Bringing usability to gradients and chiral compounds
In convergence chromatography, the separation is achieved by manipulating the density and composition of a supercritical fluid-based mobile phase. Because of the very high diffusivity of the mobile phase, high separation efficiency and fast gradient formation can be achieved. Additionally, the diversity of stationary phase and mobile phase (co-solvent) options provides access to the largest selectivity space available to any separation technique.
Diverse applicability and selectivity
Convergence chromatography utilizes the same eluotropic spectrum as normal-phase LC. The flexibility of this technique, however, also allows the use of some conventional reversed-phase columns, such as C18, yielding similar retention characteristics to reversed-phase LC when analyzing highly lipophilic compounds.
Convergence chromatography and the ACQUITY UPC2 System
The ACQUITY UPC2 System is a holistically designed convergence chromatography system that utilizes liquid CO2 as the primary mobile phase, and is the first analytical system purposefully designed to manage supercritical fluids. The system leverages the chromatographic principles and selectivity space of normaI-phase LC while providing the ease-of-use of reversed-phase LC, enabling you to address routine and complex separations challenges. Built upon proven, low-dispersion, high-efficiency UPLC technology, the ACQUITY UPC2 System offers a level of reliability, robustness, sensitivity, and throughput never before possible.
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