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Webinar

Assay to Aggregates: Chromatographic Workflows for Therapeutic Peptides and Their Unique Impurities

Join Lab Manager and our experts as we discuss analytical challenges across therapeutic peptide workflows.

Written byPhenomenex
Presented bySean Orlowicz andScott D. Hanton, PhD

Ask the Expert Webinar

Thursday, October 15, 2026
1 PM ET

Therapeutic peptides are a fast-growing pharmaceutical drug class, but they present unique analytical challenges due to closely related process impurities, degradation products, and higher-order aggregate species. This webinar shows how complementary chromatographic workflows can be used to address those challenges, with examples spanning assay, related substances, stability-indicating analysis, and aggregate assessment. Real-world applications will cover aggregation profiles of key GLP 1 receptor agonists including semaglutide, liraglutide, and tirzepatide.  

As an attendee, you will learn more about:

  • The main analytical challenges involved in therapeutic peptide characterization, including closely related impurities, degradation products, and aggregate species.
  • Where reversed-phase chromatography and size exclusion chromatography fit across therapeutic peptide development workflows.   
  • How different reversed-phase selectivities were used for semaglutide assay, related substances, and stability/degradant studies, and understand how similar workflows can be adapted for other GLP-1 analogs, including tirzepatide.

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