Thermo Fisher Scientific has released a technical note (TN) that challenges the common misconception that there is significant variation in high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD) peak area response of oligosaccharides.

Traditional approaches for research into tumor formation have revolved around histological classification

Gary W. Procop, MD, MS, chair of the Department of Molecular Pathology, section head of molecular microbiology, and director of mycology and parasitology at the Cleveland Clinic, talks to contributing editor Tanuja Koppal, PhD, about the clinic’s $75 million state-of-the-art medical testing laboratory that opened in 2012. The building houses microbiology, molecular pathology, cytogenetics, and immunopathology as well as administrative offices. He talks about the thinking that went into designing the building and its labs and shares some insights on what people need to consider when embarking on such initiatives, however small or large. He emphasizes that both people and laboratories should always be open to change, making way for new advancements in science and technology.

Problem: Users in EM facilities with several current generation tools including FE SEM and dual beam FIB/SEM will, despite taking precautions to insert only clean specimens, sometimes get contamination introduced into their microscopes. This manifests itself as a dark rectangle on areas which have been exposed to the incident beam. How can this be prevented? Can it be removed from the previously exposed samples?