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Horizon Discovery Expands Cell-Based CRISPR Screening Services

New arrayed B cell CRISPR knockout screening service strengthens support for development of therapeutics for diseases involving the immune system


CAMBRIDGE, UK — April 3, 2020 — Horizon Discovery Group plc (LSE: HZD), a global leader in the application of gene editing and gene modulation for cell line engineering, today (Apr. 3) announced the addition of an arrayed CRISPR knockout screening service for primary human B cells to its cell-based screening services.

Horizon now offers arrayed B cell CRISPR screening services.
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Primary human cells, which are cells that are freshly isolated from donors, are known to be difficult to study in the lab. However, working with these cells brings scientists one step closer to healthy or diseased micro-environments, enabling them to better understand disease etiology and therapeutic mechanisms, and thereby advance drug discovery and development programs. 

Horizon has already applied its gene editing and cell culture expertise to maintain the viability of primary human T cells to enable functional genomic screens and has been delivering data-rich information to customers working in drug discovery and development. The new B cell screening service, the first of its kind in the market, will enable researchers to identify genes that affect the function of B cells and examine how this impacts other immune cell types, particularly in infectious diseases, cancer, and auto-immune disorders, such as COVID-19, Burkitt’s lymphoma, and multiple sclerosis respectively.

“The interest in harnessing the immune system for effective therapies continues to grow, with the global cell therapy market predicted to reach $8.21bn by 2025*," said Terry Pizzie, CEO, Horizon Discovery. "Expanding our services to encompass screening of both primary T and B cells is another example of our commitment to apply decades of gene editing experience in support of drug discovery and development for the treatment of human disease.” 

For further information about Horizon’s cell-based screening services, please visit: https://horizondiscovery.com/navigation/screening/functional-genomic-screening 

*https://www.biopharma-reporter.com/Article/2019/03/04/Cell-therapy-market-to-triple-in-size-by-2025

Horizon Discovery Group