Liquid chromatography coupled to mass spectrometry (LC-MS) is the most widely used method to detect per- and polyfluoroalkyl substances (PFAS) in drinking water. As the need for PFAS analysis expands beyond water samples to include soil, tissues, and more, robust methods and workflows are needed to ensure accurate and reliable data.

PFAS pose unique challenges for analysis. Often present in trace amounts, they require the high degree of sensitivity and low detection limits offered by LC/MS analysis for accurate detection. Contamination is a pervasive concern, as they can persist in LC instruments, consumables, and other laboratory items. Complex matrices, especially those contained in environmental samples like soil and wastewater, can also interfere with analysis.
In 2019 the Environmental Protection Agency (EPA) released a solid-phase extraction (SPE) LC-MS/MS method for testing PFAS in drinking water. Since then, new methods have been released for analyzing PFAS in a wide range of sample matrices, including soil, groundwater, and biological tissue, among others. These standardized approaches address many challenges associated with PFAS testing.
Download this resource guide to:
- Gain a comprehensive understanding of the role of LC in PFAS detection
- Explore the latest advancements in LC PFAS detection, designed to help labs newly developing or expanding their PFAS testing processes
- Learn how to optimize LC workflows to maintain regulatory compliance
- Read guidance on LC purchasing decisions
- View a reference chart of relevant EPA standard methods