September 2016 Technology News

Analytical

Triple Quadruple ICP-MS System

8900

The controlled-reaction chemistry of this inductively coupled plasma/mass spectrometry system delivers the lowest detection limits for previously difficult elements, such as sulfur, silicon, and phosphorus
Includes a fast detector that sets a new benchmark for single nanoparticle applications
Features ICP-MS MassHunter software

Agilent www.agilent.com

Self-Cleaning Ion Source

JetClean

The first commercially available ion source that cleans itself
Designed to keep Agilent quadrupole gas chromatography/mass spectrometry systems free of matrix deposits that would otherwise build up over time and degrade instrument performance
Using a carefully controlled hydrogen flow, JetClean technology greatly reduces—or even eliminates—the need for source cleaning on Agilent single and triple quadrupole GC-MS systems

Agilent www.agilent.com

Spectrophotometers

Novaspec III+ and Novaspec Pro

Compact, lightweight, and ergonomically designed • Include a large display that is easy to read and a simple user interface for rapid set up and analysis
Novaspec III+ is an entry level visible spectrophotometer for labs performing basic spectroscopy measurements
Novaspec Pro includes the same abilities as the III+, but adds multi-wavelength measurements and life science methods

Biochrom www.biochromspectros.com

Ultra-High Throughput Mass Spectrometer

rapifleX™ MALDI PharmaPulse™

Can dramatically lower the cost of ultra-high throughput screening (uHTS) with further improved results
Offers the speed, specificity, and robustness of mass spectrometry for large primary screens
Compared to existing LC/SPE-MS HTS solutions, the system is 100-1000x faster and uses about 100x less solvent, without the need for LC columns and other LC consumables

Bruker www.bruker.com

Mass Spectrometer

timsTOF™

Combines very high ion mobility resolution greater than 200, using Bruker’s proprietary Trapped Ion Mobility Spectrometry (TIMS), with Bruker’s ultra-high performance ESI-QTOF mass spectrometry
A flexible, research-grade instrument for optimal separation and analysis of unresolved compounds and conformations
Allows separation of isomeric compounds, accurate determination of collisional cross sections and gas-phase protein structure and aggregation studies

Bruker www.bruker.com

Sample Pretreatment Module for LC-MS

CLAM-2000

Automatically performs all of the processes necessary for analyzing blood and other biological samples, from scanning in information from the blood collection tubes to sample pretreatment and LC-MS analysis
First truly integrated sample preparation system for LC-MS that allows users to process samples in an instrument that is directly attached to the LC-MS system
Helps to facilitate a safe working environment

Shimadzu www.ssi.shimadzu.com

MS-MS Hybrid Quadropole- Orbitrap Mass Spectrometer

Q Exactive BioPharma

Enables three powerful workflows (denatured and native MS intact analysis, subunit and top/ middle-down analysis, and peptide mapping) for the complete characterization of biotherapeutics
Encompasses all of Thermo Scientific’s leading technologies into one system
Features a new High Mass Range (HMR) mode

Thermo Fisher Scientific www.thermofisher.com

Basic Lab

Discrete Analyzer

Smartchem 600

Can perform up to 600 tests/hour
Utilizes washable cuvettes with an integrated wash and control station, which guarantee a lower running cost and reduced risk of contamination
Offers automated system quality control in addition to automated analysis
Provides reduced hazardous waste management cost, reduced volume of waste, and low energy and water consumption

AMS Alliance www.amsalliance.com

Vortex Mixer

Stuart SA6

Robust, with die cast construction
Features a sophisticated inbuilt counterbalance system as well as suction cup feet to prevent any walking issues, which are often associated with budget vortex mixers
Mixing speed ranges from 2500 to 4500 rpm, making the mixer suitable for a range of applications

Bibby Scientific www.bibby-scientific.com

Canopy Hoods

Designed to collect and exhaust corrosive vapors, heat, steam, and odors
Available in 36”, 48”, 72,” and 96” widths, in wall or island models
Also available in either molded, chemical-resistant, flame retardant, one-piece composite resin, or fabricated of welded type 304 stainless steel
Wall canopy hoods include a wall mounting kit

