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Laboratory Technology

Small Molecules, Big Sensitivity

At the end of April, Agilent Technologies launched its 6545 Q-TOF mass spectrometry system, designed to provide added sensitivity for routine analyses.

Agilent Technologies

Recently launched Q-TOF more reliable and easier to use for trace-level analysis

According to Agilent, the advances in hardware and software included in this new midrange system make it both more reliable and easier to use for trace-level analysis of small-molecule compounds in applications such as food safety, environmental testing, forensic toxicology, and pharmaceuticals.

“The 6545 demonstrates Agilent’s commitment to increasing mass-spec sensitivity at every price point, delivering up to five times the sensitivity of previous instruments for small molecule analyses,” said Monty Benefiel, Agilent vice president and general manager of mass spectrometry products. “With Agilent mass-spec systems-along with our MassHunter software and compounds databases-any user can get exceptional quantitative and qualitative results.”

Engineered to be Agilent’s most reliable Q-TOF ever, the system features ion shaping optics, high-voltage power supplies, and longer-life parts to increase robustness. And, its new autotune software uses particle swarm technology to optimize the instrument for small-molecule analyses with the click of a button. In around 15 minutes, it optimizes the instrument to get up to five times more sensitivity for small molecule compounds, including low-intensity compounds.

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“The 6545 Q-TOF offers a substantial leap forward in sensitivity while maintaining all other features one expects from a high-end Q-TOF system,” said Dr. Koen Sandra, director of R&D at the Research Institute for Chromatography, which has sites in Belgium and France. Dr. Koen added the system allowed the institute to, “Elucidate impurities in pharmaceutical samples that we overlooked in the past.”

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