Our two highlighted tradeshows this month include the Materials Research Society Fall Meeting and Exhibit (MRS) and the American Society for Cell Biology’s annual meeting (2014 ASCB/IFCB). The 2014 MRS Fall Meeting takes place November 30-December 5, 2014 in Boston, Massachusetts, featuring over 6,000 presentations. Not long after, the 2014 ASCB/IFCB Meeting–a premier biomedical research conference–runs December 6-10 in Philadelphia, Pennsylvania. Its Keynote Talks will span the origin of life to the cosmos. Remember that the companies highlighted here in Tech News will be exhibiting, but these specific products may not be at the shows.
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Replaces the 7200A, with new capabilities that will significantly boost laboratory performance
Features improved hardware performance, newly upgraded software features, and exact mass databases
Provides improved mass accuracy specification of less than 3 ppm and an extended mass range, optimizing its capabilities for the most challenging problems
Includes chemical ionization source and backflush capabilities as standard
Measure particle size from 0.3 nm – 10 μm and zeta potential in aqueous and organic solvents
New capabilities include expanded size and concentration dynamic ranges
Touch panel display allows for easy viewing of count rate
Zeta potential is now measured using a proprietary DSP-based phase analysis light scattering module which is more sensitive, stable, and works at higher concentrations
Expands on the capabilities of the FluoroMax series with the option of a second detector and two position grating turret, providing an extended range out to 1650 nm, and TCSPC performance down to 25 ps
Enables faster measurement of weaker and smaller samples
Offers a powerful separation method for the most complex sample matrices
Combines two independent separation modes orthogonally in combination with a dual-loop/ dual-valve alternate switching system to increase separation efficiency
Enables the separation of peaks that are difficult to separate using conventional LC
Achieves the highest possible theoretical plates for LC separation
Now includes a 5 μm particle size for smallscale purifications
Enables higher efficiencies and higher loading capability for small-scale peptide purification in 10 mm ID semi-prep columns and 21.2 mm ID Axia™-packed prep columns
Fully scalable over four particle sizes–1.7 μm, 2.6 μm, 3.6 μm, and 5 μm–enabling easy method transfer
Designed specifically for labs needing to maintain their current GC or single quadrupole GC-MS workflows while adding triple quadrupole capabilities with minimal disruption
Allows users to run their current methods and then easily move over to MS/MS analysis when the time is right for them, on a familiar system using the Chromeleon chromatography data system
Incorporates a Brookfield® DV2T digital viscometer and thermoelectrically controlled sample chamber
Automates the entire conditioning and testing process, including preheating, room temperature stabilization, cooling of the sample to test temperature, and testing the final viscosity of the conditioned sample
Lessens the hands-on time needed to prepare and run a D2983 viscosity test and improves test precision
Combines the CVC3000 vacuum controller and a solenoid valve, to provide advanced two-point control for any standalone diaphragm vacuum pump from VACUUBRAND® or competitive units
New “detect” feature allows the CVC3000 to automatically find the first boiling point with a rotary evaporator
Allows the preprogramming of up to ten multi-step programs, bi-directional communication via RS232 serial port, and more
Include a DIN package for liquids with medium viscosities; a yield point determination package for difficult to measure samples, and an educational package for beginners
DIN package features a liquid temperature control module and coaxial cylinder geometry accessory
Yield point determination package includes a universal container holder and vane rotor
Educational package includes a Peltier temperature control module, coaxial cylinders and parallel plates geometry accessories, and RheoWin™ software
Offers advanced temperature control from 1 to 100°C for microfluidic chips, microscope slides and other third party devices
Chemically resistant, robust, reliable, and only 11cm (4 ¼ inches) wide
Enables cooling, heating and thermocycling with an accuracy of 0.5°C, stability and target temperature resolution of 0.1°C, and rapid ramp rates up to 1°C/s
Provides noise reduction performance of - 15 db(A) (75% reduction in noise perception)
Can house either one or two vacuum pumps
Allows easy access to the rear of the instruments
Noise reduction cabinet integrates an audible & visual (red LED) overheating temperature alarm (on battery backup) for an increased vacuum pump lifetime
Full range of products offers heat, stir, and a heat/ stir combination model, making them suited for the science and education or research markets
The 7”x7” ceramic coated hot plate has a maximum temperature surface rating of 380°C, with stirring speeds that can be precisely controlled between 100- 1500rpm with a maximum capacity of 5 liters
Enable chemists to visibly confirm that their reaction system is being flushed with an inert gas such as nitrogen
Provide a one-way valve through which nitrogen, evolved gases or solvent vapors from the inlet will bubble through the fluid before being vented to the atmosphere
Offers more convenience through the new graphic display and comfort functions
The animated, self-explanatory and wordless symbol display facilitates a rapid and easy selection of all functions
Streamlined design reduces air flow disturbances in laminar flow hoods
Safety Control System SCS demonstrates state-of-the-art safety technology which constantly analyzes potential hazards and, if necessary, initiates safety measures