HEMCO www.HEMCOcorp.com/canopy.html

8- and 12-Channel Manual Pipettes

EVOLVE

Pipette range now includes 8- and 12-channel versions
Unlike traditional pipettes which utilize a single rotating plunger to set volumes, the EVOLVE features three adjustable dials for setting each individual volume digit
Cover a volume range of 1 – 200 μl
Able to enhance productivity and comfort even during prolonged pipetting sessions

INTEGRA www.integra-biosciences.com

Heating Stage

HS1500

Can control sample temperatures up to 1500°C whilst maintaining a clear optical path for observing any changes in its characteristics
Incorporates a large window that can be rotated to move a clear area into the optical path
Features a ceramic heating cup which when used in conjunction with the ceramic cover creates a micro oven around the sample and heats at a rate of up to 200°C/min

Linkam www.linkam.co.uk

Tube Selector

Offers the convenience of single-handed operation and the possibility to manually pick individual tubes from any tube storage rack without the necessity of lifting them
Enables 'hands-free' manual picking and placing for labs looking to reduce contamination
Easy-wipe-clean surface further reduces the chances of sample contamination
Available as a low cost stand-alone product or as part of a starter pack

Micronic www.micronic.com/product/tube-selector

Peristaltic Pumps

Perimax 12 and Perimax 16

Differ only in the number of rollers (12/16) in the pump head and the continuously adjustable flow rates they can achieve (0.0017 mL/min to 20 mL/min against 0.0034 mL/min to 40 mL/min)
16-roller pump produces no measurable pulsation
Easy to use—the tube is guided around the pump head and its two ends are fixed to a special mechanism

Spetec www.spetec.de

Tempered Glass Modular Cleanroom

BioSafe®

This free-standing, hardwall room is made of transparent glass panels attached to a stainless steel frame • Meets cleanliness ratings down to ISO 5
Is non-sloughing, non-outgassing, and chemical-resistant, making it ideal for aseptic processes and frequent decontamination
Ceiling grid supports electrical modules including LED or fluorescent lights, and HEPA or ULPA fan/filter units

Terra Universal www.TerraUniversal.com

Cell Culture

Research Tools for PD-1 Checkpoint Inhibitors

New cell lines and controls for programmed cell death protein 1 (PD-1) research, and to test inhibitors of the PD-1 / PD-L1 pathway, are now available
A PD-1 / NFAT Reporter - Jurkat cell line is for applications including screening for activators or inhibitors of PD-1 signaling in a cellular context
The TCR activator / PD-L1 - CHO recombinant cell line is purpose-designed for screening for activators or inhibitors of PD-1 signaling, and more

AMSBIO www.amsbio.com/immunotherapy.aspx

Benchtop Scale Fermentation Systems

proSET

Designed to provide an optimized cell cultivation solution for applications including growth of sensitive and fragile mammalian and insect cells
Incorporate a large, color touchscreen panel with an intuitive software interface for ease of use
Heating system allows operators to use any fermentation vessel type up to 20 liters, enabling a wide range of applications to be undertaken

Cleaver Scientific www.cleaverscientific.com

Cell Culture Vessel

CELLdisc

Offers large growth surfaces on a small footprint and facilitates the scale-up of mass cell cultures
Compact, robust, and cylindrical design means CELLdisc is just as suited to smaller test series as it is for automation and the quantifiable scale-up of mass cell cultures in sizes of between 1,000 and 10,000 square centimetres
Ergonomic design simplifies the cultivation of mammalian cells

Greiner Bio-One www.greinerbioone.com

Cell Culture Media Filter

Virosart® Media

Offers a fast and cost-effective solution for manufacturers to reduce the risk of virus contamination resulting from raw materials, such as chemically defined media, during fermentation
This single-use filter provides a high level of safety for customers’ upstream processes as it is qualified for > 4 log10 reduction of small, non-enveloped viruses (e.g., MVM) and as a mycoplasma and leptospira retentive filter

