Product News

The Olympus scanR High-Content Screening Station Rapidly Acquires Quantitative Data from Cell-Based Assays

Self-learning microscopy opens new horizons in high-content analysis and advances phenotypic screening

Olympus Corporation

WALTHAM, MA December 5, 2019 — Olympus announces the US launch of the scanR high-content screening (HCS) station, a cell imaging solution that utilizes artificial intelligence (AI) to enable next-generation biological research. It combines the modularity and flexibility of a microscope-based setup with the automation, speed, throughput, and reproducibility of an HCS station. 

AI Meets High-Content Screening

Olympus ScanR Modular High-Content Screening Station for Life SciencesOlympus ScanR modular high-content screening station for life sciences.Credit: OlympusThe Olympus scanR HCS station uses the power of AI to carry out groundbreaking analyses of cells that, until recently, seemed impossible to do. Olympus’ self-learning microscopy technology reduces photobleaching and improves acquisition speed, measurement sensitivity, and accuracy, facilitating longer observations with reduced influence on cell viability. 

The Power of Deep Learning

The system acquires pairs of images that are processed by the software to generate an image analysis model. Olympus’ optimized deep-learning technology, which is based on a dedicated convolutional neural network architecture, provides powerful and flexible learned analysis protocols. No human data annotations are required, which allows large numbers of examples to be used, enabling the potential of the deep-learning technology to be fully exploited. 

Self-Learning Microscopy

Self-Learning Microscopy from OlympusSelf-Learning Microscopy: AI prediction of nuclei positions (blue), green fluorescent protein (GFP) histone 2B labels showing nuclei (green), and raw brightfield transmission image (gray).Credit: OlympusAfter a one-time training phase, scanR AI enables the system to automatically analyze new data by incorporating the learned analysis protocol into its assay-based workflow. Because the user has full control in designing the training experiment and many challenging analysis conditions can be covered during the training phase, the accuracy and robustness of the analysis results are improved. 

Robust, Fast, and Automated Image Acquisition and Analysis

The scanR system performs fully automated image acquisition and analysis of multiwell plates, slides, and custom-built arrays. Throughout the automated image acquisition, the scanR system maintains the focus plane using a combination of software algorithms and hardware, including TruFocus Z-drift compensation. Images are automatically analyzed during acquisition to minimize analysis time, and all units are precisely synchronized by a real-time controller to maximize the acquisition speed. 

Simple Workflow and Fast Setup to Ease Research

The scanR HCS station combines these benefits with a user-friendly workflow that requires less human interaction, even during the AI training stage. The responsive interface contributes to intuitive, straightforward analysis. This makes it easy for life science and pharmaceutical researchers to harness the power of HCS data while benefitting from a fast, simple setup. 

For more information, please visit olympus-lifescience.com/microscopes/inverted/scanr/