A Comprehensive Guide to Accelerating Cell Line Development Produced by Introduction Cell Line Development (CLD) is an essential step in the journey to groundbreaking therapeutic products. The careful selection of cell lines significantly shapes the later phases of development, ensuring the quality and efficacy of the end products. A finely tuned CLD process ensures the consistent generation of pre-qualified, high yielding cell lines, enhancing manufacturing efficiency by reducing waste and operational costs while accelerating time to market. While traditional CLD has historically grappled with inefficiency and limited capacity, the emergence of innovative technologies has reshaped the landscape. These innovations provide early detection of unsuitable cell lines, streamlining selection processes and reducing overhead. Automation optimizes infrastructure utilization and drives improvements in quality, consistency, scalability and throughput, paving the way for seamless workflows and improved resource allocation. New data management approaches facilitate regulatory compliance, strengthened data integrity, accelerated data capture and reporting and enhanced knowledge sharing. While the prospect of exploring and accessing these advancements may seem daunting, the Life Sciences companies of Danaher—Abcam, Beckman Coulter Life Sciences, Genedata, IDBS, Leica Microsystems, Molecular Devices, Phenomenex and SCIEX—enable consolidated access to a comprehensive range of expertise. This diversified portfolio presents an integrated approach, yielding significant benefits at every juncture. By partnering with the Life Sciences companies of Danaher, laboratories stand to accelerate the implementation of solutions, harnessing the collective expertise and cutting-edge technologies of these companies. Danaher is dedicated to empowering researchers with tailored solutions that align with their distinct requirements, unlocking the full potential for acceleration and transforming CLD during drug development. 2 CLD Workflow Vector Construct & Sequence Verification Stable Transfection & Selection Mini-pool Screening Single Cell Cloning Clone Recovery & Selection Stability Study Sequencing Verification CQA Verification Scale-up Selection Sequencing Verification CQA Verification Master Cell Bank GMP Production Cell Banking Cell Banking Cell Banking Need to achieve higher expression levels – screen high-producer cell lines FASTER Getting CQA insights FASTER STABILITY, IMMUNOGENICITY, and SCALABILITY assessment: eliminating unstable cell lines that are not scalable early on Increased demand for higher PRODUCTIVITY due to increased # of projects and complex antibody molecules while number of FTEs remain constant Significant amount of time spend on MANUAL DATA PROCESSING using spreadsheets Need for TRACKING and TRACEABILITY (data, lot numbers, SOPs, processes, etc) Challenges Beckman Coulter Life Sciences Valita Titer IgG Quantification assay Beckman Coulter Life Sciences Valita Aggregation Pure assay SCIEX Intabio ZT System SCIEX Intabio ZT System Analytical Solutions Beckman Coulter Life Sciences Total Lab Automation Genedata Bioprocess - Structured Knowledge Management System for E2E Bioprocess Development Genedata Selector Software - Targeted Locus Amplification (TLA), Genome Stability, Variant Detection, Sequence Verification, Contamination Genedata Expressionist SoftwareMass spectrometry data analysis Genedata Selector Software Genedata Expressionist Software Molecular Devices ClonePix 2 Mammalian Colony Picker Beckman Coulter Life Sciences Biomek i-Series Automated Liquid Handler Beckman Coulter Life Sciences Biomek i-Series Automated Liquid Handler Molecular Devices CloneSelect Imager Automation IDBS Polar delivers the tools Cell Line Development scientists need to capture product and process data throughout their cell line development and seamlessly integrate process and analytical data, to deliver trustworthy, complete AI/ML ready data and achieve greater insight Data Solutions Beckman Coulter Life Sciences Valita Titer IgG Quantification assay Beckman Coulter Life Sciences Valita Aggregation Pure assay 3 Analytics Early integration of advanced analytics significantly improves the precision and efficiency of selecting optimal cell lines. Accurately verifying attributes like titer earlier in CLD can accelerate the developmental timeline and reduce costs. Rapid IgG Quantification Rapid and High-Throughput IgG Quantification in Cell Culture Supernatant using Beckman Coulter Life Sciences Valita Titer Assays for IgG Quantification CLD researchers have grappled with the time-consuming and labor-intensive process of identifying high-producing cell lines and selecting the best candidate for further development of therapeutic antibodies. Production efficiency hinges on the ability to select cell lines that exhibit robust antibody expression. IgG quantification has traditionally been a labor-intensive process, often taking hours or even days to produce results. This can add complexity and cost to the development timeline when processing hundreds or thousands of clones to create a commercially viable cell line. Laboratories require a faster and more efficient approach to IgG quantification. We see a way to accelerate CLD process by