Allows researchers to set up their cell culture seeding, feeding, expansion, plating and maintenance protocols to automatically produce consistent quality cells for extended periods of time
Includes a unique SelFeeder liquid handling unit that allows scheduled feeds and media changes and also has a gentle liquid addition and removal action
Mimics the natural RNA interference process by using recombinant human dicer enzyme, a double-stranded RNA-specific endonuclease, to cleave in vitro transcribed dsRNA templates into a pool of 22 bp siRNAs
Allows easy and cost-effective generation of a large number of small interfering RNAs (siRNAs) from full-length target genes
Contains everything required for preparing double stranded RNA, RNA cleavage, siRNA cleanup and transfection
Designed for the study of double strand DNA breaks through the detection of gamma H2AX
Developed for anti-cancer drug screening, basic research and upcoming clinical trials providing one of many needed tools to support hypothesis-driven drug design strategies
Documents differences in gamma H2AX levels in peripheral blood mononuclear cells, cultured cells, and tissue biopsies
Main new features include simultaneous multielement analysis of any number of analytical wavelengths within the spectrum window
Integration ranges for each line can be selected freely, for increased sensitivity
A new background correction method and an improved spectral correction of interferences allow simple and automatic correction of complex structured spectral background and overlapping matrix lines
Since each database can have its own independent design, this arrangement means that widely varying requirements can be accommodated on the same system
Matrix Gemini is an ODBC (Open Database Connectivity) compliant system which will operate with a number and mixture of commercial databases to suit either corporate standards or user preferences
Makes it easy to integrate any of the Viscotek SEC detectors with Waters Empower® -driven SEC systems, for powerful, efficient protein characterization
Features the ability to directly interrogate analytical sequences within the Waters Empower® software
Eliminates the need to input sequences in duplicate, making an integrated system easier to use, quicker to set-up and less prone to errors
Simplifies next-generation sequencing (NGS) sample preparation and PCR set-up
Offering user-friendly, walkaway automation of library preparation at the touch of a button, it eliminates the need for extensive manual processing
Designed to offer robust and reliable automation–including library preparation, quantification, qPCR set-up, normalization, pooling and capture–even for inexperienced users
Combines impedance and multi electrode array (MEA) technology with a pacing function
The first platform to allow simultaneous cardiomyocyte contractility and field potential measurement
Designed to be placed in a standard tissue culture incubator with physiological temperature, CO2 level and humidity, allowing better controlled assays with both shortterm and long-term measurements in real-time
Can multiplex up to six channels and deliver higher optical resolution for crisp and clear data capture in each channel
Features rapid cycle time and ultra-fast brilliant qPCR reagents that enable rapid, comprehensive workflow
An onboard diagnostic system provides two modes: a quick pre-test, which covers over 60 performance attributes, and a comprehensive 30-minute test, which covers more than 120 attributes
Complete workflow includes a SureGuide Cas9 nuclease kit, SureGuide gRNA synthesis kit and SureGuide gRNA control kit, all designed to work together for any lab interested in quickly enabling next-generation genome engineering
Series of tools will enable in-vitro cloning of large genes or complex DNA mixtures without the limitations imposed by common restriction enzymes or PCR fidelity
New system standardizes Western Blotting for more consistent analysis
Booth 525
Last month, GE Healthcare Life Sciences launched its new Amersham WB system, a fully integrated system for quantitative SDS-PAGE and Western blotting of proteins using fluorescence detection. The system aims to reduce the variability seen with conventional Western blotting by standardizing and monitoring each stage of the Western blotting process, including electrophoresis, transfer, probing, and scanning. That means more consistent, quantitative protein analysis.
“The value of the insights provided by Western blotting has kept it relevant for more than 30 years, but its shortcomings are well-recognized,” said Eric Roman, general manager of research and applied markets at GE Healthcare Life Sciences. “Building on GE’s heritage and expertise in protein analysis, what we have developed is a system that is set to shift how scientists see and use Western blotting from now on, with a clear focus on reliability and quantification of results, regardless of user.”
Western blotting requires a complex combination of analytical knowledge, extensive manual handling, dexterity and strict adherence to protocols in order to achieve reliable results. According to GE, failure rates, however, can be as high as 25 percent and data variations between different users can be as high as 35-40 percent. The Amersham WB’s standardized Western blotting workflow typically achieves a variability of less than 10 percent between users.
“The publication landscape has changed dramatically over the past year, and the need for quantified blots and data is of significant importance for peer-reviewed journals,” said Martin Teichert, a research scientist at DKFZ (German Cancer Research Center) in Heidelberg, Germany. “I think that the Amersham WB system fits perfectly into this niche, and solves this problem of having quantifiable data that can be relied upon. It has arrived at just the right time.”
