Lab Manager | Run Your Lab Like a Business

Resource Guide

Best Practices for Biosafety Cabinet Maintenance and Use

Maximizing performance, safety, and sustainability with proper biosafety cabinet management

Biosafety cabinets (BSCs) are essential for protecting the safety of lab personnel, the environment, and samples when working with biohazardous agents. They can significantly reduce the risk of biohazard exposure by filtering air through high-efficiency particulate air (HEPA) filters before it is exhausted into the lab or outside environment. However, the complexity of BSC maintenance and operation, including decontamination strategies, can present substantial challenges. 

Best Practices for Biosafety Cabinet Maintenance and Use

Lab managers must determine optimal maintenance and cleaning routines to prolong BSC lifespan and ensure performance. This involves regular certification and testing of HEPA filters, along with adherence to stringent decontamination processes. The selection of disinfectants requires careful consideration to ensure efficacy against a broad range of contaminants and compatibility with the materials that make up the interior of the BSC. 

Adopting best practices can allow a BSC to run well for decades before needing replacement, though it is important to recognize when they require an update. Luckily, many of the physical signs of needing a new BSC, like rust, are easy to recognize. Other reasons to upgrade include improved ergonomics and potential energy savings. 

Best practices for BSCs also include how they are used. Lab personnel must have a thorough understanding of the types of work appropriate for different BSC classes, adhere to protocols that minimize biohazard exposure, and implement practices that maintain sample integrity. Establishing comprehensive training programs can equip personnel with the required knowledge and skills for safe and effective BSC operation. 

Download this eBook to learn more about:

  • Selecting the right BSC for your lab
  • Effective BSC decontamination and maintenance practices
  • Creating a BSC training program
  • BSC features for enhanced sustainability and safety

Sponsored by