identifying high producers in<15minutes. CLD Workflow Vector Construct & Sequence Verification Stable Transfection & Selection Mini-pool Screening Single Cell Cloning Clone Recovery & Selection Stability Study Sequencing Verification CQA Verification Scale-up Selection Sequencing Verification CQA Verification Master Cell Bank GMP Production Cell Banking Cell Banking Cell Banking Innovative and automation-friendly high-throughput tools like the Beckman Coulter Life Sciences Valita Titer Assays for IgG Quantification offer a solution. With this technology, the time required to assess titer is reduced to just minutes. The process involves a simple “add, mix and read” workflow. This assay’s simplicity represents a significant advancement in IgG quantification, allowing for the rapid identification of high-producing cell lines. In this poster, you will discover: • Methods for streamlining IgG quantification during cell line development • The principle behind the Valita Titer IgG Quantification assay • A comparison of Valita Titer IgG Quantification assay with industry-standard IgG quantification techniques Download the poster Beckman Coulter Life Sciences Valita Titer IgG Quantification assay Beckman Coulter Life Sciences Valita Aggregation Pure assay Analytical Solutions Beckman Coulter Life Sciences Valita Titer IgG Quantification assay Beckman Coulter Life Sciences Valita Aggregation Pure assay 5 CLD Workflow Vector Construct & Sequence Verification Stable Transfection & Selection Mini-pool Screening Single Cell Cloning Clone Recovery & Selection Stability Study Sequencing Verification CQA Verification Scale-up Selection Sequencing Verification CQA Verification Master Cell Bank GMP Production Cell Banking Cell Banking Cell Banking Fast-Track Protein Characterization and Quantification Direct and Rapid Multi-Attribute Monitoring of Intact Monoclonal Antibodies by icIEF-UV/MS Monoclonal antibodies (mAbs) are a crucial class of biotherapeutics due to their high specificity, efficacy and adaptability for treating various diseases. Enzymatic cleavage and chemical post-translational modifications (PTMs) during manufacturing introduce charge variants, which can have a considerable influence on the properties of mAbs both in vitro and in vivo. Their impact on critical factors such as antibody binding, tissue penetration and distribution and antibody pharmacokinetics make characterizing charge heterogeneity essential for critical quality attribute (CQA) assessment. CQAs encompass a spectrum of properties that must adhere to predefined limits or ranges to guarantee that the final therapeutic product meets the required quality standards, ensuring safety, efficacy and potency. Imaged capillary isoelectric focusing (icIEF) offers a high-resolution separation of protein charge variants, including those with similar isoelectric points. This functionality has made it popular for monitoring CQAs and product quality attributes (PQA). Until now, identifying and characterizing PTMs from charge variants typically required multiple advanced analytical techniques and consumed significant amounts of time. The Intabio ZT system facilitates direct coupling of icIEF charge variant analysis, UV quantitation and high-resolution mass spectrometry (MS), enabling researchers to confidently identify intact proteins. icIEF-UV/MS facilitates a streamlined workflow, reducing the time to results from weeks to approximately one hour for routine samples, compared to ion exchange chromatography with fraction collection. SCIEX Intabio ZT System SCIEX Intabio ZT System Analytical Solutions 6 CLD Workflow Vector Construct & Sequence Verification Stable Transfection & Selection Mini-pool Screening Single Cell Cloning Clone Recovery & Selection Stability Study Sequencing Verification CQA Verification Scale-up Selection Sequencing Verification CQA Verification Master Cell Bank GMP Production Cell Banking Cell Banking Cell Banking Read the full application note to explore: • The integration of imaged capillary isoelectric focusing with mass spectrometry and UV quantitation • Strategies for significantly reducing the time to results • Advanced techniques for charge variant analysis of monoclonal antibodies • Approaches for identifying and characterizing different post-translational modifications from charge variant peaks Download the application note SCIEX Intabio ZT System SCIEX Intabio ZT System Analytical Solutions 7 Automation We see a way to accelerate the CLD clone picking process by 8Xand reduce waste by 50%. CLD Workflow Vector Construct & Sequence Verification Stable Transfection & Selection Mini-pool Screening Single Cell Cloning Clone Recovery & Selection Stability Study Sequencing Verification CQA Verification Scale-up Selection Sequencing Verification CQA Verification Master Cell Bank GMP Production Cell Banking Cell Banking Cell Banking The push to accelerate the CLD process emphasizes the need for robust processes and advanced automation. This can significantly bolster efficiency, consistency, accuracy and productivity. Automation is a powerful solution to bypass resource limits and variability from manual input and tasks. Making automation a cornerstone of the CLD process enables researchers to unlock new possibilities, accelerating the path