Tiny Robotic 'Hands' could Improve Cancer Diagnostics, Drug Delivery

Hydrogels such as poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAM-AAc) can be photopatterned to create a wide range of actuatable and self-folding microstructures. Mechanical motion is derived from the large and reversible swelling response of this cross-linked hydrogel in varying thermal or pH environments.American Chemical SocietyThe materials also could someday deliver therapeutic drugs to hard-to-reach places. The report appears in the American Chemical Society journal ACS Applied Materials & Interfaces.

David H. Gracias and colleagues note that many robotic tools require cords to provide power to generate their movements. But cords add to the bulk of robots, which limits the spaces they can access. To address this constraint, scientists have turned to hydrogels. These soft materials can swell in response to changes in temperature, acidity or light, providing energy to carry out tasks without being tethered to a power source. However, hydrogels are too floppy for some applications, so the group combined the hydrogels with a stiff biodegradable polymer, making the microhands strong enough to wrap around and remove cells. The team then sought a way to control where the grippers go once deployed in the body.

The researchers incorporated magnetic nanoparticles in the materials so they could guide the microhands with a magnetic probe. The team concluded that this added trait could help in the microassembly or microengineering of soft or biological parts, or give surgeons the ability to remotely direct where biopsies are taken. Also, Gracias says that the use of soft materials highlights the possibility of creating biodegradable, miniaturized surgical tools that can safely dissolve in the body (Watch a video of the grippers here).

The authors acknowledge funding from the National Science Foundation and the National Institutes of Health.