Rapidly removes a wide range of solvents, from volatile organic solvents through to DMF, including water
Especially suited for concentrating precious samples in applications including oligonucleotide synthesis, RNA/DNA preparation, peptide preparation, sequencing, molecular biology and ADME / toxicology research
Capable of removing water and organic solvents from biological samples in a range of formats including tubes, microplates, and vials
Draws gene expression profiles from just 10ng of RNA sets
Compatible with formalin-fixed, paraffin-embedded (FFPE) samples
Provides a faster and more cost-effective workflow without the sample manipulation required for microarrays or analytical complexity normally associated with whole transcriptome RNA-sequencing
Available for primary and stem cell isolation, regenerative medicine, biopharmaceutical and cell bioprocessing applications
Animal origin free (AOF)
New, specialized combinations of AOF Clostridium histolyticum collagenase and AOF Bacillus polymyxa neutral protease (Dispase®) offer a minimum of 250 CLS units and 1,000 or 2,000 caseinase units per mg dry weight, respectively
Integrates FEI’s latest-generation SEM with VolumeScope, an in-chamber microtome and proprietary analytical software to provide fully-automated, large-volume reconstructions with dramatically improved z-axis resolution
Ensures fast, easy analysis, while the combination of ThruSight™ and MAPS™ software delivers unprecedented resolution over large sample volumes
Switching between volume imaging and normal SEM operation is fast and easy
Exactly meet the demands of the user’s application or project
Company also offers a totally bespoke solution for pressure reactors ranging from just a few millilitres to 50 litres capacity and different construction materials for corrosive and caustic materials
Custom versions of DrySyn range of heating and cooling blocks, glassware, and PTFE components and apparatus also available
For the cultivation of non-adherent cell lines, spheroids, and stem cells in a 96- well plate format
Treated with a proprietary hydrogel that creates a hydrophobic interface between the surface of the plastic and cellular material to inhibit cell and protein attachment
Microplate surface successfully suppresses the adhesion of a wide variety of adherent cell lines, and more
Replaces the 7200A, with new capabilities that will significantly boost laboratory performance
Features improved hardware performance, newly upgraded software features, and exact mass databases
Provides improved mass accuracy specification of less than 3 ppm and an extended mass range, optimizing its capabilities for the most challenging problems
Includes chemical ionization source and backflush capabilities as standard
Measure particle size from 0.3 nm – 10 μm and zeta potential in aqueous and organic solvents
New capabilities include expanded size and concentration dynamic ranges
Touch panel display allows for easy viewing of count rate
Zeta potential is now measured using a proprietary DSP-based phase analysis light scattering module which is more sensitive, stable, and works at higher concentrations
Expands on the capabilities of the FluoroMax series with the option of a second detector and two position grating turret, providing an extended range out to 1650 nm, and TCSPC performance down to 25 ps
Enables faster measurement of weaker and smaller samples
Offers a powerful separation method for the most complex sample matrices
Combines two independent separation modes orthogonally in combination with a dual-loop/ dual-valve alternate switching system to increase separation efficiency
Enables the separation of peaks that are difficult to separate using conventional LC
Achieves the highest possible theoretical plates for LC separation
Now includes a 5 μm particle size for smallscale purifications
Enables higher efficiencies and higher loading capability for small-scale peptide purification in 10 mm ID semi-prep columns and 21.2 mm ID Axia™-packed prep columns
Fully scalable over four particle sizes–1.7 μm, 2.6 μm, 3.6 μm, and 5 μm–enabling easy method transfer
Designed specifically for labs needing to maintain their current GC or single quadrupole GC-MS workflows while adding triple quadrupole capabilities with minimal disruption
Allows users to run their current methods and then easily move over to MS/MS analysis when the time is right for them, on a familiar system using the Chromeleon chromatography data system
Incorporates a Brookfield® DV2T digital viscometer and thermoelectrically controlled sample chamber
Automates the entire conditioning and testing process, including preheating, room temperature stabilization, cooling of the sample to test temperature, and testing the final viscosity of the conditioned sample
Lessens the hands-on time needed to prepare and run a D2983 viscosity test and improves test precision
Combines the CVC3000 vacuum controller and a solenoid valve, to provide advanced two-point control for any standalone diaphragm vacuum pump from VACUUBRAND® or competitive units
New “detect” feature allows the CVC3000 to automatically find the first boiling point with a rotary evaporator
Allows the preprogramming of up to ten multi-step programs, bi-directional communication via RS232 serial port, and more
Include a DIN package for liquids with medium viscosities; a yield point determination package for difficult to measure samples, and an educational package for beginners
DIN package features a liquid temperature control module and coaxial cylinder geometry accessory
Yield point determination package includes a universal container holder and vane rotor
Educational package includes a Peltier temperature control module, coaxial cylinders and parallel plates geometry accessories, and RheoWin™ software
Offers advanced temperature control from 1 to 100°C for microfluidic chips, microscope slides and other third party devices
Chemically resistant, robust, reliable, and only 11cm (4 ¼ inches) wide
Enables cooling, heating and thermocycling with an accuracy of 0.5°C, stability and target temperature resolution of 0.1°C, and rapid ramp rates up to 1°C/s
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