to groundbreaking life-saving treatments. Automating Colony Picking Workflows Mammalian cell line development automation with Molecular Devices Historically, clone selection within CLD has presented a formidable challenge. Traditional manual methods are synonymous with low throughput, characterized by their time-consuming, labor-intensive nature and heightened susceptibility to errors. In stark contrast, automated clone selection has ushered in an era of precise, nuanced high-throughput methods, with a special emphasis on isolating high-value clones. Compared to conventional manual techniques, automated systems can rapidly and efficiently manage extensive numbers of clones. The commitment to ensuring monoclonality and a steadfast focus on accuracy and consistency becomes critical for adhering to regulatory standards and achieving product uniformity. Automated clone selection not only advances the efficiency of the CLD process but also reinforces the integrity and reliability of the resulting product. Molecular Devices CloneSelect Imager Automation Molecular Devices ClonePix 2 Mammalian Colony Picker 9 CLD Workflow Vector Construct & Sequence Verification Stable Transfection & Selection Mini-pool Screening Single Cell Cloning Clone Recovery & Selection Stability Study Sequencing Verification CQA Verification Scale-up Selection Sequencing Verification CQA Verification Master Cell Bank GMP Production Cell Banking Cell Banking Cell Banking Download the eBook Read the full eBook to learn how to: • Shorten workflow timelines for CLD • Scale up processes for screening • Optimize seeding densities • Assess additional considerations for mammalian colony screening Molecular Devices CloneSelect Imager Molecular Devices ClonePix 2 Mammalian Colony Picker Automation 10 CLD Workflow Vector Construct & Sequence Verification Stable Transfection & Selection Mini-pool Screening Single Cell Cloning Clone Recovery & Selection Stability Study Sequencing Verification CQA Verification Scale-up Selection Sequencing Verification CQA Verification Master Cell Bank GMP Production Cell Banking Cell Banking Cell Banking Automating Cell Line Development Integrated workstations play a crucial role in automating a significant part of the CLD process, addressing resource bottlenecks and ensuring consistency and accuracy To meet the demand for high-throughput screening and prevent contamination, integrated workstations equipped with liquid handlers, incubators, centrifuges, colony pickers and cell analyzers can fully automate cell culture and sample preparation, thereby improving efficiency and maintaining sterility. By reducing the need for human intervention, these systems enable faster progression from initial cell transfection to final clone selection. The resulting efficiency gains and improved throughput are essential for the development of therapeutic biologics. The application note linked below demonstrates the full automation of clone establishment and screening using the Beckman Coulter Life Sciences Biomek i7 Workstation with multiple integrations. Read the full application note to discover how to: • Minimize sample contamination risk • Improve semi-solid media pipetting consistency • Automate confluence and titer measurements to drive hit picking • Reduce hands-on time moving labware • Automate cell counting for in-process calculations of transfer volumes Read the application note Beckman Coulter Life Sciences Total Lab Automation Beckman Coulter Life Sciences Biomek i-Series Automated Liquid Handler Beckman Coulter Life Sciences Biomek i-Series Automated Liquid Handler Automation 11 Data Modern CLD labs generate a large amount of data and require secure data systems and practices to ensure compliance, accuracy, collaboration and knowledge sharing while minimizing potential errors. CLD labs have complex data capture, handling and reporting needs, making data handling particularly important. Errors or inconsistencies in data capture and handling can lead to unreliable conclusions, risking the validity of scientific findings and regulatory compliance. Labs must establish strict protocols and technologies to guarantee the accuracy and traceability of data throughout the CLD process. Efficient searchability, shareability and proper data archiving are also critical across labs. Teams must be able to easily access and share relevant data for analysis. This requires systems with strong connectivity and information exchange. Additionally, data archiving must be done carefully to ensure that valuable information is preserved for future reference and meets regulatory requirements. Analyzing and interpreting data to gain insights often presents a challenge. As labs streamline their processes and improve efficiency, adopting enhanced data capture and automation technologies becomes crucial. Automated data capture systems significantly reduce the potential for human errors and increase accuracy and productivity. By utilizing powerful data analytics solutions, researchers can gain deeper insights, identify trends and make informed decisions. CLD Workflow Vector Construct & Sequence Verification Stable Transfection & Selection Mini-pool Screening Single Cell Cloning Clone Recovery & Selection Stability Study Sequencing Verification CQA Verification