Original Broadcast Date: Thursday March 3, 2016
The tableting process is a multi-step process with several operations to convert raw material into an effective formulation. Fluid bed granulation is widely used to produce solid dosage forms. In-line NIR spectroscopy is used to determine the granule moisture content and particle size. One of the key measurements of product quality is the standard active content uniformity test. Traditionally, samples are taken from the various stages of the process and analyzed using time-consuming methods for active pharmaceutical ingredient by HPLC, which requires tedious sample preparation and recycling of hazardous solvents.
In this webinar, Dr. Stephen Hoag, Professor of Pharmaceutical Sciences at the University of Maryland, Baltimore discusses the advantages that Near-infrared (NIR) spectroscopy offers over traditional instrumental analysis methods. NIR requires no sample preparation, allows recovery of intact sample, and offers rapid analysis. Implementing NIR for tablet assay increases the productivity of the tablet analysis and improves quality assurance of tablet production.
Key learning objectives:
- Tips & tricks from Dr. Hoag for implementing NIR for a continuous tablet manufacturing process
- Tableting processes and implementing NIR for granulation process
- Assay & content uniformity of tablets by transmission NIR
- Improving quality control of tablet manufacturing with NIR
Dr. Stephen Hoag
Professor of Pharmaceutical Sciences
Director, Good Manufacturing Practice Facility
University of Maryland School of Pharmacy
Dr. Keith Freel
Spectroscopy Product Manager