Strict adherence to the 500 mL extraction volume for EPA 1633 is the standard defense against sample heterogeneity and auditor scrutiny. But processing half a liter of aqueous sample per test backs up the prep manifold and passes a matrix burden downstream to the mass spectrometer.
This resource details workflow modifications across three standalone application notes. The data covers scaled-down extraction volumes and automated sample prep alongside an extended LC-MS/MS reliability study. Each note documents conditions and quantitative results, including 17,500 injections on complex samples, as a reference point for evaluating whether a protocol change holds under your testing demands.
Download the eBook to:
- Examine the volume reduction thresholds the 50 mL extraction protocol tests against method detection limits and recovery criteria
- Trace the SPE automation modifications that reduce manual handling time and cartridge fouling risk across ground, surface, influent, and effluent matrices
- Assess continuous injection sequence data showing baseline stability and quantitative accuracy under sustained high-matrix load on the Xevo TQ Absolute