Scale-up Selection Sequencing Verification CQA Verification Master Cell Bank GMP Production Cell Banking Cell Banking Cell Banking Accelerate Data Capture, Analysis and Reporting Lifecycle data solutions save time, improve quality and ensure regulatory compliance Generally, new biologics take a decade or more to bring to market and come with a hefty cost. There is an urgent need to increase efficiency and cost-effectiveness to address this. Organizations still spend close to 30% of their time handling and managing their data, and poor data quality can cost organizations upwards of $12 million a year, making this a high-impact target for reform. The solution involves an innovative software platform that creates a continuous and robust data foundation throughout the entire CLD process and seamlessly connects early-stage development with later phases. IDBS Polar is a powerful cloud-based software platform for biopharma professionals seeking to accelerate their time to market. IDBS Polar collects, manages, analyzes and allows the sharing of product and process data enabling actionable insights and regulatory compliance throughout the drug development process. By capturing contextualized process and product data at the point of execution, it ensures data integrity is maintained and a hierarchy of experiments and cell cultures are generated. Access to timely data insights leads to better study design, enhancing development efforts and reducing the number of required experiments. IDBS Polar enables faster insights, speeding up time to market. Cell line development Many CLD labs still perform manual transcription due either to data silos driven by legacy equipment and systems or paper-based data capture. Fully connecting systems and driving consistent, standardized data capture processes and automated analytics remove the burden and risks of manual transcription. Combining the improved accuracy with complete transparency IDBS Polar delivers the tools Cell Line Development scientists need to capture product and process data throughout their cell line development and seamlessly integrate process and analytical data, to deliver trustworthy, complete AI/ML ready data and achieve greater insight Data Solutions 13 CLD Workflow Vector Construct & Sequence Verification Stable Transfection & Selection Mini-pool Screening Single Cell Cloning Clone Recovery & Selection Stability Study Sequencing Verification CQA Verification Scale-up Selection Sequencing Verification CQA Verification Master Cell Bank GMP Production Cell Banking Cell Banking Cell Banking and traceability of sample data and audit trails ensures data integrity. It also facilitates collaboration with effective data sharing and intact, contextualized knowledge transfer between teams. Together, these features significantly reduce the time needed to develop optimized cell lines, deliver reports and submit regulatory filings. For cell line development, data capture and reporting involve keeping track of passage numbers and maintaining traceability from transfection to clone selection, which can be tedious and time-consuming. IDBS Polar integrates process and analytical data, improves documentation and reporting and maintains cell line genealogy. The history and performance of a clone can be quickly uncovered at any point during cell line development. The benefits of a single, comprehensive platform are realized from day one with improved quality and reproducibility. Samples, materials and equipment can be registered and utilized from an integrated inventory management system. Researchers can define recipes, procedures and parameters of methods and assays, providing easy reference for repeatable and effortless execution, where documentation ensures quality while retaining flexibility. IDBS Polar offers capabilities across workflows and the platform from identifying and genealogically linking cell cultures, to automating experimental calculations and cloning plate layouts, to charting and graphically representing ranked clone measurements. During cloning for the limiting dilution method, for example, it will generate a plate layout with unique well-references to identify clones and capture result values to rank clones for faster progress. In clone screening, IDBS Polar will graphically represent result measurements for each clone across time points. It will also record the process of freezing cultures and their thawing, reviving and pooling to begin the subculturing process ensuring procedures are accurately documented and traced to support the subculturing process. Polar can incorporate instrument and system integrations across CLD to improve process documentation, generate trustworthy data, enrich analysis with context and provide turnkey analytics and visualization. Selecting the best-performing host cell line and the lead clone has a large impact on the quality of the protein of interest and requires analysis of data from multiple sources. With IDBS Polar CLD labs can capture and analyze data in multiple formats and from a variety of experiment and instrument sources. Pre-built and custom applications within IDBS Polar allow CLD teams to create and execute studies and perform statistical analysis. This retrospective analysis enables the identification and