AMES, Iowa – Farmers often go to great lengths to keep viruses and aphids out of their fields, but Iowa State University scientists are imagining a future in which these harmful agents could be engineered to help crops.
It’s a wild and highly speculative idea, the researchers admit. But the research will unearth valuable clues about how viruses, insects, and plants interact and could lead to new interventions to safeguard the food supply.
The research aims to engineer viruses that activate desirable traits in mature corn plants, using insects to transmit the viruses. The team hopes to develop a means of rapidly responding to crop threats such as drought and disease, conferring protection within a single growing season.
“Viruses are well-suited for this purpose because they are natural, mobile gene packages that express proteins in plants, but they’re not inherited in the plant seed,” Miller said.
That provides a built-in biosafety mechanism to prevent long-term presence of the engineered genes in the plants when those genes are no longer needed, he said.
“This is large-scale gene therapy for plants,” Whitham said.
The concept works like this: The researchers would engineer viruses that would then be introduced to corn plants through the bite of aphids, tiny insects that feed on the sap of plants. As the viruses infect the corn plants, they activate genes in the corn that would help the plants fight stress brought on by drought or a range of other problems. The researchers say such a process could be deployed much faster than the use of traditional plant breeding to develop stress resistance.
Miller said deploying viruses and insects in this manner would require years of testing for safety and environmental purposes, so farmers shouldn’t expect to make use of the research any time soon. But simply studying viruses in this manner could yield new insight into how they infect crops and other plants, he said.
“Regardless of the end result, we will learn a lot about how viruses interact with insect vectors and plants,” Miller said. “We expect the research will shed new light onto how to safeguard food production from evolving threats.”
The work is part of DARPA’s Insect Allies program, which seeks to ensure food security by developing quickly deployable alternatives to traditional responses to crop stress to safeguard food production. Miller stressed that the researchers will adhere to strict safety procedures throughout the project, which will not involve environmental release. The final phase of the testing will occur in tightly controlled greenhouses at the University of California, Davis.
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