December 2015 Technology News

SLAS’s 5th annual international conference and exhibition gives attendees the chance to learn the latest and best practices for how to apply technology for life sciences research and development. Please note that the specific technologies featured here may not be at the show, but their manufacturers will be hand to answer your questions.

Analytical

r-Protein A Analytical Column

CIMac™

This short bed, high performance monolithic column is primarily intended for fast, efficient, and reproducible qualitative and quantitative analyses of immunoglobulin G (IgG)
Suitable for use with HPLC and UPLC systems • Quantification of immunoglobulin G is possible between 0.20 μg and 20 μg
Small volume and short column length allow operation at high volumetric flow rates (up to 3 mL/min)

BIA Separations www.biaseparations.com

Gel Filtration/Aqueous Size-Exclusion Column

Yarra 1.8μm SEC-X150

Designed for the separation of biomolecules on HPLC and UHPLC systems
New Yarra surface chemistry, combined with bio-inert column hardware, reduces sample adsorption compared to other GFC/SEC columns currently on the market
Provides improved recovery and more accurate quantitation of biomolecules
Features a wide molecular weight range (1 – 450 kDa) and high efficiency

Phenomenex www.phenomenex.com

GC Column

Zebron™ ZB-5MSPLUS™

Is a highly inert 5% phenyl-arylene phase GC column for challenging separations
Designed with rigorous fused-silica deactivation and quality control processes
Virtually eliminates active sites on the column’s surface that can negatively affect peak shapes for challenging compounds
Produces better peak shapes without retention time shifts, and ultimately increases a lab’s productivity

Phenomenex www.phenomenex.com

Mass Spectrometer

6500+ Series

Reaches ultra-low LOQs with trace sensitivity in both positive and negative ionization
Detects more compounds in every injection with ultra-fast polarity switching
Eliminates matrix interferences and improves selectivity with newly enhanced SelexION+ technology
Improves confidence with QTRAP® technology and enhanced workflows for fast MS/MS screening via library searching, MRM3, and more

SCIEX sciex.com

UV-Vis Spectrophotometers

NanoDrop One & NanoDrop OneC
Booth 707

Feature Thermo Scientific’s Acclaro Sample Intelligence technology
Allows researchers to identify sample contaminants and obtain corrected concentration results
Enables users to receive instant feedback about sample quality with on-demand technical support and guided troubleshooting
Include embedded sensor and digital image analysis
Sample-retention system measures 1-2 μL of sample in seconds without the need for cuvettes

Thermo Fisher Scientific www.thermoscientific.com

UHPLC/HPLC Columns

TSKgel® UP-SW3000

Offer dual functionality for use in both UHPLC and HPLC systems
Packed with 2 μm silica based particles and feature the same pore size as the well-established TSKgel G3000SWXL columns
Available in 4.6 mm ID with 15 or 30 cm length
The 15 cm column offers a shortened analysis time with improved efficiency while the 30 cm column delivers dramatically increased peak parameters

Tosoh Bioscience www.tosohbioscience.com

Basic Lab

Laboratory Convection Ovens

StableTemp™

Offer scientists several options to enhance their processes
Digital mechanical convection ovens quickly dry and heat samples and allow users to program and control through PC, if desired.
Economy mechanical convection ovens deliver forced air convection with PID temperature control
Economy gravity convection ovens provide gentle airflow for sterilization and drying

Cole-Parmer www.coleparmer.com

Permanent Magnet Motor

BGA22

Can be used in laboratory robotics and handheld devices
Measures just 22mm in diameter, 38mm in length, and weighs 0.065 kg
Provides an excellent power-to-size / weight ratio performance, so is ideal for smaller medical devices or other similar handheld equipment
Axial flux design has no cogging torque and therefore literally no vibration and quiet operation

Dunkermotoren www.dunkermotoren.de

Oxygen Flask Combustion Unit

Based upon the internationally-recognized Schöniger flask method
Designed for preparation of samples for single and mixed elemental analysis of chlorine, bromine, iodine, sulphur, and phosphorus content
Provides a safe and repeatable tool for combusting samples prior to elemental analysis by ion chromatography or titration
Unit remotely ignites samples inside a safety-interlocked chamber using focused infrared heat from two tungsten-halogen lamps

