Next-generation sequencing (NGS), quantitative reverse transcription PCR (qRT-PCR), and digital PCR are powerful tools for analyzing genetic material and circulating biomarkers, facilitating research in oncology, microbiomes, pharmacogenomics, infectious and autoimmune diseases, and multiomic viral studies. However, their success hinges on proper sample preparation.
Biomedical and multiomics research depends on carefully isolated genetic material (DNA and RNA) and circulating biomarkers like circulating tumor cells (CTCs). Ensuring quality findings requires consistent and reproducible sample preparation. Traditional methods can be lengthy, cumbersome, and involve hazardous chemicals, but robust, high-throughput commercial solutions simplify and accelerate the process.
Automated sample purification instruments using magnetic bead-based technology moves the beads instead of the liquids. This results in higher purity because no non-target organic matter or contaminates from liquid reagents are transferred from well to well. The analyte of interest binds to the bead - even from challenging sample time including Formalin-fixed paraffin-embedded samples.
The field of biomedical and multiomics research is experiencing rapid advancements, primarily attributed to the meticulous and thorough preparation of samples. This process is crucial in generating data that is of high quality and significance. To assist researchers in this endeavor, this compilation of application notes provide a comprehensive overview of an automated sample purification instrument. These notes cover a wide range of research areas, including microbiome research, multiomic viral research, and cancer research, showcasing the instrument’s versatility.
By exploring these application notes and carefully reviewing the accompanying data, researchers can gain valuable insights into best practices and emerging techniques. This knowledge will enable them to optimize their workflows and achieve more reliable and accurate results in their research endeavors.
