Articles by Howard Hughes Medical Institute

A new CRISPR-free tool brings gene editing power to cells' second, smaller genome—the one in their mitochondria

A new clinical trial will test a treatment that targets this overactive immune response

Rather than relying on optics, the microscopy system offers a chemically encoded way to map biomolecules’ relative positions

Current HIV therapy involves combinations of antiretroviral drugs, each of which inhibits a specific stage of the HIV lifecycle

An interferon cell receptor spurs cell suicide in mouse fetuses infected with Zika virus and could play a role in certain pregnancy complications

According to a new analysis, a year-long course called SEA-PHAGES has had a substantial impact on the way students think about science and themselves

A microscope lens implanted deep inside a mouse’s brain shows different patterns of neural activity when the mouse interacts with males, females, or other stimuli

A new type of DNA editing enzyme, developed in HHMI Investigator David Liu’s lab, lets scientists directly and permanently change single base pairs of DNA from A•T to G•C

The work offers scientists a way to adjust the properties of existing dyes deliberately, making them bolder, brighter, and more cell-permeable

HHMI scientists develop a much-needed genetic resource that is aiding development of wheat plants with improved traits