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The Right Choice For Mass Spectrometry Systems

An analytical method that involves generating charged molecules or molecular fragments and measuring their mass-to-charge ratio through the ionization of chemical samples, mass spectrometry (MS) is a key part of many laboratories.

Rachel Muenz

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The AB SCIEX TripleTOF 4600 is a ‘workhorse’ system that brings the excellent functionality of TripleTOF technology to routine analysis. TripleTOF technology is considered a leading platform for simultaneous qualitative and quantitative analysis, integrating the highest available sensitivity and speed with high resolution and accurate mass to generate better quality information from every sample.

• Acquires high resolution accurate mass MS and MS/ MS data at up to 50 spectra per second

• Integrates comprehensive qualitative exploration, rapid profiling, and high-resolution quantitation workflows on a single platform

• Over 50 hours of continuous LC/MS operation provides


Bruker’s new SCION series is more sensitive and robust than previous GC-MS instruments, and comes in a very compact bench space saving footprint that is far smaller than for conventional GCtriple quadrupole MS systems. The SCION TQ includes compound based scanning (CBS) technology, ideal for the automation and optimization of quantitative analytical methods.

• Offers excellent performance and ease of use

• Designed especially to enhance data quality and productivity for analysts working in routine testing and applied markets

• Features the industry’s first ion ‘lens-free’ technology

• Significantly more sensitive and robust than previous GC-MS instruments

• Comes in a very compact bench space-saving footprint

Advion expression™ Compact Mass Spectrometer

The expression from Advion is a compact, fume hooddesigned single quadrupole mass spectrometer for chemists to save time and money, provide crucial information quicker, and speed-up post-purification mass confirmation. This high performance mass spec is compatible with both HPLC and UPLC as well as manual liquid injection.

• Provides high performance

• Half the size and half the price of conventional single quadrupole systems

• Compact size allows it to be placed in a fume hood or on the bench for direct access and immediate results for chemists in a variety of disciplines that require mass confirmation, reaction monitoring, QC and purity analysis

Shimadzu 8040 Triple Quadrupole LC-MS

Shimadzu’s LCMS-8040 triple quadrupole mass spectrometer combines newly improved ion optics and collision cell technology with proprietary ultra-fast technologies. This expands the application range and ensures high-sensitivity, high-throughput analysis at lower levels of detection. The 8040’s LabSolutions LC-MS software offers a variety of data processing features, including a Quantitation Browser and a Data Browser.

• Incorporates newly improved ion optics (UF-LensTM), which integrate two multi-pole RF ion guides, and UFsweeper™ II collision cell technology

• Provides higher multiple reaction monitoring (MRM) sensitivity

• Other improvements also yield higher sensitivity for scan mode measurements, expanding the potential range of LC/MS/MS applications

• Features very fast polarity, switching at 15 msec

An analytical method that involves generating charged molecules or molecular fragments and measuring their mass-to-charge ratio through the ionization of chemical samples, mass spectrometry (MS) is a key part of many laboratories. For example, MS is utilized for determining the chemical structures of molecules, such as peptides, and can also determine the elemental composition of a sample. MS systems come in two main types: standalone and integrated. Standalone systems involve just MS and there are several different techniques to ionize the sample, such as ICP-MS, MALDI, FTICR mass spectrometry, and TIMS. The average MS system is made up of a detector, a mass analyzer, and an ion source. Integrated systems combine MS with different separation techniques in one powerful instrument. Examples of integrated systems include a variety of different GC-MS systems and LCMS systems, along with GC-MS-MS. With so many choices when it comes to MS, choosing the right system for your lab can be very difficult but the main question you need to answer is what samples you will be analyzing. Consulting your vendor is also a good idea to help you pick exactly what you need.


• Food testing
• Environmental analysis
• Clinical research
• Protein characterization
• Forensic analysis
• Space exploration
• Trace gas analysis
• Isotope dating and tracking