Sartorius Stedim Biotech www.sartorius.com/virosart-media

96-Well Cell Culture Plate

Nunc Edge

Designed to virtually eliminate the edge effect during lengthy incubation
Even after long incubation periods of up to four days, the overall plate evaporation rate is reduced to less than 2 percent
Allows all samples per plate to be analyzed, increasing assay performance with potentially less cost and related product waste
Eliminates well-to-well variability

Thermo Fisher Scientific thermofisher.com/edgeplate

Chemicals, Kits, and Reagents

CRISPR gRNA Lentivector Cloning Kits

Provide scientists with a targeted and precise genomic gene editing methodology
Include the standalone premade Cas9 expression lentivirus, and the gRNA lentivector cloning kits from which users can construct their desired target gRNA lentivectors
Enable rapid, precisely directional cloning of user’s DNA duplex encoded gRNA structure at efficiencies of greater than 95%

AMSBIO www.amsbio.com/lentivirus.aspx

Residual DNA Quantification Kits

ddPCR™ CHO & ddPCR™ E. coli

Simplify the quantification of host-cell DNA (HCD) in process development, quality control, and biomanufacturing processes
Allow for direct quantification of host-cell DNA impurities in biopharmaceuticals purified from bacteria (E. coli) or mammalian cells (Chinese hamster ovary) without the need for upfront nucleic acid purification steps
Designed for use with Bio-Rad’s Droplet Digital™ PCR systems

Bio-Rad www.bio-rad.com/RDQKits

cDNA Synthesis Kit

RTScript™

Allows users to produce robust cDNA yields in as little as 30 minutes
Is a modified version of M-MLV Reverse Transcriptase with RNase H activity deactivated and increased thermal stability
Sensitive, specific, and capable of synthesizing highly structured and long cDNA fragments
Optimized to offer high reproducibility and efficiency for a broad range of primers and templates

Empirical Bioscience empiricalbioscience.com

Tris SDS PAGE Running Buffer

Fisher BioReagents FastRun

Designed for use at higher voltages than traditional buffers, providing gradient-like electrophoretic separations of protein samples in nearly one-third less time
Provides comparable or better resolution and an increased molecular weight separation range of proteins when compared to traditional Tris-Glycine-SDS buffer
Reduces the number of Tris-Glycine polyacrylamide gel compositions required to resolve a protein, saving researchers time and money

Thermo Fisher Scientific www.fishersci.com/fastrunsdsbuffer

Informatics

Automated Metabolite Identification Platform

MetaSense

Combines comprehensive metabolic transformation prediction with efficient analysis of LC-MS analytical measurements to identify, visualize, and report chemical biotransformations
Will yield faster, easier, and more accurate detection and identification of predicted and unexpected metabolites
Built on the ACD/Spectrus platform and offers knowledge management capabilities that allow the information gained in metabolite studies to be applied in other areas of R&D

ACD/Labs www.acdlabs.com

Chromatography System Software

ChromLab™ Software Version 4.0

When used with Bio-Rad’s NGC chromatography system, the software version enables researchers to purify their proteins with ease
Scouting wizard allows researchers to easily automate method optimization
Enables control of multiple NGC systems from a single computer, further reducing the system’s footprint
Allows simpler purification, quick onboarding of new users, and easier data analysis

Bio-Rad www.bio-rad.com/proteinpurificationsolutions

Web-Based Chemistry ELN

E-WorkBook for Chemistry Module

Designed to support synthetic organic workflows in discovery chemistry
Strengthens IDBS’ existing web capabilities, and follows on from a strategic technology partnership with ChemAxon announced in 2015
Intuitive working environment covers all aspects of chemists’ workflow, including support for reaction planning, stoichiometry, molecule naming, semi-automated procedure write-ups, inventory lookup, and compound registration

IDBS www.idbs.com

LIS Solution

LimitLIS®

Includes secure, sharp, and easily understood client/patient portals to modernize the laboratory’s web presence
Features paperless e-requisitions, allowing clients to submit test orders online directly to the user’s lab, complete with patient information, billing details, and point of care tests
Offers bidirectional and unidirectional integration with analyzers and seamless integration with EHR and billing providers