Exeter Analytical www.exeteranalytical.co.uk

Variable Speed Rotor Mill

PULVERISETTE 14 premium line

Offers impact, shearing, and cutting comminution in one instrument
Provides a fast sample throughput of up to 15 litres and more per hour, depending on the material and parameter settings
A high-speed motor with ceramic bearings ensures a particularly high impact and rotor speed with an extra powerful 22,000 rpm

FRITSCH www.fritsch.de

PVC Acid Digestion Fume Hood

UniFlow

Engineered specifically for extremely corrosive operations involving dissolution procedures for element analysis
Features a totally chemical resistant hood construction with a welded one-piece PVC interior fume chamber including hood walls, ceiling, work surface, and rear drain trough
Available in 48”, 60”, 72”, and 96” models, this series of fume hoods can be supplied with or without a built-in washdown system

HEMCO www.hemcocorp.com

Benchtop SEM

JSM-6000PLUS NeoScope

Delivers fast, high magnification electron microscopy with more functionality than typical benchtop SEMs
Now offers high sensitivity backscatter electron detection with a BSE detector manufactured by JEOL to detect contrast between areas of the sample with different chemical compositions
Features simple design with touchscreen operation
Ergonomic and easy-to-operate for a variety of applications

JEOL USA www.jeolusa.com

Potentiometric Titrator

COM-1700SC

Can run multiple titrator stations that easily allow the end user to do different types of titrations including potentiometric, photometric, polarization, and conductometric titrations in parallel
Users can add a model C-2012 automatic sample changer to increase sample throughput, automate pH calibration, and wash and prepare the electrodes for the next sample analysis

JM Science www.jmscience.com

Vacuum Pump Controller

VC 900
Booth 339

Compatible with all vacuum sources and is easy to use
Enables control of vacuum application
Enhances reliability and precision
Features a separate, independent control unit

KNF Neuberger www.knfusa.com

Entry Level Balance

ME-T

Offers a reliable, high-performance weighing cell and a large, intuitive 4.5’’ color TFT screen
Includes three interface connections for easy data handling
Suited for day-to-day weighing in any lab or manufacturing environment where value for money has high priority
Built-in applications and an intuitive user interface make the balance convenient and easy to use

METTLER TOLEDO www.mt.com

PID Controller

CNPT-DEMO

Offers a fully integrated temperature control system suitable as a platform to investigate the use of closed loop (PID) and simple on/off temperature control in heating and cooling applications
Suited for PID control theory education in universities and laboratories
Easy to set up and use with intuitive “smart” menu flow, panel-mounted USB, and Ethernet connectivity

OMEGA www.omega.com

HPLC Pump

LU Class

Consists of dual-headed, positive displacement piston pumps delivering accurate flow rates at extremely high pressures
Available fluid path materials are stainless steel and titanium for standard and bio-compatible UHP chromatography applications
Features a pressure capability of 18,000 psi, with a maximum flow of 5 mL/min
Provides high flow accuracy over the entire pressure range

Scientific Systems ssihplc.com

Chilling/Heating Dry Bath

EchoTherm™ Model IC50
Booth 1247

Peltier-driven, with exact sample temperature control
Supplied with a temperature probe to insert directly into the sample or into the sample block
Probe senses the sample temperature or sample block temperature directly and sends that information to the unit to drive and control the temperature exactly where set
Displays and controls temperature to ±0.1°C Entry Level Balance

Torrey Pines Scientific www.torreypinesscientific.com

Informatics

HLA Analysis Software

Axiom™

For automated, high-resolution human leukocyte antigen (HLA) typing from any genotyping dataset containing coverage of the extended major histocompatibility complex (MHC) region
Software’s unique imputation algorithm enables 4-digit HLA typing from genome-wide association studies (GWAS), combining genotyping and high-resolution HLA typing into a single assay
Provides simple, ‘push-button’ analysis to dramatically decrease researchers’ cost and workload

