Lab Manager | Run Your Lab Like a Business


How to Reduce Carryover in Liquid Chromatography

Save time, start batches earlier, run more samples, and report results sooner with an optimized UHPLC system 

Reduce carryover and ensure a high throughput LC/MS assay

Carryover is a phenomenon where you see a peak from the previous injection remaining in the current injection. When basic compounds are analyzed with a typical C18 column, their peak shape can become deformed (e.g., tailing) due to nonspecific interactions with residual silanols on the surface of the packing materials. 

LC/MS/MS is one of the most powerful techniques for a quantitative assay due to its superior selectivity and sensitivity. Having a high-quality HPLC system to reduce carryover and ensure high throughput is essential for today’s laboratories.

This resource explores: 

  • How to optimize a front-end UHPLC system for higher throughput
  • Critical features required for high-throughput LC/MS assays
Infographic Thumbnail explaining how to reduce carryover in liquid chromatography 

Download the free infographic and white paper now to learn more about a future without carryover, courtesy of Shimadzu.

Sponsored by