RURO limitlis.cloud

Dynamic Fielding Feature for Image Capture Software

Now included in GeneSys image capture software
Autocorrects for edge effects caused by all lens and lighting in image analyzers, providing a consistent image for scientists to accurately quantify DNA and proteins on their gels
Saves scientists the time and effort of re-running gels to check their protein and DNA quantification results

Syngene www.syngene.com

PCR Set-Up Software

Designed for Tecan’s D300e digital dispenser
Offers new functionality and extends the D300e’s flexibility for genomics workflows
Features a PCR Wizard that guides the user through qPCR set-up
The D300e provides picoliter to microliter non-contact dispensing of liquids directly into assay plates and offers accurate and reproducible plate generation

Tecan www.tecan.com/d300e

LC-MS Data Analysis Software

Symphony Software

Allows users to easily link tasks into a sequence to build the data processing pipelines that they need for their laboratories
Provides time savings in data processing and automated analysis for out-of-hours working
Minimizes user errors in repetitive tasks and is future proof, allowing use of the latest algorithms
Helps maximize the return from LC-MS instrumentation

Waters www.waters.com

Lab Automation

Cartridge Extractor

SmartPrep Cartridge Extractor II

Designed for method development and automation of previously developed manual methods
Positive pressure consistently delivers the sample and solvents, yielding reproducible unattended results
Cartridges of 1, 3, and 6-mL size from most manufacturers can be used in the system, easing the transition to automation
Designed for special environmental applications

Horizon Technology www.horizontechinc.com

Robotic Gripper

The Gripster

This patented electro servo gripper is used in a wide range of robotic systems
Handles microwell plates without dropping, crushing, or otherwise mishandling them
Detects the presence of an object, such as a microwell, based on force rather than a sensor; once force is detected, power is held constant, eliminating the risk of crushing
Only a small amount of current is required

Let’s Go Robotics www.letsgorobotics.com

Nitrogen Blowdown Evaporator

Ultravap Levante

Comes with an RS232 connection and a remote command set enabling it to connect to and be operated from most commercially available robotic liquid handling systems
Features full-color touchscreen graphic displays, an integrated auto-ranging power supply, and built-in solvent fume venting
Also offers multi-step ramped programming with full alphanumeric program naming

Porvair Sciences www.porvair-sciences.com

Automatic, High Throughput Viscometer

VROC® initium

Equipped with automatic sample loading and sample cleaning
Measures absolute viscosity as a function of shear rate across a wide temperature range, allowing unique viscosity fingerprinting of the samples
Enables samples in 96-well plates as well as 40-vial racks to be tested automatically with intuitive software
Also measures viscosity for sample volumes as little as 10 microliters

RheoSense www.rheosense.com

Life Science

Slide Hybridizer

RapidFISH

Designed to simplify fluorescent in-situ hybridization (FISH) procedures for FFPE (formalin fixed paraffin embedded tissue) samples, cell suspensions, and other tissue preparation procedures
Features a self-clamping slide tray design that maintains the required humidity
Microscope slides in the RapidFISH do not require coverslips to be glued because the removable tray of the slide incubator traps moisture in the system

Boekel Scientific www.boekelsci.com

Single-Use Vessels

BioBLU®3f

Developed specifically for microbial bioprocessing in working volumes of 1.25 to 3.75 L, extending the full range of operation for single-use fermentation from 60 mL to 3.75 L
Address the demands of high cell density fermentation of bacteria, yeasts, and fungi
Robust magnetic overhead drives featuring Rushton-type impellers support agitation rates up to 1200 rpm and provide high-performance mass transfer

Eppendorf www.eppendorf.com/BioBLUf

Transfection Unit

4D-Nucleofector™ LV

Expands the proven 4D-Nucleofector™ system to closed, larger-scale transfection of up to 1x109 cells
Transfection protocols can be established in smaller scale using the 4D-Nucleofector™ X unit and smoothly transferred to larger scale without the need for re-optimization
With this new addition, small- and large-scale transfection applications are now united in one system based on the Nucleofector™ technology

