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App Note

Run Toxic, Nutritional, and Implant Markers in a Single Urine Panel

Eliminate acid digestion and spectral interferences using multi-quadrupole ICP-MS for complex biological matrices

Written byPerkinElmer

Multi-element urine panels typically involve separate analytical runs—one for trace toxics, another for nutritional elements, potentially a third for implant monitoring markers.

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This application note demonstrates how extended dynamic range inductively coupled plasma mass spectrometry (ICP-MS) consolidates these panels into a single two-minute method. The NexION 5000 measures beryllium at 0.0004 µg/L alongside magnesium at mg/L levels using simple 1:10 dilution. The method handles toxic metals (Pb, As, Hg, Cd), essential nutrients (Zn, Cu, Se, Mg), and implant markers like cobalt in one run.

Download the application note to:

  • Learn how dilute-and-shoot sample prep replaces acid digestion to reduce prep time and contamination risk
  • See how MS/MS modes with NH₃ and O₂ reaction gases eliminate argon-, chloride-, and oxide-based interferences
  • Use detection limits and recovery data to evaluate whether this consolidated approach fits your clinical workflow

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