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Analytical Techniques to Uncover the Biological Burden of 'Forever Chemicals'

Join Lab Manager and our expert as we discuss high-resolution mass spectrometry in PFAS analysis

TechTrends Webinar

Available On Demand

Per/polyfluoroalkyl substances (PFAS) (also known as “forever chemicals”) are highly persistent, ubiquitous environmental contaminants associated with adverse health effects in humans and animals. PFASs are traditionally monitored via liquid chromatography with tandem mass spectrometry (LC-MS/MS). However, the discovery of thousands of PFASs, many of which do not have analytical standards, has made comprehensive characterization impossible using targeted methods. 

A significant fraction of total organofluorine in biological samples (e.g., human blood serum) is not captured by targeted LC-MS/MS. The speaker will discuss progress and remaining challenges in using high-resolution mass spectrometry (HRMS) to comprehensively capture total PFAS burden accumulating in tissues and fluids of living organisms.


Carrie McDonough, PhD
Assistant Professor, Chemistry
Carnegie Mellon University

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