Sea UrchinThe red sea urchin, Mesocentrotus franciscanus, is one of the world's longest-lived organismsPhoto Courtesy of: MDI Biological Laboratory

 

Bar Harbor, ME—Sea urchins are remarkable organisms. They can quickly regrow damaged spines and feet. Some species also live to extraordinary old ages and—even more remarkably—do so with no signs of poor health, such as a decline in regenerative capacity or an increase in age-related mortality. These ocean Methuselahs even reproduce as if they were still youngsters.

MDI Biological Laboratory associate professor James A. Coffman, PhD, is studying the regenerative capacity of sea urchins in hopes that a deeper understanding of the process of regeneration—which governs the regeneration of aging tissues as well as lost or damaged body parts—will lead to a deeper understanding of the aging process in humans, with whom sea urchins share a close genetic relationship.

In a paper recently published in Aging Cell, a leading journal in the field of aging biology, with Andrea G. Bodnar, PhD, of the Bermuda Institute of Ocean Studies, the scientists shed new light on the aging process in sea urchins, raising the prospect that the physical decline that typically accompanies aging is not inevitable.

They studied regenerative capacity in three species of sea urchins with long, intermediate and short life expectancies: the red sea urchin, Mesocentrotus franciscanus, one of the world's longest-lived organisms with a life expectancy of more than 100 years; the purple sea urchin, Strongylocentrotus purpuratus, with a life expectancy of more than 50 years; and the variegated sea urchin, Lytechinus variegatus, with a life expectancy of only four years.

The scientists hypothesized that the regenerative capacity of the species with shorter life expectancies would decline as they aged. Much to their surprise, however, they found that regenerative capacity was not affected by age: as with the very long-lived sea urchin, the regenerative capacity of the species with a shorter life expectancy did not decline with age.

"We wanted to find out why the species with short and intermediate life expectancies aged and the long-lived species didn't," said Coffman. "But what we found is that aging is not inevitable: sea urchins don't appear to age, even when they are short-lived. Because these findings were unexpected in light of the prevailing theories about the evolution of aging, we may have to rethink theories on why aging occurs."

The MDI Biological Laboratory in Bar Harbor, ME, is an independent, nonprofit biomedical research institution focused on increasing healthy lifespan and harnessing the natural ability to repair and regenerate tissues damaged by injury or disease. The institution develops solutions to complex human and environmental health problems through research, education and ventures that transform discoveries into cures.

Coffman and other scientists working in the institution's Kathryn W. Davis Center for Regenerative Medicine study tissue repair, regeneration and aging in a diverse range of organisms that have robust mechanisms to repair and regenerate tissue.

The prevailing theory of the evolution of aging holds that aging is a side effect of genes that promote growth and development of organisms that have a low likelihood of continued survival in the wild once they have reproduced. Many organisms with a low expectation of survival in the wild experience rapid decline once they have reached reproductive maturity.

But Bodnar and Coffman's findings contradict that theory. They found that although the variegated sea urchin, L. variegatus, has a much lower life expectancy in the wild than the other two species they studied, it displayed no evidence of a decline in regenerative capacity with age, which suggests that senescence may not be tied to a short life expectancy in the wild.

The scientists are planning future studies to identify why short-lived sea urchins experience negligible senescence, and, in particular, the role of the immune system in maintaining youthful function into old age.

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The MDI Biological Laboratory, located in Bar Harbor, ME, is an independent, non-profit biomedical research institution focused on increasing healthy lifespan and increasing our natural ability to repair and regenerate tissues damaged by injury or disease. The institution develops solutions to complex human health problems through research, education and ventures that transform discoveries into cures. For more information, please visit https://mdibl.org/