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Lysis and Hypotonic Sonication Buffers for ChIP Assays

The Porvair Sciences Chromatrap® buffer chemistries are optimized for sonication and enzymatic shearing

Computer image of a cell being sheared

For enzymatic shearing from fixed cells or tissue—both these detergent-based buffers are ideal for effective fragmentation of nuclear material.

Porvair Sciences

Offering complete disruption of cytoplasmic and nuclear membranes, Porvair Sciences Chromatrap® buffer chemistries are optimized for sonication and enzymatic shearing.

The success of a ChIP assay is highly dependent on the quality of chromatin prepared. Chromatrap® lysis and hypotonic buffers are high performance reagents you can trust in this critical first step in isolating chromatin from your sample. For enzymatic shearing from fixed cells or tissue—both these detergent-based buffers are ideal for effective fragmentation of nuclear material.

For the disruption of cell membranes, Porvair Sciences optimized Chromatrap® hypotonic buffer composition ensures effective lysis of cell membranes to aid in the release of nuclei material from a wide range of varied species.

Formulated for difficult to lyse cell types and tissues, Porvair Sciences optimized Chromatrap® lysis buffer is proven to enable researchers to better explore and understand the underlying processes and mechanisms that drive biological organisms.