Resource Guide: HPLC-Charged Aerosol Detection

The analysis of excipients and impurities comes with several challenges.

1. Separation: Structures of the impurities are mainly hydrophilic and ionic, requiring special separation techniques like mixed-mode chromatography.
2. Detection: Analytes lacking a chromophore are not detected by optical detectors, which are the main devices used in pharmaceutical monographs.
3. Quantitation: Reference standards are often not available for excipients and their related substances.

Download this free resource guide for applications and helpful information as to how HPLC combined with a charged aerosol detector can meet the needs of scientists working with excipients and active pharmaceutical ingredients.