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Optimizing Drug Efficacy Testing in Cancer Research Using 3D Cell Culture Automation

Automated 3D cancer cell culture systems set the pace for efficient drug efficacy testing and discovery of therapeutic targets

The development of efficient anti-cancer drugs and drug combinations as well as optimized and representative testing methods for the discovery of viable therapeutic targets is crucial for successful cancer therapies. 

Optimizing Drug Efficacy Testing in Cancer Research Using 3D Cell Culture Automation

3D cancer cell models, such as tumoroids, have emerged as highly valuable tools in this aspect for cancer research and drug development. By mimicking the three-dimensional structure and microenvironment of actual tumors, tumoroids provide a realistic and predictive platform for evaluating drug responses. 

Yet, despite their potential, manual 3D cell culture workflows are time-consuming, error prone, and inconsistent, posing significant challenges for their adoption in high-throughput drug screening. The™ Automated Cell Culture System helps expedite and standardize the spheroid assay by automating key processes including plating, passaging, media exchange and organoid monitoring in response to compound treatments.

By helping automate these processes, the Automated Cell Culture System expedites the 3D cell culture processes while enhancing research reproducibility and accuracy which provides for reliable anti-cancer drug discovery.

Download this app note to learn about: 

  • Automation of a colorectal cell culture workflow using 3D spheroids from HCT116 cell lines in U-shape low attachment plates
  • Automation of entire 3D cell culture process, from assay set-up screening and imaging to data analysis
  • Increasing confidence in drug screening readouts 
  • Generating actionable insights for high-throughput drug discovery and precision medicine applications

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