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tag neurodegenerative diseases page 4

Troubleshooting Chromatography Systems

by Rachel Muenz
Josephine Ferreon is an assistant professor in the Department of Pharmacology, Baylor College of Medicine in Houston, Texas. Her structural biology group characterizes various intrinsically disordered proteins (IDPs), important in stem cell biology and neurodegenerative diseases, using standard and state-of-the-art biochemical/biophysical techniques such as NMR and single molecule fluorescence spectroscopy.

How Measuring Cell Metabolism Works

by Seahorse Bioscience
Problem: At the crossroads of understanding cell physiology, disease pathology and etiology lies cell metabolism, encompassing the cellular set of life-sustaining chemical transformations. Dysregulation of cell metabolism is now known to be a common component of cancer, immunology, obesity, diabetes, and neurodegenerative disease. This is because mitochondrial respiration and glycolysis are the major sources of life-sustaining and biosynthetic processes for the cell, specifically energy in the form of ATP (adenosine triphosphate) and macromolecules such as membranes, nucleotides, transporters, organelles, etc. Metabolic pathways are increasingly considered as potential therapeutic targets. Therefore, the ability to measure and understand cellular bioenergetics can provide valuable insight into disease and contribute to the potential identification of drug discovery targets. 

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