Live Webcast: Thursday, November 3, 2011 at 8:00 a.m. PST, 11:00 a.m. EST, 15:00 GMT
Register Free at http://chromatographyonline.com/metabolomics
The study of small-molecule metabolites in biological fluids and tissue has become increasingly popular. However, scientists investigating the presence and flux of these metabolites face formidable challenges. By their very nature, both matrices and analytes of interest are highly complex. HPLC (and UHPLC) coupled to mass spectrometry has become the laboratories’ analytical workhorse in metabolomic studies, but doesn’t provide the complete picture. More than one analytical tool is needed to help provide the missing data. Two techniques often overlooked in this field are ion-exchange chromatography (IC) and liquid chromatography coupled to electrochemical detection (LC-EC). This webinar demonstrates how each technique can contribute pieces of the puzzle to better understand the metabolome. Data will be presented demonstrating the useful information that can be obtained in metabolomic studies using IC, IC-MS and LC-EC.
Who Should Attend:
- Life science researchers investigating targeted and untargeted metabolomics
- Pharmaceutical scientists involved in disease discovery
- Pharmaceutical scientists involved in drug discovery and early drug development
Key Learning Objectives:
- Learn about multiple analytical techniques to characterize complex biological systems
- Learn about Ion-exchange chromatography offering an orthogonal set of analytical information
- Learn about how electrochemical detection, when coupled to mass spectrometry, provides high selectivity and high sensitivity analysis
Karl Burgess, Ph. D.
Head of Metabolomics,
Scottish Metabolomics Facility,
Paul Gamache, M.S.
Director, Life Science Research,
HPLC Research & Development,
Thermo Fisher Scientific