Incubator contamination is inherently a potential for all incubator manufacturers. Typical laboratories have thousands of airborne contaminants that may enter a tissue cell culture incubator during a door opening, and enter the perfect growth environment to survive and reproduce. Elimination of these airborne contaminants as they enter the incubator would be the best solution, but not feasible given today's technology. However, other potential solutions to the contamination problem are available today. High Efficiency Particulate Air (HEPA) filters are available to remove airborne contaminants thus providing a solution to the problem.

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