2016 Automated Liquid Handling Survey Results
Automated liquid handling (ALH) systems span the range from semi-automated multichannel pipettors to room-sized systems. The industry is trending toward versatile, modular ALH systems—seemingly for every budget. Likewise, instrumentation, software, and methods have followed the trend toward greater user accessibility.
Top 7 Questions You Should Ask When Buying an Automated Liquid Handler
- What kind(s) of dispensing technology is used? Peristaltic pump dispensing offers low prime volumes and backflushing; microprocessor- controlled syringes have fast output and high precision. Hybrid detection systems combine both technologies in one and can even add washing functions.
- Is plate handling automatable? Manual plate handling can slow productivity. Automating the process with a compatible microplate stacker increases throughput with walk-away operation.
- Can it accommodate magnetic or plastic bead-based assays? If using bead-based assays, it should be equipped with appropriate magnets or vacuum filtration for critical wash steps.
- What is the volume range, and how many different sample vessel types may be used?
- Ask about the software—is it integrated and user-friendly? Does it allow for pre-programmed and custom protocols?
- What is the flow rate spectrum? A wide flow rate spectrum allows use with sensitive cell-based assays to viscous liquids.
- What assay validation data is available for this specific liquid handler? This provides proof that the instrument performs as indicated.
Types of automated liquid handling systems used by survey respondents:
Individual benchtop workstations | 59% |
Stand-Alone | 52% |
Self-contained multi instrument systems | 27% |
Other | 2% |
Applications for automated liquid handling systems as reported by survey respondents:
Serial dilution | 66% |
PCR setup | 45% |
Plate replication | 43% |
Plate reformatting | 32% |
High-throughput screening | 23% |
Cell culture | 14% |
Array printing | 9% |
Whole genome amplication | 7% |
High-density array printing | 5% |
Other | 18% |
Nearly 56% of respondents are engaged in purchasing a new automated liquid handling system. The reasons for these purchases are as follows:
Addition to existing systems, increase capacity | 55% | ||
Replacement of an aging system | 28% | ||
First time purchase | 10% | ||
Setting up a new lab | 7% |
Top 10 features/factors respondents look for when purchasing an automated liquid handler:
Accuracy and precision for a wide range of compatible fluids | 83% |
Safe sample handling - No cross-contamination | 83% |
Maximum operator safety | 58% |
Maintenance/service/availability of accessories and replacement parts | 57% |
Rapid throughput | 57% |
Price | 50% |
Sample tracking – automated recording and sample data documentation with a choice of bar code reader options | 46% |
Ability to expand on instrument as requirements change | 42% |
Pipetting flexibility - Pipette with 384, 96, 24, 16, 12, or 8 tips | 40% |
Size – small footprint | 30% |
For more information on liquid handlers, including useful articles and a list of manufacturers, visit www.labmanager.com/liquid-handling