December 2015 Technology News
This month we feature companies that will be exhibiting at SLAS2016, which runs January 23-27, 2016 at the San Diego Convention Center in San Diego, California.
SLAS’s 5th annual international conference and exhibition gives attendees the chance to learn the latest and best practices for how to apply technology for life sciences research and development. Please note that the specific technologies featured here may not be at the show, but their manufacturers will be hand to answer your questions.
Analytical
r-Protein A Analytical Column
CIMac™
- This short bed, high performance monolithic column is primarily intended for fast, efficient, and reproducible qualitative and quantitative analyses of immunoglobulin G (IgG)
- Suitable for use with HPLC and UPLC systems • Quantification of immunoglobulin G is possible between 0.20 μg and 20 μg
- Small volume and short column length allow operation at high volumetric flow rates (up to 3 mL/min)
BIA Separations www.biaseparations.com
Gel Filtration/Aqueous Size-Exclusion Column
Yarra 1.8μm SEC-X150
- Designed for the separation of biomolecules on HPLC and UHPLC systems
- New Yarra surface chemistry, combined with bio-inert column hardware, reduces sample adsorption compared to other GFC/SEC columns currently on the market
- Provides improved recovery and more accurate quantitation of biomolecules
- Features a wide molecular weight range (1 – 450 kDa) and high efficiency
Phenomenex www.phenomenex.com
GC Column
Zebron™ ZB-5MSPLUS™
- Is a highly inert 5% phenyl-arylene phase GC column for challenging separations
- Designed with rigorous fused-silica deactivation and quality control processes
- Virtually eliminates active sites on the column’s surface that can negatively affect peak shapes for challenging compounds
- Produces better peak shapes without retention time shifts, and ultimately increases a lab’s productivity
Phenomenex www.phenomenex.com
Mass Spectrometer
6500+ Series
- Reaches ultra-low LOQs with trace sensitivity in both positive and negative ionization
- Detects more compounds in every injection with ultra-fast polarity switching
- Eliminates matrix interferences and improves selectivity with newly enhanced SelexION+ technology
- Improves confidence with QTRAP® technology and enhanced workflows for fast MS/MS screening via library searching, MRM3, and more
SCIEX sciex.com
UV-Vis Spectrophotometers
NanoDrop One & NanoDrop OneC
Booth 707
- Feature Thermo Scientific’s Acclaro Sample Intelligence technology
- Allows researchers to identify sample contaminants and obtain corrected concentration results
- Enables users to receive instant feedback about sample quality with on-demand technical support and guided troubleshooting
- Include embedded sensor and digital image analysis
- Sample-retention system measures 1-2 μL of sample in seconds without the need for cuvettes
Thermo Fisher Scientific www.thermoscientific.com
UHPLC/HPLC Columns
TSKgel® UP-SW3000
- Offer dual functionality for use in both UHPLC and HPLC systems
- Packed with 2 μm silica based particles and feature the same pore size as the well-established TSKgel G3000SWXL columns
- Available in 4.6 mm ID with 15 or 30 cm length
- The 15 cm column offers a shortened analysis time with improved efficiency while the 30 cm column delivers dramatically increased peak parameters
Tosoh Bioscience www.tosohbioscience.com
Basic Lab
Laboratory Convection Ovens
StableTemp™
- Offer scientists several options to enhance their processes
- Digital mechanical convection ovens quickly dry and heat samples and allow users to program and control through PC, if desired.