investigation of relationships and correlations in the data. It also allows for the identification of potential causes of process variability and the utilization of assimilated data to predict future behaviors. Adapting this technology early and throughout the entire drug development process, and curating all data in a single platform, maintains data integrity, increases data continuity and consistency and supports the handover of processes and materials to subsequent process development, scale-up and tech transfer activities. IDBS Polar delivers the tools Cell Line Development scientists need to capture product and process data throughout their cell line development and seamlessly integrate process and analytical data, to deliver trustworthy, complete AI/ML ready data and achieve greater insight Data Solutions 14 CLD Workflow Vector Construct & Sequence Verification Stable Transfection & Selection Mini-pool Screening Single Cell Cloning Clone Recovery & Selection Stability Study Sequencing Verification CQA Verification Scale-up Selection Sequencing Verification CQA Verification Master Cell Bank GMP Production Cell Banking Cell Banking Cell Banking Cell Line Development Polar can be configured to meet the exact nature of CLD work, with expertise including, but not limited to: ▶ Transfection ▶ Cloning ▶ Clone Screening Analytical To seamlessly connect process and analytical data within a single platform, Analytical experiments can be executed and bi-directionally linked back to parent unit operations. Capabilities include: ▶ Plate Based Assays (e.g., ELISA) ▶ Gel Based Assays (e.g., CE-SDS) ▶ HPLC ▶ DNA Extraction Insights Polar’s analytics engine enables organizations to leverage multimodal data with advanced analytics (AI/ML) capabilities to analyze scientific processes and workflows not only for retrospective analysis but also for predictive analytics to ensure processes remain in control. Pre-built applications include: ▶ Cell Line Genealogy ▶ Bioreactor Comparison ▶ Design of Experiments (Design & Analysis) ▶ Multivariate Analysis Process Development Following the CLD workflow, Polar also provides the framework to capture Process Development activities, including: ▶ Cell Expansion ▶ Bioreactor ▶ Harvest ▶ Chromatography Full traceability for the development of optimized cell lines Streamlined support for in-process testing and analytical method development Reduction in the time and data integrity risks to assimilate data and conduct analysis Increased productivity, scalability and yield of high-performing cell lines ▶ Cell Freezing ▶ Cell Thaw & Revival ▶ Recipe & Reagent Management ▶ qPCR ▶ UV-VIS ▶ icIEF ▶ Free Thiol ▶ Time Series Comparison ▶ Inventory Monitoring ▶ Equipment Management ▶ Operational Analytics ▶ Filtration ▶ TFF ▶ Column Packing & Unpacking IDBS Polar delivers the tools Cell Line Development scientists need to capture product and process data throughout their cell line development and seamlessly integrate process and analytical data, to deliver trustworthy, complete AI/ML ready data and achieve greater insight Data Solutions Save 7000 hours each year on experiment execution. Save $1.1 million after one year. 15 CLD Workflow Vector Construct & Sequence Verification Stable Transfection & Selection Mini-pool Screening Single Cell Cloning Clone Recovery & Selection Stability Study Sequencing Verification CQA Verification Scale-up Selection Sequencing Verification CQA Verification Master Cell Bank GMP Production Cell Banking Cell Banking Cell Banking Accelerating regulatory filings and approvals The most effective and efficient biopharmaceutical compliance strategies start at the beginning. Regulatory filings frequently involve delays from multiple sources, including paperwork, error identification, rework and review. A meticulous organization with robust, unbroken data streams can streamline submissions and accelerate approvals. End-to-end digitalization with a compliance-ready system facilitates data verification and offers real-time compliance monitoring. IDBS Polar comes equipped with the features required for GxP validation and compliance with FDA 21 CFR Part 11 and EudraLex V4 Annex 11, such as digital signatures, secure audit records and a digital chain of custody. Addressing the many demands on data in modern labs requires the integration of advanced technologies and well-defined digital protocols. By embracing automation and streamlined data management through biopharma lifecycle management platforms, labs can optimize their operations, achieve compliance with regulatory standards and drive scientific progress, ultimately accelerating groundbreaking therapeutics. IDBS Polar delivers the tools Cell Line Development scientists need to capture product and process data throughout their cell line development and seamlessly integrate process and analytical data, to deliver trustworthy, complete AI/ML ready data and achieve greater insight Data Solutions 16 CLD Workflow Vector Construct & Sequence Verification Stable Transfection & Selection Mini-pool Screening Single Cell Cloning Clone Recovery & Selection Stability Study Sequencing Verification CQA Verification Scale-up Selection Sequencing Verification CQA Verification Master Cell Bank GMP Production Cell Banking Cell Banking Cell Banking