BIA Separations‘ CIMmultus™ range

BIA Separations

As part of BIA Separations‘ CIMmultus™ range, PrimaS is a key addition to the company‘s mRNA purification toolbox, including Oligo dT-18, C4-HLD, and SDVB chemistries.

Multi-Mode Ligand Bioprocessing Technology to Facilitate Development of Advanced Therapeutics

Novel platform initially focused on high-resolution industrial scale processing of therapeutic mRNA

| 2 min read
Register for free to listen to this article
Listen with Speechify
0:00
2:00

AJDOVŠCINA, SLOVENIA — June 16, 2020 — BIA Separations, a leading bio-chromatography development and manufacturing company, today announced the introduction of its novel PrimaS™ ligand technology. The proprietary multi-use platform facilitates high-resolution and high speed processing and addresses many underserved but critical separation problems in the context of fast emerging advanced therapy medicinal products (ATMPs). The first application of PrimaS technology being made available is for mRNA purification addressing a rapidly growing interest in mRNA-based therapies.

As part of BIA Separations‘ CIMmultus™ range, PrimaS is a key addition to the company‘s mRNA purification toolbox, including Oligo dT-18, C4-HLD, and SDVB chemistries. The platform harnesses mRNA capturing and polishing strategies, including dsRNA impurity removal and mRNA sizing options. All technologies are easily scalable from lab to manufacturing, and are able to provide better product quality than traditional purification systems.

Lab manager academy logo

Get training in Lab Crisis Preparation and earn CEUs.

One of over 25 IACET-accredited courses in the Academy.

Certification logo

Lab Crisis Preparation course

mRNA manufacturing involves several complex bioprocessing steps beginning with plasmid DNA production and its linearization, followed by in vitro transcription (IVT). Both operations include finely balanced enzymatic reactions, utilizing a number of key raw materials. For the standards required for clinical applications, ultra-pure mRNA is required, with critical contaminants eliminated, including dsRNA, template DNA and respective enzymes, in addition to potential impurities from raw materials such as chromatin-like structures and endotoxins.

Significant progress has been made by researchers around the globe to sharpen concepts that exploit mRNA-based therapeutics, with as examples, many protein replacement, immuno-oncology and vaccine approaches, already progressing to early clinical stages. COVID-19 exemplifies the need for these advancements, acting as a catalyst to now further accelerate such developments. 

"From the very beginning, BIA Separations positioned itself as a technology-enabling company, supporting scientists to solve the most difficult separation challenges faced in the development of genetic medicines," said Ingo Nagler, business development officer at BIA Separations. "The new PrimaS technology significantly contributes to this objective, whilst ensuring patient safety remains at the forefront of our work."

To learn more about BIA Separations’ novel PrimaS technology, please follow this link: www.biaseparations.com/en/products/monolithic-columns/products-for-preparative-applications/214/primas

To view BIA Separations‘ mRNA portfolio, please follow this link: www.biaseparations.com/en/featured/messenger-rna

Interested in life sciences?

Subscribe to our free Life Sciences Newsletter.

Is the form not loading? If you use an ad blocker or browser privacy features, try turning them off and refresh the page.

Loading Next Article...
Loading Next Article...

CURRENT ISSUE - January/February 2025

Energizing Leadership in Action

The science-backed behaviors that help leaders inspire thriving teams and organizations

Lab Manager January/February 2025 Cover Image