Biotage, a global leader in automated flash purification, tools and technology for medicinal and analytical chemistry, announced it has recently been awarded U.S. patent 7686959: Control system and Method for Flash Separation. The patented technology converts thin-layer chromatography (TLC) compound retention data into a linear gradient and also provides the user with sample loading estimates for any Biotage flash cartridge.

This novel “TLC-to-Gradient” technology removes all of the trial and error associated with developing flash purification methods.

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Recently, Biotage launched related gradient technology for its Isolera™ flash purification product line. The enhanced gradient optimization (GO) technology can reduce solvent use and cost by 60% or more. With GO technology, results from linear gradients can be purified at a larger scale with an optimized step gradient, which reduces solvent use by as much as 60%. The GO solvent saving feature is available on all new Isolera systems. As many in the medicinal chemistry arena institute “green chemistry” initiatives, Biotage continues to evolve its products to aid its customers and the environment.

Source: Biotage