Streamline Data Analysis and Management Genedata digital solutions increase efficiency and traceability, ease collaboration and enable innovation Developing an optimal cell line is a time-intensive and costly yet crucial step in the production of high-quality biologics. Throughout the CLD process, extensive data on clone performance is exchanged between various analytical and processing teams. By meticulously analyzing, structuring and centralizing the data, biopharma companies can accelerate CLD and implement AI-based prediction and modeling of clone behavior. The multi-attribute method (MAM) provides multiple readouts from a single assay and is increasingly replacing traditional methods for assessing candidate cell lines. These include next-generation sequencing (NGS) to select stable clones and mass spectrometry to complement chromatographic techniques. Software that streamlines analysis for CLD applications of these complex technologies is key to leveraging their power. Genedata digital solutions ensure data traceability, support collaboration and enable teams to take advantage of the latest innovative technologies to increase CLD efficiency. The software can be deployed in both enterprise and validated environments with minimal customization. Purpose-built and aligned with industry best practices, the Genedata solutions (used individually or together) contain all the necessary business logic to structure and automate CLD workflows. Genedata Bioprocess streamlines and ensures traceability along the entire CLD process. It tracks all plate operations, passages, and expansions, manages cell inventory, and registers pools, clones, and analytical results. Genedata Bioprocess can directly integrate with bioreactors and analyze online, at-line and offline data, efficiently monitoring key growth characteristics such as productivity (qP) and integrated viable cell density (IVCD). Scientists can visualize results in dynamic, interactive plots and panels, rapidly select the best clones and perform mechanistic modeling of clone behavior. With its end-to-end coverage, Genedata Bioprocess can integrate with laboratory automation equipment and label Genedata Bioprocess - Structured Knowledge Management System for E2E Bioprocess Development Genedata Selector Software - Targeted Locus Amplification (TLA), Genome Stability, Variant Detection, Sequence Verification, Contamination Genedata Expressionist SoftwareMass spectrometry data analysis Genedata Selector Software Genedata Expressionist Software Data Solutions 17 CLD Workflow Vector Construct & Sequence Verification Stable Transfection & Selection Mini-pool Screening Single Cell Cloning Clone Recovery & Selection Stability Study Sequencing Verification CQA Verification Scale-up Selection Sequencing Verification CQA Verification Master Cell Bank GMP Production Cell Banking Cell Banking Cell Banking Genedata Bioprocess - Structured Knowledge Management System for E2E Bioprocess Development Genedata Selector Software - Targeted Locus Amplification (TLA), Genome Stability, Variant Detection, Sequence Verification, Contamination Genedata Expressionist SoftwareMass spectrometry data analysis Genedata Selector Software Genedata Expressionist Software Data Solutions printers and scanners to produce and track barcodes, ensuring that no sample is lost. Complete clone history reports can also be created with a single click. Genedata Selector enables CLD groups to bring the speed and sensitivity of NGS technology in-house. Wizard-based playbooks guide users through NGS analysis workflows such as integration site confirmation, mutational profiling using single-cell RNA Seq, gRNA design for CRISPR-based gene editing and biosafety monitoring. Genedata Selector is instrument-agnostic, automates all NGS data management, processing, and analysis, and serves as a single source of truth for NGS-based assays, allowing CLD teams to easily collaborate and track their work. Additionally, the software has GMPcompliant functionalities for in-house validation and execution of NGS-based workflows and is 21 CFR Part 11 compliant. Genedata Expressionist enables analytical groups to leverage mass spectrometry (MS) methods to ensure that cell lines produce proteins with the desired characteristics and quality. This instrument-agnostic system automates MS data processing and ensures standardized analysis and reporting. Covering workflows such as high-throughput host cell protein analysis and intact mass analysis, Genedata Expressionist accelerates CLD with customers reporting up to a 95% reduction in MS data analysis time. 18 We believe the scientific community goes further, faster when we go there together. We provide the research and clinical communities with expert scientific support, highly validated antibodies, assays and other tools to address important targets in critical biological pathways. Today, we help 750,000 researchers in over 130 countries reach results faster in areas like cancer, neurological disorders, infectious diseases and metabolic disorders. With a relentless mission to empower those seeking answers to life’s important scientific questions, Beckman Coulter Life Sciences is a preferred laboratory partner providing automation and innovation solutions for Centrifugation, Flow