- Economy mechanical convection ovens deliver forced air convection with PID temperature control
- Economy gravity convection ovens provide gentle airflow for sterilization and drying
Cole-Parmer www.coleparmer.com
Permanent Magnet Motor
BGA22
- Can be used in laboratory robotics and handheld devices
- Measures just 22mm in diameter, 38mm in length, and weighs 0.065 kg
- Provides an excellent power-to-size / weight ratio performance, so is ideal for smaller medical devices or other similar handheld equipment
- Axial flux design has no cogging torque and therefore literally no vibration and quiet operation
Dunkermotoren www.dunkermotoren.de
Oxygen Flask Combustion Unit
- Based upon the internationally-recognized Schöniger flask method
- Designed for preparation of samples for single and mixed elemental analysis of chlorine, bromine, iodine, sulphur, and phosphorus content
- Provides a safe and repeatable tool for combusting samples prior to elemental analysis by ion chromatography or titration
- Unit remotely ignites samples inside a safety-interlocked chamber using focused infrared heat from two tungsten-halogen lamps
Exeter Analytical www.exeteranalytical.co.uk
Variable Speed Rotor Mill
PULVERISETTE 14 premium line
- Offers impact, shearing, and cutting comminution in one instrument
- Provides a fast sample throughput of up to 15 litres and more per hour, depending on the material and parameter settings
- A high-speed motor with ceramic bearings ensures a particularly high impact and rotor speed with an extra powerful 22,000 rpm
FRITSCH www.fritsch.de
PVC Acid Digestion Fume Hood
UniFlow
- Engineered specifically for extremely corrosive operations involving dissolution procedures for element analysis
- Features a totally chemical resistant hood construction with a welded one-piece PVC interior fume chamber including hood walls, ceiling, work surface, and rear drain trough
- Available in 48”, 60”, 72”, and 96” models, this series of fume hoods can be supplied with or without a built-in washdown system
HEMCO www.hemcocorp.com
Benchtop SEM
JSM-6000PLUS NeoScope
- Delivers fast, high magnification electron microscopy with more functionality than typical benchtop SEMs
- Now offers high sensitivity backscatter electron detection with a BSE detector manufactured by JEOL to detect contrast between areas of the sample with different chemical compositions
- Features simple design with touchscreen operation
- Ergonomic and easy-to-operate for a variety of applications
JEOL USA www.jeolusa.com
Potentiometric Titrator
COM-1700SC
- Can run multiple titrator stations that easily allow the end user to do different types of titrations including potentiometric, photometric, polarization, and conductometric titrations in parallel
- Users can add a model C-2012 automatic sample changer to increase sample throughput, automate pH calibration, and wash and prepare the electrodes for the next sample analysis
JM Science www.jmscience.com
Vacuum Pump Controller
VC 900
Booth 339
- Compatible with all vacuum sources and is easy to use
- Enables control of vacuum application
- Enhances reliability and precision
- Features a separate, independent control unit
KNF Neuberger www.knfusa.com
Entry Level Balance
ME-T
- Offers a reliable, high-performance weighing cell and a large, intuitive 4.5’’ color TFT screen
- Includes three interface connections for easy data handling
- Suited for day-to-day weighing in any lab or manufacturing environment where value for money has high priority
- Built-in applications and an intuitive user interface make the balance convenient and easy to use
METTLER TOLEDO www.mt.com
PID Controller
CNPT-DEMO
- Offers a fully integrated temperature control system suitable as a platform to investigate the use of closed loop (PID) and simple on/off temperature control in heating and cooling applications
- Suited for PID control theory education in universities and laboratories
- Easy to set up and use with intuitive “smart” menu flow, panel-mounted USB, and Ethernet connectivity
OMEGA www.omega.com
HPLC Pump
LU Class
- Consists of dual-headed, positive displacement piston pumps delivering accurate flow rates at extremely high pressures
- Available fluid path materials are stainless steel and titanium for standard and bio-compatible UHP chromatography applications
- Features a pressure capability of 18,000 psi, with a maximum flow of 5 mL/min
- Provides high flow accuracy over the entire pressure range
Scientific Systems ssihplc.com
Chilling/Heating Dry Bath
EchoTherm™ Model IC50
Booth 1247
- Peltier-driven, with exact sample temperature control
- Supplied with a temperature probe to insert directly into the sample or into the sample block
