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High performance liquid chromatography has been one of the defining separation techniques of the last 40 years, and its importance and range of uses will likely increase in the coming years.

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High performance liquid chromatography has been one of the defining separation techniques of the last 40 years, and its importance and range of uses will likely increase in the coming years. This page, compiled by Lab Manager Magazine, combines articles, events and resources all related to the advancement of UHPLC technology.

Today, capital outlays for most UHPLC systems are between 20 and 40 percent higher than HPLC. As such, this added cost remains a sticking point for potential adopters. Yet, one can make a reasonable case that UHPLC can save money in the long run by offering higher efficiency and faster throughput.

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UHPLC Company News

Dionex Inc. Dionex First to Introduce UHPLC Compatibility Across Entire Range of HPLC Products

Restek Inc. Easy Transfer of HPLC Methods to UHPLC

Featured UHPLC Systems

Dionex UltiMate 3000 w/UHPLC Compatibility
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PerkinElmer Flexar FX-10 UHPLC
PerkinElmer Flexar FX-10
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Waters Acquity UPLC
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Shimadzu Scientific Nexera
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Agilent 1290 Infinity LC System
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Thermo Scientific Accela
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UHPLC Articles from Lab Manager Magazine in 2010:

UHPLC by Angelo DePalma
Although less than a decade old, UHPLC ultra high-performance liquid chromatographs have become the de facto performance standard despite lagging far behind conventional HPLC in total systems sold...Read More

Evolution of HPLC Systems by John Buie
High performance liquid chromatography (HPLC) is, for many scientists, an essential piece of apparatus for the separation, identification, purification and quantification of various compounds. Users of HPLC work in a variety of fields including biomedical research, and the cosmetics, energy, food and environmental industries...Read More

Product Focus: HPLC Columns
High-performance liquid chromatography (HPLC) columns are rightly considered the “heart” of the instrument because that is where the separations occur. Columns consist of stainless steel tubes with inlet and outlet openings... Read More 

A More Efficient Pharmaceutical Industry -
Waters Corporation
Amid increasing interest by pharmaceutical manufacturers and regulatory bodies to apply quality by design (QbD) principles to processes and product, organizations are beginning to recognize that QbD can be a catalyst to facilitate continuous improvement... Read More

Shimadzu Releases Newsletter for Researchers Working with UHPLC
Shimadzu Scientific Instruments released a special edition of its LC World Talk newsletter for researchers and scientists who work with UHPLC techniques... Read more









Featured UHPLC White Papers and Application Notes

Grace Davison Discovery Sciences
HPLC and UHPLC Methods for Melamine

Migration of Nutraceutical Methods from HPLC to UHPLC
Increased Throughput and Reduced Solvent Consumption for the Determination of Isoflavones by UHPLC
Requirements for UHPLC Instruments, Method Development in UHPLC and Method Transfer From Regular HPLC to UHPLC
Reduced Solvent Usage and Increased Throughput for PAH Analysis Using UHPLC
Rapid UHPLC Determination of Common Preservatives in Cosmetic Products
Rapid UHPLC Determination of Common Antioxidants in Edible Oils
Fast Analysis of Fat-Soluble Vitamins Using Flexar FX-10 and Chromera CDS
UHPLC Separation and Detection of Bisphenol A (BPA) in Plastics

Rapid Analysis of Polycyclic Aromatic Hydrocarbons in Seafood

Waters Corporation
• A QbD with Design-of-Experiments Approach to the Development of a Chromatographic Method for the Separation of Impurities in Vancomycin

HPLC Assay Method for Drug Products Containing Anti-Tuberculosis Active Pharmaceutical Ingredients
Determination of Acylglycerols in Biodiesel

Featured Webinars

Integrated Solutions to Rapid, QbD-Compliant Method Development Sponsored by Waters Corporation



Additional Resources


Thermo Scientific:
Accela LC Systems

UltiMate 3000 LC Systems
UltiMate 3000 RSLCnano LC System


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Data Sheets

UltiMate 3000 RSLCnano LC System
UltiMate 3000 Series Rapid Separation Pumps

Nexera Application Data Sheet No. 1
Nexera Application Data Sheet No. 2
Nexera Application Data Sheet No. 3