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Heparan Sulfate Products for COVID-19 Infection, Disease, & Therapeutics Research

Heparan sulfate is increasingly recognized as a key factor in infection by the SARS-CoV-2 virus, which is the cause of the current COVID-19 coronavirus pandemic


AMSBIO
Immunofluorescence for HS in the GFB (Glomerular filtration barrier) on human kidney sections using JM403 heparan sulfate antibody.
Image courtesy of Johan van der Vlag, Radboud University Medical Center, Nijmegen, The Netherlands

AMSBIO offers a wide range of heparan sulfate antibodies, enzymes, standards and ready-to-use heparanase activity assays for researchers seeking to better understand COVID-19 and thereby to combat the pandemic.

Heparan sulfate (HS) is increasingly recognized as a key factor in infection by the SARS-CoV-2 virus, which is the cause of the current COVID-19 coronavirus pandemic. Using HS antibodies from AMSBIO, researchers have demonstrated that heparanase enzyme contributes to the pathogenesis of COVID-19, with both heparanase activity and HS levels being elevated in plasma of COVID-19 patients. In addition, recent published data has shown that heparanase activity is further elevated in ICU patients on ventilators compared to less serious cases.

In particular, JM403 heparan sulfate antibody supplied by AMSBIO has been used in two novel assays developed and applied by Dr. Johan van der Vlag and colleagues at the Radboud University Medical Center, Nijmegen, Netherlands. They developed a JM403-based plasma heparanase activity assay, and a JM403-based HS competition ELISA to measure plasma HS levels.

Van der Vlag said, “The JM403 antibody from AMSBIO is a unique and powerful tool that is helping us develop new assays to measure plasma heparanase and HS levels in patients with COVID-19. A particular advantage of JM403 is that it is not reacting with heparins, which would have been a disturbing factor in our analyses, and which now allowed us to evaluate the effect of treating COVID-19 patients with low molecular weight heparins.”

For further information on heparan sulfate antibodies, enzymes, standards, and kits to assist research into SARS-CoV-2 infection, disease, and therapeutics, please visit https://www.amsbio.com/news/heparan-sulfate-in-covid-19-infection-disease-and-therapeutics/ or contact AMSBIO on +44-1235-828200 / +1-617-945-5033 / info@amsbio.com.  

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