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Webinar: Webinar: Molar Mass, Size, Charge, and Interactions: Light Scattering Tools for Essential Biophysical Characterization

Webinar Details
Webinar: Molar Mass, Size, Charge, and Interactions: Light Scattering Tools for Essential Biophysical Characterization
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This seminar will review light scattering technology and instrumentation, then present select examples illustrating how complete light scattering solutions facilitate rapid and effective development of biologics including mAbs, ADCs, PEGylated, and other proteins as well as viruses, VLPs, and nanoparticle drug-delivery vehicles.

Live Air Date: Tuesday, March 31, 2015

Biophysical techniques based on static and dynamic light scattering address many of the key analytical challenges in biotherapeutic R&D, from early candidate selection through scale-up, formulation, characterization, and comparability studies. This seminar will review light scattering technology and instrumentation, then present select examples illustrating how complete light scattering solutions facilitate rapid and effective development of biologics including mAbs, ADCs, PEGylated, and other proteins as well as viruses, VLPs, and nanoparticle drug-delivery vehicles.

As an attendee, you will learn more about:

  • How size-exclusion chromatography coupled to multi-angle light scattering (SEC-MALS) is used to determination of molar mass, size and composition for biopolymers and protein conjugates
  • How field-flow fractionation coupled to MALS (FFF-MALS) is used to perform high-resolution characterization of size, conformation and composition of virus, VLP, liposome, and emulsion nanoparticles as well as sub-micron protein aggregates, by FFF-MALS
  • How high-throughput dynamic light scattering (HT-DLS) carried out in microwell plates is utilized in biotherapeutic formulation and stability studies
  • How electrophoretic light scattering (ELS or PALS) can determine molecular charge or nanoparticle zeta potential in standard formulation conditions to enhance formulation studies of biologics and vaccines
  • How label-free, immobilization-free analysis of antigen-antibody and more complex biomolecular interactions is readily accomplished by composition-gradient MALS (CG-MALS)

Speaker

Daniel Some, PhD - Principal Scientist, Wyatt Technology Corp

Sponsor