Lonza www.lonza.com

FISH Probes

Cytocell Aquarius®

Nine new probes now available: ETV6 Proximal Probe Green, ETV6 Distal Probe Red, MPO Probe Red, TP53 Probe Green, NUP214 Probe Red, DEK Probe Green, TAS2R1 (5p15.31) Probe Green, Chromosome 9 Satellite III Probe Aqua, and Chromosome 15 Alpha Satellite Probe Red
Produce specific, high-intensity signals with excellent contrast and minimal background
Optimized for use on common sample types

Oxford Gene Technology www.cytocell.com

Bioreactor System

ambr® 250 modular

This benchtop mini bioreactor system is designed for parallel fermentation or cell culture
Combines a unique single-use bioreactor vessel and expandable system design to offer bioprocess scientists access to advanced benchtop bioreactor technology for process development
Consists of a workstation with 2, 4, 6, or 8 single-use bioreactors, with a working volume range of 100 to 250 mL

Sartorius www.sartorius.com

Supplies and Consumables

On-Line SPE Cartridges

ISOLUTE® ENV+

Designed for use primarily in integrated SPE-HPLC-(MS-MS) systems
Contain either EVOLUTE® EXPRESS ABN or ISOLUTE® ENV+ sorbents and consist of a stainless steel cartridge with standard HPLC compatible end fittings
Allow sample preparation to be fully integrated into an automated analytical workflow
Aimed primarily at the environmental market for extraction of trace organic analytes from water samples

Biotage www.biotage.com

Bottletop Dispensers

BRAND Dispensette® S

Feature improved safety valves, faster priming, easier volume selection, and even lower operation forces
All seals have been eliminated to have even less wearing parts to replace over time
A large variety of bottle adapters and accessories adapt the Dispensette® S to virtually any unpressurized application
Models are available for general purpose dispensing, organics and concentrated acids, and trace analysis

BrandTech Scientific www.brandtech.com

Super Precision Vessels for Dissolution Testers

SPV™

Designed for Hanson’s Vision G2™ series of dissolution testers
With its closer conformance to an ideal vessel shape, these vessels provide more consistent vessel-to-vessel dissolution test results in USP Apparatus 2
Resolves issues relating to routine calibration of dissolution testing equipment
Available in 1-liter vessel capacities, clear or amber, for the SR8-Plus, Vision G2 Classic 6, and Vision G2 Elite 8 dissolution testers

Hanson Research hansonresearch.com

Amber-Tinted Polypropylene Storage Tubes

Now available in 0.75ml and 1.40ml volumes
When used in conjunction with a secure screw cap or push cap, these tubes ensure the integrity of light sensitive biological samples even over long-term storage periods
Available in non-coded and laser encrypted 2D coded formats
Supplied in a 96-position sample tube storage rack that meets the ANSI / SLAS standard footprint

Micronic www.micronic.com

β-Glucuronidase Removal Tubes & 96-Well Plates

β-Gone

Designed for the cleanup of hydrolyzed urine samples in less than one minute
Offers a simple, rapid solution for β-glucuronidase removal that improves assay performance and column lifetime, and reduces mass spec maintenance
Also offers a better alternative to the “dilute-and-shoot” method in which sensitivity and accuracy are compromised when the sample is diluted

Phenomenex www.phenomenex.com

Septa

Thermolite Plus

Ultra-low bleed characteristic of these new septa minimizes the background signal, and the plasma coating prevents the septa from sticking in the injection port
Precision molding ensures a consistent, accurate fit
Select septa feature a CenterGuide design to minimize coring
Usable up to 350°C and come preconditioned and ready to use

Restek www.restek.com/ThermolitePlus

Black and White ELISA Plates

Provide medium binding surfaces for hydrophobic interactions and high binding surfaces for more hydrophilic interactions
Inclusion of white and black ELISA plates in the Sarstedt product line provides greater flexibility for use with a variety of ELISA detection methods
New white plates are especially recommended for performing luminescence measurements, and the black ELISA plates are recommended for performing fluorescence measurements

Sarstedt www.sarstedt.com