Alex Wong (right) and Farnoud KazemzadehAlex Wong (right) and Farnoud Kazemzadeh use artificial intelligence to examine medical images.Photo courtesy of the University of Waterloo A recent advancement in microscope imaging technology at the University of Waterloo could soon make diagnosing disease more accessible and affordable.

The advancement, developed by Waterloo researchers Farnoud Kazemzadeh and Alexander Wong, has led to a new form of spectral light-fusion microscope for capturing lightfield images in full-color. Full-color images are required in pathology as it enables the microscope user to analyze the behavior and interactions of different organisms at a scale much larger than traditional microscopes.

Pathology is a medical specialty that focuses on the diagnosis of disease based on laboratory analysis of bodily fluids and tissues.

The several-hundred-dollar microscope has no lens, and uses artificial intelligence and mathematical models of light to develop 3D images at a large scale. It’s a process that currently requires a technician to “stitch” together multiple images from traditional microscope images to get the same effect, and requires a machine that costs several hundred thousand dollars.

Wong and Kazemzadeh's spectral light-fusion microscopeWong and Kazemzadeh's spectral light-fusion microscope.Photo courtesy of the University of Waterloo“In medicine, we know that pathology is the gold standard in helping to analyze and diagnose patients, but that standard is difficult to come by in areas that can’t afford it,” said Wong, an associate professor of Engineering at Waterloo and Canada Research Chair in Medical Imaging. “This technology has the potential to make pathology labs more affordable for communities who currently don’t have access to conventional equipment.”

The current spectral light-fusion microscope represents the second-generation of technology that he patented last year with Kazemzadeh.

The microscope captures light fields and allows for 3D images that are approximately 100-times larger than the 2D images captured by more traditional microscopes.

“Currently, the technology required to operate a pathology lab is quite expensive and is largely restricted to places such as Europe and North America, which can afford them,” said Kazemzadeh, an adjunct professor of Systems Design Engineering at Waterloo. “It would be interesting to see what a more affordable, mobile pathology lab could achieve.”

Details of the first-generation microscope invented by Kazemzadeh and Wong were published last year in Nature Scientific Reports.