Affymetrix www.affymetrix.com

Spectroscopy Software

KnowItAll® 2015

Features “Optimized Corrections” technology that performs a computationally complex set of corrections on all query and reference spectra in a search to find the optimal match between the query and each reference spectrum
Also features two new software applications as well as the addition of spectra to its collection of Bio-Rad spectral databases that include KnowItAll QC Expert™, KnowItAll Deformulation Expert™, and new spectral data

Bio-Rad www.bio-rad.com

Flash Purification Interface

Isolera™ Assist

Provides a structured guide for users resulting in consistent purification conditions and an intelligent way to select optimal cartridges based on crude sample mass and TLC data
Available to all Isolera instruments
Simplifies the setup procedure of a purification run, incorporating intelligence that guides the user to utilize the system in the most economical way

Biotage www.biotage.com

Control Driver for Mass Detector

Clarity

The Microsaic 4000 MiD control module includes both digital control and data acquisition for the detector
Includes MiDas compact interface module controls and allows users to perform detector calibration, maintenance, and service operations from the Device Monitor software window
Provides seamless integration of Microsaic 4000 MiD with a wide range of HPLC systems that are already controlled by Clarity

DataApex www.dataapex.com

Spectroscopy Software Module

ProtectionPlus
Booth 1452

Designed for the LabSpec 6 Spectroscopy Suite
Fully integrated module seamlessly adds a layer of security and data integrity controls that enable compliant use of HORIBA Raman microscopes within regulated laboratory environments
Offers a configurable module for system security administrators to put in place and enforce a wide range of security, user, and file policies

HORIBA www.horiba.com

Sample Management Software

FreezerPro® Cloud
Booth 852

Available by subscription Software-as-a-Service
Requires no installation or IT resources of any kind
Offers the choice between public and private cloud, and includes many enterprise security features in all editions, such as SSL (secure socket layer) and 1,028 bit encryption, advanced persistent threat monitoring, virus scans, backups, and other premium services

RURO www.ruro.com

Lab Automation

Desktop X-ray Microtomograph

SKYSCAN™ 1275
Booth 1348

Takes advantage of new X-ray source technology and efficient flat-panel detectors to reduce scan time to just a few minutes, without compromising image quality
Push-button operation with a preselected sequence of actions, including scanning, reconstruction, and volume rendering means that even routine users can successfully obtain high-quality results
Features an object size range up to 96mm in diameter and 120mm in length

Bruker www.bruker.com

Automated Positive Pressure Extraction & Evaporation Module

[MPE]²
Booth 807 (Hamilton Company)

Cost-effective solution combines automated positive pressure SPE and evaporation in one device
Integrates with all Hamilton automated liquid handling workstations
Small footprint is scalable for increased throughput and walkaway time
Patented design fits most filter/ collection plate combinations and includes pressure control up to 100 psi

Hamilton Robotics www.hamiltoncompany.com/slas

Microtube and Cryovial Storage Racks

RackWare HD138 and HD60
Booth 807 (Hamilton Company)

These high-density SBS-footprint racks are designed for use with Hamilton’s BiOS, SAM and Verso sample management and storage systems
Increase the storage capacity in a given space by increasing the number of tubes that can be placed in an SBS-footprint rack
RackWare HD138 increases storage capacity in a comparable SBS footprint from 96 to 138 tubes, while HD60 increases the storage from 48 to 60 larger cryovials

Hamilton Robotics www.hamiltoncompany.com/slas

Life Science

Transplant Genotyping Array

Axiom®

Designed to improve transplantation success and individualize donor/patient selection and treatment
Comprises ~ 780,000 markers, including over 30,000 variants that may contribute to transplant rejection or other complications
Meta-analyses may be conducted, combining data with other genotype databases such as the UK Biobank cohort, a collection of more than 500,000 volunteers genotyped using the Affymetrix UK Biobank Axiom Array