Cytometry, Genomics, Particle Analysis and Liquid Handling workflows. With a legacy dating back to 1935, our technologies reduce manual laboratory processes and can provide greater speed, accuracy and advanced analytics to accelerate answers with a guiding focus to improve patient care and enable pioneering discoveries. Learn More Learn More We make cutting-edge R&D possible for leading Life Science companies around the world, accelerating innovation that helps people lead longer, healthier lives. We have a proud record of partnering with academic, clinical and government scientists, applying our scientific and operational expertise to help them understand diseases and infections, pioneer more effective treatments and develop more efficient workflows. Across the Life Sciences, we work collaboratively to drive advancements toward real-life impact. Learn More 19 Molecular Devices makes scientific breakthroughs possible for academic, pharmaceutical, government and biotech customers. Dedicated to enabling life science labs of the future, where innovative technology and novel research converge, Molecular Devices empowers scientists to advance discovery, driving earlier diagnoses and safer therapeutics for patients. Headquartered in Silicon Valley, Calif., with a footprint around the world, the company’s 1,200 diverse associates are moved by a vision to improve quality of life everywhere. Learn More Leica Microsystems develops and manufactures microscopes and scientific instruments for the analysis of microstructures and nanostructures. Ever since the company started as a family business in the nineteenth century, its instruments have been widely recognized for their optical precision and innovative technology. It is one of the market leaders in compound and stereo microscopy, digital microscopy, confocal laser scanning microscopy with related imaging systems, electron microscopy sample preparation and surgical microscopes. Leica Microsystems is a subsidiary of Danaher, a leading global life sciences and diagnostics innovator, committed to accelerating the power of science and technology to improve human health. Learn More We help BioPharma companies seeking a trusted partner for compliant workflows, data management and insights. IDBS provides cloud software from R&D through Manufacturing to help our customers unlock the potential of AI/ML to improve the lives of patients. With 35 years of experience and industry-leading partnerships, IDBS has supported our innovative customers with flexible, scalable solutions for assured confidence in both GxP and non-GxP environments. Learn More Genedata transforms data into intelligence with enterprise software solutions that accelerate the pace of biopharma R&D. Our cutting-edge solutions incorporate extensive biopharma R&D domain knowledge to digitalize and automate data-rich and complex R&D processes. With over 25 years of success due to closely-knit teams of scientists, software engineers and business experts, Genedata solutions help maximize the ROI in R&D expenditure from early discovery all the way to the clinic. Learn More 20 SCIEX empowers our customers to solve the most impactful analytical challenges in quantitation and characterization. With groundbreaking innovation and outstanding reliability and support, SCIEX has been at the forefront of the field for over 50 years. Since the launch of the first-ever commercially successful triple quadrupole in 1981, we continue to develop technologies and solutions that influence life-changing research and outcomes. That’s why thousands of life science experts around the world choose SCIEX to get the answers they can trust. Learn More For research use only. Not for use in diagnostic procedures.© 2024 DH Life Sciences LLC. © 2024 Abcam Limited. Valita and Valita Titer are trademarks or registered trademarks of ValitaCell in the United States and other countries. ValitaCell is a Beckman Coulter Company. © 2024 Beckman Coulter, Inc. Beckman Coulter, the stylized logo, and the Beckman Coulter product and service marks mentioned herein, including Biomek, are trademarks or registered trademarks of Beckman Coulter, Inc. in the United States and other countries. All other trademarks are the property of their respective owners. © 2024 Genedata AG. © 2024 ID Business Solutions, Ltd. © 2024 Molecular Devices, LLC. The trademarks used herein are the property of Molecular Devices, LLC or their respective owners. Specifications are subject to change without notice. © 2024 Phenomenex, Inc. © 2024 DH Tech. Dev. Pte. Ltd. Trademarks and/or registered trademarks mentioned herein, including associated logos, are the property of AB Sciex Pte. Ltd. or their respective owners in the United States and/or certain other countries. Intabio is being used under license. All rights reserved. Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in academic, pharmaceutical, biotech, environmental, clinical research, government and industrial laboratories. From drug discovery and pharmaceutical development to food safety and environmental analysis, Phenomenex chromatography solutions accelerate science and help researchers improve human health and well-being. Phenomenex is an operating company within the Life Sciences group of Danaher Corporation. Learn More 21
