Freeze dryers use a combination of refrigeration and vacuum pressure to meet the lyophilization needs of a variety of research and manufacturing environments. They are commonly used for culture storage, food and pharmaceutical processing, and material stabilization. With a wide variety of options available, there is much to consider when purchasing a new freeze dryer.
Top 5 Questions You Should Ask When Buying a Freeze Dryer
- What solvents are you using? A temperature differential between the sample’s eutectic temperature and collector temperature of 15–20 degrees is required. If solvents such as acetonitrile are used, a cascade freeze dryer is required.
- How much sample in liters will you run? When choosing a freeze dryer, vendors recommend loading 1/2 of the listed capacity. For example, a 6L freeze dryer will hold 3L during the run.
- Do you want to freeze dry in flasks, tubes, or bulk? Many drying accessories are available. On a manifold or drying chamber, flasks can be placed on each port. Test tubes and serum vials can be placed inside of the flasks for multiple samples per container. If samples are bulk, a tray dryer would be a good choice.
- Do you need to stopper under vacuum? Accessories can allow you to stopper under vacuum or nitrogen without using compressed gas.
- Is this a shared freeze dryer? A hybrid pump is recommended to prevent damage to the pump.
Types of freeze dryers used by survey respondents:
|Dry Ice Benchtop||14%|
Freeze dryer applications as reported by survey respondents:
|Material stabilization and/or storage||49%|
|Starters and cultures||16%|
Nearly 42% of respondents are engaged in purchasing a new freeze dryer. The reasons for these purchases are as follows:
|Replacement of an aging system|
|Addition to existing systems|
|Setting up a new lab|
|First time purchase|
Top 10 features/factors respondents look for when purchasing a freeze dryer:
|Ease of use||81%|
|Product performance for intended application||74%|
|Reliability under high performance||67%|
|Low maintenance/operating costs||67%|
|Service and support||63%|
|Accurate vacuum control||58%|
|Ease of installation||52%|
|Vacuum or filtered stoppering||49%|