- Probe senses the sample temperature or sample block temperature directly and sends that information to the unit to drive and control the temperature exactly where set
- Displays and controls temperature to ±0.1°C Entry Level Balance
Torrey Pines Scientific www.torreypinesscientific.com
Informatics
HLA Analysis Software
Axiom™
- For automated, high-resolution human leukocyte antigen (HLA) typing from any genotyping dataset containing coverage of the extended major histocompatibility complex (MHC) region
- Software’s unique imputation algorithm enables 4-digit HLA typing from genome-wide association studies (GWAS), combining genotyping and high-resolution HLA typing into a single assay
- Provides simple, ‘push-button’ analysis to dramatically decrease researchers’ cost and workload
Affymetrix www.affymetrix.com
Spectroscopy Software
KnowItAll® 2015
- Features “Optimized Corrections” technology that performs a computationally complex set of corrections on all query and reference spectra in a search to find the optimal match between the query and each reference spectrum
- Also features two new software applications as well as the addition of spectra to its collection of Bio-Rad spectral databases that include KnowItAll QC Expert™, KnowItAll Deformulation Expert™, and new spectral data
Bio-Rad www.bio-rad.com
Flash Purification Interface
Isolera™ Assist
- Provides a structured guide for users resulting in consistent purification conditions and an intelligent way to select optimal cartridges based on crude sample mass and TLC data
- Available to all Isolera instruments
- Simplifies the setup procedure of a purification run, incorporating intelligence that guides the user to utilize the system in the most economical way
Biotage www.biotage.com
Control Driver for Mass Detector
Clarity
- The Microsaic 4000 MiD control module includes both digital control and data acquisition for the detector
- Includes MiDas compact interface module controls and allows users to perform detector calibration, maintenance, and service operations from the Device Monitor software window
- Provides seamless integration of Microsaic 4000 MiD with a wide range of HPLC systems that are already controlled by Clarity
DataApex www.dataapex.com
Spectroscopy Software Module
ProtectionPlus
Booth 1452
- Designed for the LabSpec 6 Spectroscopy Suite
- Fully integrated module seamlessly adds a layer of security and data integrity controls that enable compliant use of HORIBA Raman microscopes within regulated laboratory environments
- Offers a configurable module for system security administrators to put in place and enforce a wide range of security, user, and file policies
HORIBA www.horiba.com
Sample Management Software
FreezerPro® Cloud
Booth 852
- Available by subscription Software-as-a-Service
- Requires no installation or IT resources of any kind
- Offers the choice between public and private cloud, and includes many enterprise security features in all editions, such as SSL (secure socket layer) and 1,028 bit encryption, advanced persistent threat monitoring, virus scans, backups, and other premium services
RURO www.ruro.com
Lab Automation
Desktop X-ray Microtomograph
SKYSCAN™ 1275
Booth 1348
- Takes advantage of new X-ray source technology and efficient flat-panel detectors to reduce scan time to just a few minutes, without compromising image quality
- Push-button operation with a preselected sequence of actions, including scanning, reconstruction, and volume rendering means that even routine users can successfully obtain high-quality results
- Features an object size range up to 96mm in diameter and 120mm in length
Bruker www.bruker.com
Automated Positive Pressure Extraction & Evaporation Module
[MPE]2
Booth 807 (Hamilton Company)
- Cost-effective solution combines automated positive pressure SPE and evaporation in one device
- Integrates with all Hamilton automated liquid handling workstations
- Small footprint is scalable for increased throughput and walkaway time
- Patented design fits most filter/ collection plate combinations and includes pressure control up to 100 psi
Hamilton Robotics www.hamiltoncompany.com/slas
Microtube and Cryovial Storage Racks
RackWare HD138 and HD60
Booth 807 (Hamilton Company)
- These high-density SBS-footprint racks are designed for use with Hamilton’s BiOS, SAM and Verso sample management and storage systems
- Increase the storage capacity in a given space by increasing the number of tubes that can be placed in an SBS-footprint rack
- RackWare HD138 increases storage capacity in a comparable SBS footprint from 96 to 138 tubes, while HD60 increases the storage from 48 to 60 larger cryovials
Hamilton Robotics www.hamiltoncompany.com/slas
Life Science
Transplant Genotyping Array
Axiom®
