Product Application News

Gas generators are a green solution for analytical labs

The unusual characteristics of these abundant, bacteria-killing viruses could lead to evolutionary insights

Reaction screening and purification are essential steps in small molecule pharmaceutical discovery labs.

Mercury is a toxic element found throughout the environment. Its mobile nature allows it to diffuse through the air, soils and ultimately into water systems. Fish have the ability to bio-accumulate mercury (in its methylated form) at much higher concentrations than the waters they inhabit. People and wildlife that consume fish high in mercury are at risk.

Epigenetic modifications are defined as heritable information other than nucleotide sequences (1) that have the ability to control how and when transcription takes place. DNA methylation and secondary DNA structures such as DNA Gquadruplexes are among the epigenetic modifications currently under study because of their common associations with cancer (1,2).

The Extraction System B-811 and the Syncore Analyst parallel concentrator as well as the Pressurized Solvent Extractor were evaluated for the pretreatment of samples containing polycyclic aromatic hydrocarbons (PAHs).

Almost all drug compounds will elicit deleterious effects on cells at some concentration. Lysosome perturbation as a result of ion trapping of amine containing compounds has been demonstrated to cause the formation of autophagosomes and autophagic cytopathology. Here we describe the use of the EL406 Combination Washer Dispenser to automatically aspirate media, wash cells and dispense reagents for the Lyso-ID Red Detection kit, part of the CELLestial Live Cell Analysis platform from Enzo Life Sciences.

Wine is one of the oldest cultural products in human history. Vines have been cultivated for over 8000 years. The oldest known archaeological evidence of winemaking is an 8000-year old wineand fruit press found near Damascus. Awareness of the medicinal effects of wine also date back to this time.

In toxicology studies, alterations to the intrinsic in vivo biochemical profile of an animal can be monitored via NMR spectroscopic analysis of urine. Chemometric processing of the NMR data can enhance understanding of the toxic effects; in particular, examination of the principal component analysis (PCA) scores provides insight into these data in a time-efficient manner.

The advent of high throughput techniques have had a profound effect on pharmaceutical companies and the drug discovery process worldwide. The numbers and types of compounds available for elucidation have increased by orders of magnitude.