and integrated compound identification
Also features streamlined data assembling from one or more experiments

Thermo Fisher Scientific www.thermofisher.com

Sample Tracking

Software Samples

Recent updates will allow for the improved importing of large legacy data files, the enhancement of the audit trail for individual samples, and improvements to the search facility for sample retrieval
Now has an improved function for the importing of large amounts of legacy data, which can then be searched for and retr ieved in the database, even if the samples do not have barcodes

Ziath ziath.com/index.php/products

Lab Automation

Automated Extraction System

InnuPure® C16 touch

Combines highly precise liquid handling with automated extraction, using magnetic-particle separation as a basis for isolating high-quality nucleic acids
Well-established walk-away principle ensures that the entire process—up to and including analysis—is fully automated once the initial manual loading step is complete
1 mL pipette tips with aerosol filters effectively prevent contamination of the dispensing unit and samples

Analytik Jena www.analytik-jena.com

Automated Reagent Injector

Asia

Designed for use with Asia flow chemistry systems, enabling fully automated experiments with multiple reagents
Driven by the Asia syringe pump module
Offers high performance, fully automated sample injection via two independent channels, allowing complex matrixed libraries to be synthesized
Gas blanketing provides the inert sampling conditions required for safe handling of air and moisture sensitive reagents

Syrris syrris.com

Automated Sample Purification System

KingFisher Presto
Booth 815

Designed to be part of an automated workflow using a liquid handler with a gripper or robot arm to purify samples with volumes from 50μL to 5mL
A small footprint allows for easy connection to several liquid handling instruments in either a side-by-side or on-deck configuration, allowing flexible selection of platform and use for a wide variety of applications

Thermo Fisher Scientific thermofisher.com/kingfisherpresto

Life Science

Silicon Photomultiplier

PET Insert
Booth 501

Designed for simultaneous positron emission tomography / magnetic resonance imaging) investigations in mice and rats
Compatible with MRI systems up to 15.2 Tesla
Allows simultaneous measurements for the perfect correlation of PET and MRI data in space and time, in order to examine tracer kinetics, therapeutic agent distribution, and animal physiology

Bruker www.bruker.com

Preclinical Imaging System

SkyScan™ 1276
Booth 501

Provides improved in vivo scanning of small laboratory animals and of in vitro biological samples in preclinical studies
Features continuously variable magnification, including a smallest pixel size of 2.8μm, and a shortest scanning cycle of 3.9 seconds
Gives researchers access to highest-quality images at higher throughput
The world’s first in vivo microCT system with rapid helical scanning

Bruker www.bruker.com

Single Cell RNA-Seq System

Developed for efficient, high throughput single cell transcriptomics
Compact, scalable system enables rapid, reproducible droplet encapsulation of individual cells, allowing up to 10,000 single cell libraries to be generated in one 15-minute run
Allows up to 500 μl samples of cells and oligo-barcoded beads to be encapsulated in extremely monodisperse droplets, each containing a single cell

Dolomite Bio www.dolomite-bio.com

Syringe Pump

Pump 33 DDS

Features two independent pumping channels controlled by an intuitive touchscreen interface
This multi-purpose syringe pump employs advanced syringe mechanisms that include a tight gripping, extremely secure syringe clamp that accommodates syringe sizes 0.5 μl to 60 ml
Offers enhanced flow performance with high accuracy and smooth flow from 1.02 pl/min to 106 ml/min

Harvard Apparatus www.harvardapparatus.com

CE-IVD Labeled FISH Probes

Cytocell Aquarius® ROS1 Plus Breakapart and RET Breakapart probes specifically and accurately detect rearrangements in the genome associated with the most common form of lung cancer— non-small cell lung cancer (NSCLC)
In OGT validation studies, the new Cytocell probes for NCSLC showed tight, bright signals allowing easy visualization and scoring of results • Available in two economical sizes and are premixed in hybridization buffer

Oxford Gene Technology www.ogt.com/NSCLC

Diagnostic Assays for Systemic Sclerosis

Multilisa® CENP-B and Scl-70

Multilisa® SSc program combines novel and proprietary markers with existing diagnostic standards to help understand the condition at a molecular level
Intended for the semi-quantitative determination of IgG antibodies specific for the CENP-B and Scl-70 proteins
Are the first Protagen CE marked diagnostic assays in an easy to use ELISA format

