PerkinElmer: Analysis of an Antibiotic Ophthalmic Solution by UHPLC/SQ MS
An expired ophthalmic solution of trimethoprim and polymyxin B sulphates was analyzed for degradants using UHPLC/SQ MS.
An expired ophthalmic solution of trimethoprim and polymyxin B sulphates was analyzed for degradants using UHPLC/SQ MS. The ophthalmic solution is used to treat bacterial eye infections and is active against a variety of gram negative and gram positive bacteria. An assay to detect degradants formed during storage beyond the expiration date of this diluted antibacterial ophthalmic solution is described.
