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Does Your Lab Struggle with Reliable Osmolality Testing?

Osmolality and high concentration mAb formulations

Osmolality testing has several unique and essential applications throughout bioprocessing, and new use cases are constantly emerging. As the field of biologics manufacturing matures, osmometers and other analytical devices must keep up and even offer new options to remain valuable. 

The osmolality of monoclonal antibody (mAb) formulations is typically determined using freezing point depression or vapor pressure osmometers. The wider use of subcutaneous injections, an injection that requires less volume but increased concentration to alleviate patient pain and increase patient compliance, has led to a trend in increasing mAb concentrations. This higher concentration, however, can pose analytical issues. Due to much higher viscosities being seen in drug formulations. it is critical to have an instrument that will measure concentration with optimal performance. 

Download this whitepaper now to learn more about using osmometers as a means of measuring concentrated protein formulations. 

Osmolality and high concentration mAb formulations

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