Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become indispensable in environmental, food, and pharmaceutical laboratories due to its high precision, specificity, and sensitivity. But in practice, the method can present familiar bottlenecks.
In applications like PFAS analysis, challenges such as labor-intensive sample preparation and background contamination can limit a lab’s ability to operate efficiently and remain compliant. These technical hurdles are compounded by growing workloads and increasing regulatory scrutiny. For example, ISO 17025-accredited labs, or those pursuing accreditation, must demonstrate technical competence alongside quality measures such as thorough documentation, traceability, and method validation.
This compendium brings together strategies for streamlining sample preparation, reducing contamination risks, and increasing throughput, while also addressing the documentation and quality requirements tied to regulatory compliance. It explores validated methods for PFAS analysis, as well as key considerations for data integrity, accreditation, and audit readiness.
Download this compendium to discover:
- How validated LC-MS/MS workflows based on EPA Methods 537.1 and 533 can increase throughput, reduce contamination risk, and shorten runtimes
- What lab managers need to know about the EPA’s Fifth Unregulated Contaminant Monitoring Rule (UCMR 5)
- How automation can help reduce sample preparation time and cost of analysis
- Key factors for achieving and sustaining ISO 17025 accreditation