- Designed to improve transplantation success and individualize donor/patient selection and treatment
- Comprises ~ 780,000 markers, including over 30,000 variants that may contribute to transplant rejection or other complications
- Meta-analyses may be conducted, combining data with other genotype databases such as the UK Biobank cohort, a collection of more than 500,000 volunteers genotyped using the Affymetrix UK Biobank Axiom Array
Affymetrix www.affymetrix.com
Next-Generation Sequencing Instrument
4200 TapeStation
Booth 1007
- This fully automated instrument enables scientists to rapidly analyze up to 96 DNA samples at a time
- Addresses the need for both higher throughput and higher quality in next-generation sequencing labs
- Allows end-to-end quality control of samples and libraries in any sequencing workflow, using any number of samples from one to 96, at a constant cost per sample
Agilent Technologies www.agilent.com
PCR Thermal Cycler
qTOWER³
Booth 517
- Patented fiber optic shuttle system with unique light source powered by 4 high-performance LEDs guarantees ideal excitation and detection of known fluorescent dyes up to the dark red
- System’s highly sensitive detection module can be equipped with up to 6 different color modules
- Silver block technology offers homogeneity of only ±0.1°C over the entire 96 well block
Analytik Jena www.analytik-jena.com
Thermal Cyclers
StableTemp
- Enable scientists to program PCR processes for easier operation
- Include two- and three-step PCR, RT-PCR, chill, and ligation program templates
- For greater flexibility, users can switch out thermal blocks to adapt to their changing lab needs
- Safety features include password protection of saved setting configurations and temperature cycle programs to prevent tampering and accidents
Cole-Parmer www.coleparmer.com
Kits for Bioprocess Analysis
Gyrolab™ CHO-HCP Kits 2-5 and Gyrolab Human IgG Titer Kits
- Four new Gyrolab CHO-HCP Kits 2-5 quantify host cell proteins (HCP) from Chinese hamster ovary (CHO) cells used in bioprocessing of biotherapeutics
- Gyrolab huIgG Kits, for determination of human IgG, come in two configurations, High Titer and Low Titer, have been developed to accurately and robustly quantify intact human IgG (IgG1, IgG2 and IgG4) during cell line development
Gyros www.gyros.com
CRISPR-Cas9 System
Alt-R™
- Improves genome editing potency thanks to research-optimized crRNAs (CRISPR RNA) and tracrRNAs (trans-activating crRNA)
- Features improved potency and safety
- Saves time by providing easy, ready-to-use RNA reagents that also reduce cell toxicity by avoiding activation of cellular innate immune responses
- Useful for very clean manipulations in cells, as it doesn’t leave a footprint that could cause undesired changes to the genome
Integrated DNA Technologies www.idtdna.com
Cell Culture Medium
BalanCD® Transfectory™ CHO
- For rapid, scalable production of recombinant proteins through transient transfection in CHO cells
- Chemically-defined and animal component free
- Has been specifically designed to support sustained, high growth with increased transfection efficiency that can yield gram-scale protein expression
- The ability to obtain gram-scale yields by transient transfection in CHO cells is a real step forward towards cutting costs and development time for biotherapeutic research
Irvine Scientific www.irvinesci.com
Supplies & Consumables
1.40ml Round Bottom Tubes
Booth 207
- Feature a working volume of 1.14ml
- Available in non-coded or alphanumeric coded versions
- Provide an affordable way to improve sample storage, handling, and logistic processes
- Can be purchased in bulk lots, refills or racked for 96-tube format use in the Comorack-96 or the fully automation-compatible
Roborack-96 Micronic www.micronic.com
96-Well Plates
Strata-X μElution
- Enable solid phase extraction from samples as small as 10μL, along with low elution volumes
- Conserve precious samples and reduce time requirements compared to traditional SPE plates, which require 200 μL elution volumes and a dry-down step to produce sufficient concentration
- Follow the same procedure as traditional 96-well SPE plates, however elution volumes are as low as 25μL, eliminating the need to perform a dry-down step
Phenomenex www.phenomenex.com
Single-Use Bags
Flexsafe® 3D Pre-designed Solutions
Booth 1223
- Meet all the functional and validation requirements of the biopharmaceutical industry
- Feature the appropriate components, functionalities, and quality controls that meet the specific requirements of each step in upstream and downstream processing and in final filling
- Available in a range of sizes from 50L to 1,000L and are made of robust, yet highly flexible, 400 μm thick co-extruded film structure
Sartorius Stedim Biotech www.sartorius-stedim.com