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OGT Develops Transformative Constitutional NGS Panel

CytoSure NGS—Combining the benefits of microarrays and NGS in a single assay

by Oxford Gene Technology
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Oxford, UK — Oxford Gene Technology (OGT), A Sysmex Group Company, has developed a breakthrough targeted NGS panel for constitutional cytogenetics research. The new CytoSure™ NGS panel—launching early in 2020—will combine the strengths of microarrays and NGS to deliver a comprehensive all-in-one assay. The new panel, in conjunction with OGT’s popular Interpret analysis software facilitates the accurate and confident detection of loss of heterozygosity (LOH), mosaicism, and copy number variants (CNVs), in addition to those more traditionally assayed by NGS, single nucleotide variants (SNVs) and insertions/deletions (indels). 

Oxford Gene Technology CytoSure™ NGS panelOxford Gene Technology's CytoSure™ NGS panel.Credit: Oxford Gene TechnologyFeaturing the most up-to-date content for intellectual disability (ID) and developmental delay (DD), the new targeted NGS panel and Interpret software enable users to detect even small (single exon) CNVs accurately—something that is has been challenging with NGS and hence a major step forward for the technology. 

Emma Shipstone, EVP, marketing at OGT commented, “We have developed our CytoSure NGS panel to meet the increasing desire of labs to transition from microarrays to NGS and obtain as much information as possible from a single assay. NGS technologies have traditionally struggled with CNV detection, but thanks to OGT’s panel design expertise and advanced software algorithms, we have overcome these challenges, delivering exceptional CNV data that exhibits excellent concordance with arrays. The results are very easy to interpret, with our highly intuitive software allowing a seamless transition to NGS for ID/DD analysis, in what has historically been the domain of the array. Ahead of launch early next year, our early access collaborators are telling us that the data quality speaks for itself and more than meets their requirements.” 

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Dr. John Anson, CEO of OGT also added, “Moving with and anticipating market needs, we’re strengthening our CytoSure brand in constitutional cytogenetics with the development of our first CytoSure NGS panel. OGT, as a part of Sysmex, is committed to developing our assay portfolio, delivering the highest quality solutions to meet the real-world challenges faced by cytogeneticists. CytoSure NGS represents a real leap forward in NGS technology, demonstrating OGT’s capability—as experts in hybridization—to lead the global market in this field.” 

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CytoSure™ For Research Use Only; Not for Use in Diagnostic procedures