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2013 HPLC System Product Survey Results

High-performance/pressure liquid chromatography (HPLC) is, for many scientists, an essential chromatographic technique.

by Lab Manager

High-performance/pressure liquid chromatography (HPLC) is, for many scientists, an essential chromatographic technique. HPLC systems used for the separation, identification, purification and quantification of various chemical and biochemical solutions are composed of a pump, a sample injector, a separation column, a detection unit, and a data-processor.

Top 6 Questions You Should Ask When Buying an HPLC System

  1. How flexible is the system? Can the system be optimized to meet your laboratory requirements?
  2. What tubes, vessels, and vials can it accommodate? Can components (such as additional detectors, valves, etc.) be upgraded in the future?
  3. Is the software easy to use and operate? Can a demo version be put in place to get a feel for how the software functions for your laboratory’s workflow?
  4. How is the system (not just components) qualified during installation to meet manufacturer performance expectations?
  5. Who provides the support and service for the product? Is it the manufacturer or a third party service group? If it is a third party service group, are they factory-trained?
  6. Finally, ask about the total cost of the purchase—not just the price of the product being installed— but the total cost of ownership, which includes price, service expectations, warranty, etc.


Top ten features/factors survey respondents look for when buying an HPLC system: 

Accuracy 100%
Precise and accurate flow rates 100%
Quality of data 100%
Resolution 100%
Maintenance 98%
Sensitivity 98%
Availability of supplies and accessories 96%
Price 94%
Ease-of-use 93%
Service and Support 91%


Additional HPLC system components being used by respondents:

Autosampler 82%
Degasser 75%
Column heater 72%
Data system 70%
Automated valve 30%
Fraction collector 21%
Solvent recyler 9%


Services & schedules being used by respondents' labs for their HPLC instruments:

As needed depending upon the condition of the instrument 54%
Routine instrument service 47%
Instrument repair 39%
Planned/scheduled according to time/date of last service 32%
Non-warranted instrument services 18%
Planned/scheduled according to the SOP 11%
Planned/scheduled accoring to usage/number of analyses 3%


HPLC separation mode(s) being utilized by respondents:

Reverse Phase 76%
Normal Phase 47%
Ion Exchange 30%
Size Exclusion (SEC) 21%
Ultra-high performance (UHPLC) 20%
Ion chromatography 17%
Gel permeation (GPC) 12%
Gel filtration (GFC) 12%
Affinity 11%
Hydrophilic Interaction (HILIC) 9%
Chiral 9%
Ion exclusion 9%


Types of detector(s) being used by respondents:

UV-Vis 72%
Flourescent 36%
Ultraviolet (UV) 34%
Mass Spectroscopy (MS) 33%
Refractive Index (RI) 32%
Conductivity 26%
Light Scattering (LS) 16%
Electrochemical 9%
Other 11%

 For more information on HPLC systems, including useful articles and a list of manufacturers, visit

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