Affymetrix www.affymetrix.com

Next-Generation Sequencing Instrument

4200 TapeStation
Booth 1007

This fully automated instrument enables scientists to rapidly analyze up to 96 DNA samples at a time
Addresses the need for both higher throughput and higher quality in next-generation sequencing labs
Allows end-to-end quality control of samples and libraries in any sequencing workflow, using any number of samples from one to 96, at a constant cost per sample

Agilent Technologies www.agilent.com

PCR Thermal Cycler

qTOWER³
Booth 517

Patented fiber optic shuttle system with unique light source powered by 4 high-performance LEDs guarantees ideal excitation and detection of known fluorescent dyes up to the dark red
System’s highly sensitive detection module can be equipped with up to 6 different color modules
Silver block technology offers homogeneity of only ±0.1°C over the entire 96 well block

Analytik Jena www.analytik-jena.com

Thermal Cyclers

StableTemp

Enable scientists to program PCR processes for easier operation
Include two- and three-step PCR, RT-PCR, chill, and ligation program templates
For greater flexibility, users can switch out thermal blocks to adapt to their changing lab needs
Safety features include password protection of saved setting configurations and temperature cycle programs to prevent tampering and accidents

Cole-Parmer www.coleparmer.com

Kits for Bioprocess Analysis

Gyrolab™ CHO-HCP Kits 2-5 and Gyrolab Human IgG Titer Kits

Four new Gyrolab CHO-HCP Kits 2-5 quantify host cell proteins (HCP) from Chinese hamster ovary (CHO) cells used in bioprocessing of biotherapeutics
Gyrolab huIgG Kits, for determination of human IgG, come in two configurations, High Titer and Low Titer, have been developed to accurately and robustly quantify intact human IgG (IgG1, IgG2 and IgG4) during cell line development

Gyros www.gyros.com

CRISPR-Cas9 System

Alt-R™

Improves genome editing potency thanks to research-optimized crRNAs (CRISPR RNA) and tracrRNAs (trans-activating crRNA)
Features improved potency and safety
Saves time by providing easy, ready-to-use RNA reagents that also reduce cell toxicity by avoiding activation of cellular innate immune responses
Useful for very clean manipulations in cells, as it doesn’t leave a footprint that could cause undesired changes to the genome

Integrated DNA Technologies www.idtdna.com

Cell Culture Medium

BalanCD® Transfectory™ CHO

For rapid, scalable production of recombinant proteins through transient transfection in CHO cells
Chemically-defined and animal component free
Has been specifically designed to support sustained, high growth with increased transfection efficiency that can yield gram-scale protein expression
The ability to obtain gram-scale yields by transient transfection in CHO cells is a real step forward towards cutting costs and development time for biotherapeutic research

Irvine Scientific www.irvinesci.com

Supplies & Consumables

1.40ml Round Bottom Tubes

Booth 207

Feature a working volume of 1.14ml
Available in non-coded or alphanumeric coded versions
Provide an affordable way to improve sample storage, handling, and logistic processes
Can be purchased in bulk lots, refills or racked for 96-tube format use in the Comorack-96 or the fully automation-compatible

Roborack-96 Micronic www.micronic.com

96-Well Plates

Strata-X μElution

Enable solid phase extraction from samples as small as 10μL, along with low elution volumes
Conserve precious samples and reduce time requirements compared to traditional SPE plates, which require 200 μL elution volumes and a dry-down step to produce sufficient concentration
Follow the same procedure as traditional 96-well SPE plates, however elution volumes are as low as 25μL, eliminating the need to perform a dry-down step

Phenomenex www.phenomenex.com

Single-Use Bags

Flexsafe® 3D Pre-designed Solutions
Booth 1223

Meet all the functional and validation requirements of the biopharmaceutical industry
Feature the appropriate components, functionalities, and quality controls that meet the specific requirements of each step in upstream and downstream processing and in final filling
Available in a range of sizes from 50L to 1,000L and are made of robust, yet highly flexible, 400 μm thick co-extruded film structure

Sartorius Stedim Biotech www.sartorius-stedim.com