Labmanager Logo

A Toast to the Proteins in Dinosaur Bones

Fossil soft tissue in dinosaur bones has been a controversial topic among researchers for quite some time

| 2 min read
Share this Article
Register for free to listen to this article
Listen with Speechify
0:00
2:00

dino-bonesDinosaur blood vessel with adjacent bone matrix that still contains bone cells. These structures have a perfect morphological preservation over hundreds of millions of years, but are chemically transformed through oxidative crosslinking. The extract comes from a sauropod dinosaurCREDIT: Jasmina Wiemann / Yale University

Burnt toast and dinosaur bones have a common trait, according to a new Yale-led study. They both contain chemicals that, under the right conditions, transform original proteins into something new. It's a process that may help researchers understand how soft-tissue cells inside dinosaur bones can survive for hundreds of millions of years.

A research team from Yale, the American Museum of Natural History, the University of Brussels, and the University of Bonn announced the discovery Nov. 9 in the journal Nature Communications.

Lab manager academy logo

Get training in Lab Crisis Preparation and earn CEUs.

One of over 25 IACET-accredited courses in the Academy.

Certification logo

Lab Crisis Preparation course

Fossil soft tissue in dinosaur bones has been a controversial topic among researchers for quite some time. Hard tissues, such as bones, eggs, teeth, and enamel scales, are able to survive fossilization extremely well. Soft tissues, such as blood vessels, cells, and nerves—which are stored inside the hard tissue—are more delicate and thought to decay rapidly after death. These soft tissues are composed mainly of proteins, which are believed to completely degrade within about four million years.

Yet dinosaur bones are much older, roughly 100-million-years-old, and they occasionally preserve organic structures similar to cells and blood vessels. Various attempts to resolve this paradox have failed to provide a conclusive answer.

"We took on the challenge of understanding protein fossilization," said Yale paleontologist Jasmina Wiemann, the study's lead author. "We tested 35 samples of fossil bones, eggshells, and teeth to learn whether they preserve proteinaceous soft tissues, find out their chemical composition, and determine under what conditions they were able to survive for millions of years."

The researchers discovered that soft tissues are preserved in samples from oxidative environments such as sandstones and shallow, marine limestones. The soft tissues were transformed into Advanced Glycoxidation and Lipoxidation end products (AGEs and ALEs), which are resistant to decay and degradation. They're also structurally comparable to chemical compounds that stain the dark crust on toast.

AGEs and ALEs are characterized by a brownish color that stains fossil bones and teeth that contain them. The compounds are hydrophobic, which means they are resistant to the normal effects of water, and have properties that make it difficult for bacteria to consume them.

Interested in Life Science News?

Subscribe to our free Life Science Tools & Techniques newsletter.

Wiemann and her colleagues made their discovery by decalcifying fossils and imaging the released soft tissue structures. They applied Raman microspectroscopy—a non-destructive method for analyzing both the inorganic and organic contents of a sample—to the extracted fossil soft tissues. During this process, laser energy directed at the tissue causes molecular vibrations that carry spectral fingerprints for the chemicals that are present.

Co-author Derek Briggs, Yale's G. Evelyn Hutchinson professor of Geology and Geophysics and a curator at the Yale Peabody Museum of Natural History, said the study points to localities where soft tissue may be found in fossil bones, including sandstones deposited from rivers, dune sands, and shallow marine limestones.

"Our results show how chemical alteration explains the fossilization of these soft tissues and identifies the types of environment where this process occurs," Briggs said. "The payoff is a way of targeting settings in the field where this preservation is likely to occur, expanding an important source of evidence of the biology and ecology of ancient vertebrates."

Loading Next Article...
Loading Next Article...

CURRENT ISSUE - October 2024

Lab Rats to Lab Tech: The Evolution of Research Models

Ethical and innovative scientific alternatives to animal-based R&D

Lab Manager October 2024 Cover Image
Lab Manager Life Science eNewsletter

Stay Connected with Life Science News

Click below to subscribe to Life Science Tools & Techniques eNewsletter!

Subscribe Today