High-Performance Mass Spectrometry Using a No-Compromises Approach

LECO Corporation continues its history of innovation in high-speed time-of-flight mass spectrometry with the introduction of new High Resolution TOFMS (HRT) instrumentation, available in LC and GC configurations.

By

Introduction

LECO Corporation continues its history of innovation in high-speed time-of-flight mass spectrometry with the introduction of new High Resolution TOFMS (HRT) instrumentation, available in LC and GC configurations. Based on LECO’s exclusive Folded Flight Path™ (FFP™) technology, the HRT systems provide mass accuracy, acquisition speed, dynamic range, and resolution, all in one instrument and at the same time.

High Resolution LCMS and GCMS

Recognized with the 2011 Pittcon Editors’ Gold Award, the Citius™ LC-HRT offers several API sources and acquisition of 50-2500 m/z, 200 spectra/second, at 100,000 resolving power (FWHM) and < 1 ppm mass accuracy. Its novel ion optics provide the capability to generate and analyze fragment ions in a comprehensive fashion. Ions are effectively fragmented, similar to traditional in-source CID (isCID), with the same mass accuracy and resolution as available to parent ions in a distinct data channel. The GC-based Pegasus® GC-HRT provides acquisition capabilities of 200 spectra/second over the mass range of 10- 1500 m/z, with 50,000 resolving power and < 1 ppm mass accuracy.

In both HRT systems, signal acquisition is achieved using patented KADAS™ technology to provide information-rich, high-integrity output under demanding acquisition conditions. The combination of KADAS and FFP provide the capability for high-accuracy relative isotope abundance measurements for greater confidence in analyte identification. These advances in technology are paired with LECO’s exclusive ChromaTOF-HRT™ software, which utilizes True Signal Deconvolution® for accurate peak definition.

Versatile MS Options

In addition to HRT instrumentation, LECO’s existing portfolio of mass spectrometry products includes the TruTOF® HT GC-TOFMS, a highthroughput, benchtop GCMS that combines a fast acquisition mass spectrometer (80 Hz) with ChromaTOF® software, to provide revolutionary Time-Compressed Chromatography, Automated Peak Find, and True Signal Deconvolution ®. No other benchtop system can match the speed and accuracy of TruTOF, with the reliability customers expect from LECO.

For a higher performance system which can be upgraded to GCxGC, the Pegasus HT GC-TOFMS is available. This system combines LECO’s Time-of-Flight Mass Spectrometer with Chroma- TOF® software to provide revolutionary Time- Compressed Chromatography, Complex Sample Resolution, Automated Peak Find, and True Signal Deconvolution in a high-throughput GCMS.

For a more rigorous approach to GC separations, and to achieve higher information content, LECO offers the Pegasus 4D with comprehensive twodimensional gas chromatography (GCxGC). The 4D offers two dimensions of chromatographic separation, the information content of TOFMS, and the power of award-winning ChromaTOF software and True Signal Deconvolution, all in a seamless, easy-to-use package. When MS detection is not needed, GCxGC FID and/or ECD systems are available, with resolving power unmatched by traditional GC.

Conclusion

The LECO portfolio provides high-performance tools to answer the most demanding separation science challenges. Building on the success of LECO’s existing products, new HRT instrumentation makes it possible for laboratories to combine speed, resolving power, mass accuracy, isotopic abundance, and dynamic range in a single instrument.

Published In

Laboratory Etiquette Magazine Issue Cover
Laboratory Etiquette

Published: May 9, 2011

Cover Story

Laboratory Etiquette

Many lab managers still remember them from their student days—a handful of hastily stapled printouts sternly titled “Laboratory etiquette—Acceptable standards of conduct.” Those were rules to live by, and the smallest violation landed a budding laboratory scientist in front of the ticked-off chief instructor.