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Automating Production of Compound Libraries

Flow protocol accelerates reaction optimization


A new application note describes an efficient continuous flow synthesis protocol to create a new library of pyrazoles developed by chemists at GalChimia on a FlowSyn™ continuous flow reactor system. The aim of the described work was to develop a new continuous flow protocol to replace the traditional 2-step synthesis and to examine the scope of the new methodology.

The authors of the application note demonstrate that by using the FlowSyn system, a range of conditions could be quickly evaluated under flow-through conditions, thereby facilitating rapid reaction optimization. In addition, by using the continuous flow chemistry protocol, useful quantities of a wide range of pyrazoles could be prepared in less than one hour each.

Download the application note to learn more about the application of flow chemistry to the production of compound libraries, courtesy of Uniqsis.