Protagen www.protagen.com

Crossflow Filter

Sartocon® Slice 50 ECO

Specially designed for water-based protein solutions with viscosities below 3 cp
The crossflow cassette can typically be used in biotech applications, such as filtration of IgG, blood factors and peptides, especially involving membrane screening and small-volume process development
Reduced flow channel geometry of the new filter lowers the recirculation pump requirements by as much as 50% versus a standard design

Sartorius www.sartorius.com/sartoflow-smart

Fully Integrated Upstream Platform

Designed to meet the requirements of today’s upstream bioprocessing
Combines a top-performing expression system with equipment and process control for the rapid development and scale-up of robust, high-titer commercial manufacturing processes
Biopharmaceutical manufacturers will be able to reach the clinic in 14 months by leveraging this new platform

Sartorius www.connect-upstream.com

High Density Cell Factory System

Nunc
Booth 815

Designed to provide efficient and economical large-scale production of cells by increasing productivity within the same manufacturing space
Incorporates additional layers compared with the standard Nunc Cell Factory systems, increasing surface area and yield up to 30 percent, depending on the type of cells cultured
Available in 3-, 13- or 52- layer options

Thermo Fisher Scientific thermofisher.com/cellfactory

Services

Human iPSC-Based Discovery Services

Support both preclinical neuroscience and chronic pain research
Offered through a partnership between Cellectricon AB and Censo Biotechnologies Ltd.
Collaboration provides the opportunity to meet industry’s demands for drug discovery models that are closer, and therefore more relevant, to humans

Cellectricon www.cellectricon.com

Mitochondrial Toxicity Testing

3D InSight™

New service is for the identification of mitochondrial liabilities during drug development and safety testing
Combines the organotypic liver functionality and 28-day in vitro lifespan of 3D InSight™ human liver microtissues with state-of-the-art analysis of mitochondrial respiration using the Agilent XFe96 analyzer
Capitalizes on the in vivo-like biology of 3D human liver microtissues

InSphero www.insphero.com

Supplies and Consumables

Organic Bottletop Dispensers

Dispensette® S Organic

Part of the latest generation of BRAND bottletop dispensers
Improvements include elimination of seals, lower operating forces, easier priming, and a new safety discharge system
Bottle adapters and accessories allow use with nearly any unpressurized system
Digital models are available for highly reproducible settings, analog models for rapid volume changes, or fixed volume models for standardized protocols

BrandTech Scientific www.brandtech.com

Plate Holder for Electronic Pipette

Enables 1536-well pipetting on INTEGRA’s VIAFLO 384 electronic handheld pipette
Provides screening labs with a unique alternative to fully automated robotic liquid handling systems
For optimal alignment of the pipetting head with the target 1536 well plate, the new plate holder is adjustable in the y-direction
Features easy to use slide function providing access to all four quadrants with a 384-channel pipetting head

INTEGRA www.integra-biosciences.com

Chiral Columns

Lux i-Cellulose-5

New Lux media is more robust than other chiral offerings on the market thanks to a manufactured chemical crosslinking between the polysaccharide and silica supports
Can be used with even the strongest organic solvents, and offer greater sample loading and method development flexibility
Dichlorophenylcarbamate selector of the new media combines well with Phenomenex’s other Lux chiral stationary phases

Phenomenex www.phenomenex.com

GC Inlet Liners

Zebron PLUS

Designed with a pre-installed Viton O-ring to eliminate installation steps
Easy-to-open packaging also prevents pitfalls that commonly occur during liner installation, including breakage, cuts, and potential contamination
Specially deactivated during manufacturing and tested for activity against established EPA 8081 and 8270, which are representative methods for typical compounds of concern

Phenomenex www.phenomenex.com

Microplates

sol-R™

Designed to amplify the productivity gains delivered by laser-scanning fluorescence cytometers by enabling users to deliver reliable decision making data faster
Validated for use with TTP Labtech’s acumen and mirrorball cytometers
Provide the convenience of an off-theshelf consumable and the benefits of custom design
Developed for use with microscope-based imaging devices, enabling users to transfer seamlessly between devices

TTP Labtech ttplabtech.com/cell-imaging/mirrorball